Sustained Deficits Research Articles

CNSC-05. MAPPING LANGUAGE PROCESSING IN SURGICAL GLIOMA PATIENTS

Abstract Previous work from our group has shown that the resection of white matter tracts localized by transcranial magnetic stimulation (TMS) predicts postoperative neurological deficits. Here we use advanced preoperative brain mapping along with formal language evaluations to localize the neuroanatomical underpinnings of language processing in surgical glioma patients. In patients who had TMS tracts resected, the resected portions (“tract-cavity segmentations”) were classified according to the functional outcome (“true positives”-corresponding deficit; “false positives”-no deficit) and normalized to MNI space. For patients who sustained long-term deficits, TMS tracts were segmented according to spatial overlap with normative tracts to create ROIs. Each normalized resection cavity (n=79) was analyzed for overlap with each ROI associated with postoperative deficits (n=8). The percentage of patients who had positive ROI resections that included TMS tracts versus patients who had positive ROI resections irrespective of TMS tracts were analyzed according to the percent who sustained deficits in each group. ROIs from all patients were summed to create a probabilistic atlas of functional white matter. “True positive” tract-cavity segmentations localized into dual anterior/posterior “hubs” and demonstrated significantly higher spatial association with normative tracts across three different measures (p<.05). 92% of patients who underwent ROI resections that included TMS tracts sustained long-term deficits while 34% of patients who underwent ROI resections irrespective of individualized mapping sustained deficits (p<.05). The probabilistic atlas of functional white matter demonstrated significantly higher voxel intensities within the white matter deep to the temporoparietal junction defined by the same posterior “hub” ROI from Figure 1 (p<.001). This study demonstrates that essential language processing localizes to ROIs within normative white matter tracts that require individualized mapping for surgical preservation. The white matter deep to the temporoparietal junction serves as a crucial hub for language-processing circuitry in glioma patients.

Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke.

Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke can also independently reduce flow velocity. However, the chronology and topological changes in collateral circulation in T2DM is not yet defined. Here, we describe the spatial and temporal blood flow dynamics and vessel remodeling in pial arteries and veins and leukocyte-endothelial adhesion following middle cerebral artery (MCA) stroke using two-photon microscopy in awake control and T2DM mice. Relative to control mice prior to stroke, T2DM mice already exhibited smaller pial vessels with reduced flow velocity. Following stroke, T2DM mice displayed persistently reduced blood flow in pial arteries and veins, resulting in a poor recovery of downstream penetrating arterial flow and a sustained deficit in microvascular flow. There was also persistent increase of leukocyte adhesion to the endothelium of veins, coincided with elevated neutrophils infiltration into brain parenchyma in T2DM mice compared to control mice after stroke. Our data suggest that T2DM-induced increase in chronic inflammation may contribute to the remodeling of leptomeningeal collateral circulation and the observed hemodynamics deficiency that potentiates poor stroke outcome.

The Effect of Sustained Deficit Irrigation and Different Irrigation Methods on Yield and Evapotranspiration of Second-Crop Soybeans in the Mediterranean Basin

The Effect of Sustained Deficit Irrigation and Different Irrigation Methods on Yield and Evapotranspiration of Second-Crop Soybeans in the Mediterranean Basin

Potential of sustained deficit irrigation to enhance biological and nutritional quality of pomegranate fruit during storage

BackgroundWhile water availability is important for quality at harvest, it also continues to influence the quality of pomegranates during storage. Reducing the amount of irrigation, in addition to water saving has different effects on bioactive compounds of pomegranate during storage time. This study was conducted to determine the influence of irrigation level on fruit quality changes during storage period of two commercial Iranian pomegranate cultivars (‘Shishecap’ and ‘Malas-Yazdi’). Sustained deficit irrigation (SDI) was applied to plants that received 75% (moderate stress) or 50% (severe stress) of their normal water requirement. A control group received 100% of their water requirement.ResultsAt harvest time and during storage period, fruit weight loss and some biochemical traits such as fruit total soluble solids (TSS), titratable acidity (TA), pH, total phenolic compounds (TPC), total anthocyanins content (TAC), antioxidant activity and vitamin C were measured in pomegranate fruits. Also, the quantity of the produced product was also measured at the time of harvesting. Results indicated that control fruits exhibited more weight loss than those produced under water deficit during the storage period in both years. According to results, fruit TSS, TAC, and antioxidant activity significantly increased during storage period but fruit TA and vitamin C significantly decreased throughout storage period. Also, reduction in irrigation level resulted in a decline in the yield.ConclusionsThis study revealed a crucial link between irrigation level and the quality of pomegranate fruits, despite a reduction in the yield. This included affecting weight loss and the content of bioactive compounds, both at harvest and during storage.

TiO2 NPs as a Promising Strategy for Crop Conservation Resulting from Deficit Irrigation in Fragaria × ananassa Cv. Camarosa

ABSTRACT Nanoparticle-based methods can compensate for yield and quality loss of crops affected by drought. The current study, performed in a factorial experiment based on a completely randomized design, addressed to evaluate the effect of titanium dioxide nanoparticles (TiO2 NPs) at 0, 10, 20, and 30 mg L−1 under three irrigation regimes (full irrigation, partial root drying (PRD), and sustained deficit irrigation (SDI)) on Fragaria × ananassa cv. Camarosa. Results revealed that the PRD stress had more adverse effects on F. ananassa cv. Camarosa than SDI stress. Assessment of the behavior of TiO2 NPs in this study elucidated that mean productivity, yield stability index, and fruit number in plants grown under full irrigation increased when treated with 10 mg L−1 TiO2 NPs. Under the deficit irrigation, including PRD and SDI, all levels of TiO2 NPs mitigated mean productivity and yield stability index by ameliorating the fruit number and water use efficiency (WUE) and decreasing transpiration. Flowering and fruit set times were reduced by TiO2 NPs and deficit irrigation while their periods were enhanced by ones. It seems that when the strawberry was exposed to TiO2 NPs exhibited approximately drought tolerance. These nanoparticles ameliorated photosynthesis and mineral uptake and allocated dry matter to the root. These alterations can contribute to crop production in deficit irrigation strategies.

Contribución de la ganadería mexicana a la seguridad alimentaria nacional, a tres sexenios del TLCAN

In recent decades Food Security (FS) has become a topic of global interest, with food shortages and deficient diets at home being a serious problem faced by humanity. The objective was to analyze the role of livestock in the FSof Mexico, period 1994-2012, toevaluate and contrast, livestock production and the availability of food for the national population. A descriptive and comparative multidimensional analysis was carried out with statistics from official sources, finding a significant increase in the volume of livestock production, a significant rise in prices and a sustained deficit trade balance. Therefore, livestock shows a significant contribution to the Mexican food security, supplying with national production the nutritional requirements established by the National Council for the Evaluation of Social Development Policy (CONEVAL) for a balanced and healthy diet.

The Effects of the Twin-Deficit Hypothesis: A Study Case for Romania

The purpose of the paper is to explore the broader economic implications of the twin-deficit hypothesis, specifically the crowding-out effect and the deterioration of the domestic manufacturing sector. The hypothesis posits that government borrowing can inhibit private investments and growth. Such a case has been observed empirically in other countries, where high government borrowing suppressed private sector borrowing and investments. Additionally, the paper investigates how sustained deficits can erode the manufacturing sector by increasing reliance on imports, leading to the contraction of local industries and affecting employment and domestic expertise.

Could regulated and sustained deficit irrigation be applied in temperate climates? A case study of soybean production under field conditions

A field experiment was conducted to study the effects of full (F), regulated (RDI), and sustained deficit irrigation (SDI) on yield (Y), evapotranspiration (ET), and water use efficiency (WUE) of drip irrigated soybean. The yield response factor (Ky) was calculated to express the effect of water stress on soybean yield. The water balancing approach was used to schedule irrigation. Daily water used for plants' evapotranspiration was calculated by multiplying reference evapotranspiration with crop coefficients. Irrigation started when readily available water in the soil layer of 0.4 m was completely depleted by plants. There were statistical differences in yield between F (4.60 t ha−1) and SDI (3.71 t ha−1) treatments, but not between F and RDI (4.44 t ha−1). The evapotranspiration rate varied between 439 and 535 mm under irrigation and between 193 and 306 mm under rainfed conditions. The WUE values were consistent with the yield of the treatments. The statistical difference in soybean yield between F and SDI strategies suggests that the SDI cannot be used in the region's soybean farming. As no water savings were recorded for the same level of soybean yield between F and RDI, it indicates that RDI is not beneficial under the temperate climate of the Vojvodina region. The yield response factors of 0.69 and 0.71 in 2022 and 2023, respectively, show that soybean is tolerant to water stress and could be grown in rainfed conditions in Vojvodina's temperate climate. However, to achieve high and consistent yields, irrigation is advised.

Disentangling the Physiological Responses of Sweet Orange Citrus Trees to Optimize the Design of Deficit Irrigation Strategies

Climate change scenarios and water restrictions are key challenges for Mediterranean citriculture, requiring sustainable deficit irrigation (DI) strategies to ensure sustainable yields. Further research on the physiological pathways that regulate crop responses to water stress is necessary. This work describes the physiological limitations induced under drought conditions in young Navelina orange trees, including the crop’s capability to recuperate its physiological status upon rewatering and after water withholding. A trial was conducted in two-year-old trees subjected to three irrigation treatments: a full irrigation treatment (FI) and two different DI strategies. The results show significant decreases in gas exchange rates for stem water potential (ΨStem) values below −1.5 MPa, evidencing diffusive limitations from drought stress. Additionally, there was evidence of increased osmolyte synthesis, a preventative response to oxidative damage. Significantly increased levels of proline (Pro) and malondialdehyde (MDA) were observed with higher levels of water stress (ΨStem < −1.8 MPa), which leads us to assume that this threshold signals the presence of oxidative damage with no capacity for subsequent recovery, probably affecting the final yield.

Nitrogen requirements of canola (Brassica napus L.) at sustained deficit irrigation levels in central Free State, South Africa

In South Africa canola (Brassica napus L.) is cultivated in rotation with wheat under winter rainfall in the Western Cape province. Expansion of the crop to the other eight provinces is propagated to reduce a shortage of locally produced plant oils. At the same time, canola may serve as a rotational crop for wheat in these summer rainfall provinces. In central Free State, agronomic information for canola production is lacking. An experiment with a line source sprinkler irrigation system was therefore conducted to establish the influence of water application levels (175, 233, 295, 351 and 420 mm) in combination with nitrogen (N) application rates (0, 70, 140, 210 and 280 kg ha−1) on the branches, pods and seeds per canola plant. The biomass and seed yields of canola were also measured, allowing calculation of harvest indices. All six variables were strongly influenced by the interaction of water and N applications. An optimal seed yield of 2.907 kg ha−1 was estimated with a 351 mm water application and a 280 kg ha−1 N application. This resulted in a water use efficiency of 8.28 kg seed ha−1 mm−1 water and a nitrogen use efficiency of 10.38 kg seed kg−1 N.

Water Use Efficiency in a Deficit-Irrigated Orange Orchard

Citrus is a subtropical fruit tree with high water requirements. This study aimed to determine the effects of water deficit on an orange orchard subjected to different water-saving strategies. The study was realised in an orange orchard in a semiarid area by adopting four different water management techniques: 100% crop evapotranspiration (control); SSDI—subsurface sustained deficit irrigation; RDI—regulated deficit irrigation; PRD—partial rootzone drying treatment during five growing seasons. The experimental design foresaw a randomised block design with six replicates per treatment (24 index plants). The results of the study showed that the water-saving strategies reduced irrigation water consumption by 25% (SSDI), 33% (RDI), and 49% (PRD) compared to the fully irrigated treatment without yield reduction, thus increasing water use efficiency. Mineral nutrition of the trees was slightly affected by irrigation treatments; element concentration in leaves was generally in the optimal range; only potassium showed values below the recommended leaf concentrations. Regarding fruit quality parameters, the vitamin C concentration in RDI showed significant differences with a value of 62.7 mg 100 mL−1 compared to 58.5 mg 100 mL−1 in the control. Plants subjected to SSDI and PRD strategies showed increased levels of pulp colour index with significant values of 10 and 9.90, respectively, compared to the control (8.44). By implementing targeted water management, citrus growers could save water and increase the ascorbic acid and sugar concentration in the fruits; anthocyanins also increased but not significantly. These findings open new market opportunities for citrus growers in marginal areas, where they cannot rely solely on producing citrus fruits to remain competitive.

Single Nuclear Analyses Reveal Compromised Integrity of Neuromuscular Junction Myonuclei Following Joint Injury

The neuromuscular junction is an essential structure that links electrical signals from the nervous system to contraction of skeletal muscle. The post synaptic region of a muscle cell is maintained by a subset of specialized myonuclei responsible for clustering of post synaptic structural proteins and acetylcholine receptors. Disruptions in the transcriptional program of these myonuclei may result in ineffective myofiber recruitment, slowed force generation, and muscle weakness. We have shown that traumatic joint injury results in protracted deficits in muscle strength and power, but the peripheral mechanistic underpinnings remain unclear. Phenotypically, muscle pathology occurring after traumatic joint injury resembles that of neuromuscular destabilization, yet molecularly, this remains uninvestigated. Therefore, we hypothesize that disruption of neuromuscular regulatory gene programs and destabilization of the neuromuscular junction following joint injury will result in rapid muscle functional deficits. Human muscle biopsies were obtained from the vastus lateralis of anterior cruciate ligament (ACL) injured and healthy limbs of 26 participants. Injured biopsies were taken before and 7 days following reconstruction surgery. Bulk tissue RNA-seq analysis was performed on all participants and single-nucleus RNAseq (snRNAseq) was performed on a subset of participants. Briefly, for snRNAseq, muscle was dounce homogenized, filtered, and nuclei isolated via fluorescent activated cell sorting. Following sequencing, CellRanger output files containing count matrices were filtered, and analyzed using Partek Flow and Seurat. Biopsy sections were processed for histochemistry to analyze fiber size and motor end plate innervation. All participants underwent strength testing on a biodex to assess isometric quadriceps torque and rate of torque development. RNA sequencing displayed >3 fold upregulation of CHRNA1 (P< 0.001) after injury alone and >18 fold upregulation 7 days following reconstruction surgery (P< 0.001). This was accompanied by a host of other neuromuscular regulatory genes including HDAC4 (P< 0.001), GDNF (P< 0.001), and RUNX1 (P< 0.001). Single nucleus sequencing revealed a complete disappearance of neuromuscular junction regulatory myonuclei following reconstruction surgery coupled with delocalization of acetylcholine receptor expression. These findings were confirmed with fluorescent in situ hybridization of CHRNA1 RNA on biopsy sections. Functionally, CHRNA1 RNA expression strongly correlates with deficits in rate of torque development following injury (R^2 = 0.85, P< 0.001). Our results display rapid remodeling of the postsynaptic neuromuscular junction following joint injury that underscores sustained deficits in strength and power. Interventions targeting the preservation of peripheral innervation may be warranted to enhance outcomes following joint injury. R01AR072061. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

A critical size volumetric muscle loss model in mouse masseter with impaired mastication on nutrition.

Orofacial muscle defect due to congenital anomalies, tumour ablation or traumatic accident that exceeds endogenous regeneration capacity may lead to sustained deficits in masticatory function and nutrition intake. Functional recovery has always been the goal of muscle tissue repair, but currently, there is no suitable model for quantitative analyses of either functional consequences or treatment efficacy of orofacial muscle defect. This study proposed a critical size volumetric muscle loss (VML) model in mouse masseter with impaired mastication on nutrition. Full-thickness VML defects in diameter of 1.0, 1.5, 2.0 and 3.0 mm were generated in the centre of the mouse masseter using a biopsy punch to determine the critical size for functional impairment. In the VML region, myogenesis was dampened but fibrogenesis was activated, as long with a reduction in the density of the neuromuscular junction and an increase in vascular density. Accordingly, persistent fibrosis was observed in the centre region of VML in all diameters. The 2.0 mm diameter was the critical threshold to masticatory function impairment after VML in the masseter. VML of 3.0 mm diameter led to a significant impact on nutrition intake and body weight gain. Autologous muscle graft effectively relieved the fibrosis and functional deficit after VML injury in the masseter. This model serves as a reliable tool in studying functional recovery strategies for orofacial muscle defects.

Optimizing water use and crop yield with deficit irrigation techniques: A comprehensive overview and case study from Morocco

Water scarcity is a global challenge that threatens agricultural productivity and food security. Irrigation agriculture consumes most of the world’s freshwater resources and often suffers from low water use efficiency. To address water shortages, deficit irrigation techniques have been developed to minimize water inputs while sustaining or enhancing crop yields and quality. Deficit irrigation consists of allocating a minimum amount of water to the crop. It can be applied either for the entire growing season (sustained deficit irrigation) or for specific crop stages (regulated deficit irrigation). Another technique is partial root zone drying, which involves alternately irrigating different parts of the root system. This causes partial water stress and increases the water uptake efficiency. These techniques aim to maximize net water use efficiency by exploiting the physiological responses of crops to water stress. This paper provides a theoretical background on deficit irrigation, a review of recent studies on its effects on different crops and environments, and a case study in Morocco where sustained deficit irrigation was applied to peach trees in a semiarid region. The findings showed that sustained deficit irrigation reduced water use by 20% without affecting fruit yield or quality and increased water productivity by 33%. This paper also discusses the challenges and opportunities for implementing deficit irrigation in different contexts and provides some recommendations for future research and development.

Optimizing water productivity for Menara olive cultivar: Exploring the impact of regulated and sustained deficit irrigation strategies in Morocco

The agricultural sector in Morocco faces drought challenges due to limited water resources, necessitating the development of irrigation strategies targeted at increasing water production. In this regard, the olive sector can adopt deficit irrigation strategies, to achieve sustainable management practices that improve water productivity and save water used for irrigation. In pursuit of this aim, an experiment was carried out in an olive orchard over two consecutive years (2021 and 2022), comparing water productivity (WP) of four treatments of regulated deficit irrigation (RDI) and two treatments of sustained deficit irrigation (SDI), with fully irrigated trees. The results indicated that over time the RDI strategy, particularly in the T4 treatment, makes it feasible to conserve a substantial amount of irrigation water, approximately 40% during the phase when pit hardening occurs, and 20% during sensitive periods, all without compromising fruit yield. However, the SDI strategy, with its limited water availability, leads to a decline in the fruit yield of Menara olive trees. Out of these treatments, the SDI strategy led to the most substantial decrease in WP, with reductions ranging from 19% to 33% compared to the control T0.

Diversified cropping systems effect on the water status of mandarin trees under deficit irrigation

The diversified cropping systems has several environmental benefits, but there is no certainty about their effect on the water status of trees, especially in areas with permanent low availability of irrigation water. Therefore, our objective was to evaluate the effect of the establishment of diversified cropping systems in a traditional monoculture (MC) of adult mandarin trees on its water status and yield under sustained deficit irrigation (SDI) and regulated deficit irrigation (RDI). Six treatments were tested during three consecutive seasons: (i) a mandarin monoculture under SDI (MC-SDI), with permanent bare alleys and irrigated at ∼70 % ETc during the entire season (actual amount of irrigation water available in the area); (ii) a diversified mandarin crop (D1-SDI), irrigated as MC-SDI, with a rotation of fava bean and barley/vetch in the alleys; and (iii) a second diversified mandarin crop (D2-SDI), irrigated as MC-SDI, with a seasonal rotation of fava bean, purslane and cowpea. Additionally, three RDI treatments were evaluated, denoted as (iv) MC-RDI, (v) D1-RDI and (vi) D2-RDI, irrigated as MC-SDI, except during the stage II of fruit growth, when it was reduced by 50 % with an irrigation threshold of a solar midday stem water potential of ∼ –1.5 MPa. The mandarin yield was not affected by the effect of diversified cropping systems, but the RDI reduced it on average by 30.1 % with respect to SDI. The alley cropping of fava bean and barley/vetch during winter and spring under sustained deficit irrigation conditions reduced the water stress intensity of mandarin trees by 26.9 % over the entire season, while cultivation of purslane or cowpea during summer increased it by 60–144 %. Both diversifications required a greater amount of water than the monoculture, in these terms an additional reduction in the irrigation of mandarin trees, as in the RDI treatment, allowed to solve this additional water requirement, but promoted an increase in the water stress intensity of the trees, which may affect their productivity in the mid and long-term.

Micro-ultrasound based characterization of cerebrovasculature following focal ischemic stroke and upon short-term rehabilitation

Notwithstanding recanalization treatments in the acute stage of stroke, many survivors suffer long-term impairments. Physical rehabilitation is the only widely available strategy for chronic-stage recovery, but its optimization is hindered by limited understanding of its effects on brain structure and function. Using micro-ultrasound, behavioral testing, and electrophysiology, we investigated the impact of skilled reaching rehabilitation on cerebral hemodynamics, motor function, and neuronal activity in a rat model of focal ischemic stroke. A 50 MHz micro-ultrasound transducer and intracortical electrophysiology were utilized to characterize neurovascular changes three weeks following focal ischemia elicited by endothelin-1 injection into the sensorimotor cortex. Sprague-Dawley rats were rehabilitated through tray reaching, and their fine skilled reaching was assessed via the Montoya staircase. Focal ischemia led to a sustained deficit in forelimb reaching; and increased tortuosity of the penetrating vessels in the perilesional cortex; with no lateralization of spontaneous neuronal activity. Rehabilitation improved skilled reaching; decreased cortical vascularity; was associated with elevated peri- vs. contralesional hypercapnia-induced flow homogenization and increased perilesional spontaneous cortical neuronal activity. Our study demonstrated neurovascular plasticity accompanying rehabilitation-elicited functional recovery in the subacute stage following stroke, and multiple micro-ultrasound-based markers of cerebrovascular structure and function modified in recovery from ischemia and upon rehabilitation.

Deficit irrigation strategies (PRD, SDI) and titanium nanoparticles improve water use efficiency and flower quality in greenhouse-grown cut roses

This study explored the use of deficit irrigation techniques for water management in the hydroponic greenhouse cultivation of cut roses. A factorial experiment was conducted using three irrigation treatments: full irrigation (FI), partial root drying (PRD), and sustained deficit irrigation (SDI), and three doses of titanium dioxide nanoparticle foliar application (0, 15, and 30 ppm) as stress alleviation. Results showed that drought stress increased biochemical parameters such as the plants' proline and total phenol content. Compared to SDI treatment, the PRD treatments have an increase in flower number by 40%. The PRD strategy has positive effects on drought tolerance by increasing osmotic and elastic adjustment. Therefore, higher relative water content and longer root length in PRD treatments were observed. Thus, Biomass water use efficiency significantly increased in PRD treatments compared to others. In the PRD treatment, yield WUE increases by 26% and 61% compared to FI and SDI, respectively. The results showed TiO2-NPs positively affected mitigating and even improving some traits in drought stress conditions. These results suggest the superiority of the PRD strategy, which improves growth characteristics and water use efficiency, leading to increased sustainability, reduced environmental impact of greenhouse toxic wastewater, and total profitability of the greenhouse.

Effect of deficit irrigation and mulching on the agronomic and physiological response of mandarin trees as strategies to cope with water scarcity in a semi-arid climate

In order to increase the crop water productivity (WPc) of the agricultural systems, and to support farmers in minimizing uncertainty of water availability, we conducted a three-years experiment in a commercial adult mandarin orchard to quantify the effect of sustained and severe deficit irrigation in combination with the use of geotextile mulch on the agronomic and physiological response of the crop. For this purpose, five treatments were tested: (i) a control (CTL) irrigated at 100% of the crop evapotranspiration (ETc) during the entire season; ii) sustained deficit irrigation (SDI), irrigated at ∼70% of CTL; (iii) regulated deficit irrigation (RDI), irrigated as SDI, except during the initial period of the second fruit growth stage, when trees were irrigated at 35% of the CTL, maintaining a moderate water stress level of around –1.5 MPa of stem water potential (Ψs), until fruits reached 70% of their final size. In addition, two geotextile mulch treatments were established, using the same irrigation criteria as the SDI and RDI treatments. The available irrigation water supplied about 66% of the crop evapotranspiration, but if it is managed under a SDI regime with the incorporation of mulching it is possible to increase the crop sustainability and reduce the pressure over the water resources. Since SDI did not reduce the yield with respect to the CTL treatment, it increased WPc by 35% and the incorporation of mulch significantly increased the water status of the soil and the crop, thus reducing the intensity of water stress by 18% on average, which was expressed in a higher leaf gas exchange rate and was also a factor that significantly increased crop production variables and WPc.

The macroeconomic implications of deficit financing under present bias

We examine how present bias affects deficit, inflation, and welfare in an economy where the deficit is funded by a seigniorage tax. In a hyperbolic discounting economy, reduced money holdings due to the desire for immediate consumption cause a decline in the sustainable deficit limit. To meet the targeted deficit, the government must raise seigniorage tax collection, especially with present bias. This results in increased inflation rates and higher welfare costs associated with the deficit for hyperbolic discounting individuals.