From Farm to Fork Strategy is at the heart of the European Green Deal – the new growth strategy of the EU and a key to the implementation of Sustainable Development Goals (SDGs). From Farm to Fork Strategy is designed for building a fair, healthy and environmentally-friendly food system with an integrated food safety policy in the Union. Current paper presents some of the strategic accents of the main European documents and initiatives concerning future sustainable agri-food systems in the context of human health and well-being through the ecological, economic and social aspects of sustainability. Special attention is also paid to how the future Common Agricultural Policy (CAP) will contribute to the EU Green Deal, food quality and safety, and sustainable development as a whole. Particular examples are presented showing the support to the agriculture and food sectors amid Coronavirus and rural responses to the COVID-19 crisis as collected by the European Network for Rural Development (ENRD). Good practices from Bulgaria are also analyzed regarding the initiatives of promoting local food through farmers’ markets and online platforms and new challenges and best solutions. Conclusions focus on the general measures and actions for the effective transition to a fair, healthy and environmentally-friendly agri-food system. JEL Codes: I31, Q12, Q18, Q56