This paper expands the Consistent Particle Method (CPM) to simulation of turbidity currents with focus on turbulent water-sediment flow. A mixture model is adopted in solving the sediment transport equation to simulate the sediment mass transfer due to settling convection and turbulent diffusion. To compute the gravity-driven convection term, the proposed CPM-upwind scheme is relatively easy to implement as it avoids the use of a kernel function which has the requirements of symmetry and unity. Two sand settling problems demonstrate the good accuracy of the CPM-upwind scheme. For suspended sediment diffusion caused by turbulence, CPM is able to model anisotropic diffusion without the averaging effect caused by the isotropy requirement if a kernel function is used. The validated CPM methodology is then applied to simulate a sudden flow of water-sediment mixture into ambient water. The results of the mixture front motion and sediment deposit density agree well with published experimental results.