The use of music and mental imagery as therapeutic modalities has received much attention in the last two decades. Mechanisms explaining both techniques can be found within the language of cognitivebehaviorism. For example, music has been effectively demonstrated as a conditioned stimulus for both sympathetic and parasympathetic autonomic activity (Goldstein, 1980; Kibler & Rider, 1983; Slaughter, 1956; Spingte, 1988). Mental imagery, defined as perceptual activation in the absence of actual stimuli (Achterberg & Lawlis, 1980), has been extensively employed in mediating anxiety within systematic desensitization procedures (Wolpe, 1969) and in attenuating pain perception through cognitive strategies (Levine, Gordon, & Fields, 1978; Meichenbaum, 1977; Rider, 1985). The burgeoning discipline of psychoneuroimmunology has had an immense impact on the prolific amount of research on the relationship between stress and immunity (Glaser, Kiecolt-Glaser, Speicher, & Holliday, 1985; Kiecolt-GIaser, Stephens, Lipetz, Speicher, & Glaser, 1985; Locke, Kraus, Lesserman, Hurst, Heisel, & Williams, 1984; Pennebaker & O’Heeron, 1984). Although the utilization of cognitive-behavioral procedures employing imagery and music to affect immunological measures can currently be found in the clinical arena, research on these particular variables is lacking. Techniques related to imagery, such as hypnosis (Black, Humphrey, & Niven, 1963; Hall, 1982-1983)andbiofeedback(Peavey, Lawlis, & Goven, 1985) have been found to positively affect measures of immune functioning. Relaxation procedures, typically employing some imagery and/or music, have also been reported to elicit improved immune functioning in geriatrics (KiecoltGlaser, Glaser, Williger, Stout, Messick, Sheppard, Ricker, Romisher, Briner, Bonnell, & Donnerberg, 1985), improved clinical functioning in medical patients (Luthe, 1969) and cancer patients (Simonton, Mathews-Simonton, & Creighton, 1978), and reduced levels of adrenal corticosteroids in high-stress individuals (Rider, Floyd, & Kirkpatrick, 1985). A central question related to imagery is whether images merely facilitate relaxation, which in turn enhances immunological functioning, or whether specific imagery directed at biological mechanisms has more localized effects on the production, circulation, and activation of immune products. Initial research has been somewhat promising although not altogether conclusive. Features of biological imagery, such as “vividness” and perceived “effectiveness” of one’s immune system, have been found to be highly predictive of survival outcome of cancer patients (Achterberg & Lawlis, 1984). Several studies have been conducted on lymphocytes and neutrophils, the two most prolific subpopulations of white blood cells. White blood cells, or leukocytes, comprise the major portion of the immune system in protecting the body against disease. Neutrophil pooling and adherence has been shown to be affected by 6-7 weeks of cell-specific imaging (Smith, Schneider, Minning, & Whitcher, 1983). In another study, T-cell and natural killer cell counts have been significantly affected following one week of imagery procedures, although no long-term effects accrued (Crawford, 1985). Lymphocyte and neutrophil counts have been differentially affected by six weeks of ape-listening to specific imagery ins~uctions and