Abstract
Background Many molecular systems involved in controlling development are also implicated in malignant transformation and are associated with poorer survival outcomes in cancer patients. In fact, lung tumours with similar gene expression profiles to fetal lung cells are associated with aggressive phenotypes of the disease. As targeting fetal developmental pathways selectively reactivated in cancer cells would presumably spare normal adult cells from toxicity, these pathways are considered ideal therapeutic targets for cancer treatment. Therefore, a better understanding of the interplay between fetal lung development and lung cancer on the level of individual miRNAs will provide new insights for translational research. In this study we applied sequencing technology to identify miRNAs with similar expression patterns between fetal lung and lung tumours.
Highlights
Many molecular systems involved in controlling development are implicated in malignant transformation and are associated with poorer survival outcomes in cancer patients
Lung tumours with similar gene expression profiles to fetal lung cells are associated with aggressive phenotypes of the disease
As targeting fetal developmental pathways selectively reactivated in cancer cells would presumably spare normal adult cells from toxicity, these pathways are considered ideal therapeutic targets for cancer treatment
Summary
Open Access miRNA expression in human lung cancer and fetal lung: a comparative study. Daiana D Becker-Santos1,2*, Kelsie L Thu[1,2], Patricia P Reis[3], Wendy P Robinson[4], Stephen Lam[1], Wan L Lam[1]. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. 30 September - 6 October 2012
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