Surveillance Procedures Research Articles

Органы полиции Республики Корея

The article is dedicated to problems of police functioning in the Republic of Korea (the RK, Republic). The author mentions a number of documents that govern the activities of police of the Republic. South Korean police is in the structure of the Ministry of Public Administration and Security. The author analyzes the structure and competence of the National Police Agency. The article presents a detailed analysis of Korean laws on activities of national and autonomous police. The article shows how the state controls police through national and autonomous police committees. It is emphasized that police performs administrative as well as criminal intelligence, surveillance and criminal procedure activities. The author characterizes provisions on the status of police officers. Increased attention is paid to the liability of police officers.

Regulatory requirements for the approval of anti-cancer drugs as per CDSCO in India comparison with Singapore

This study examines the regulatory requirements for anticancer medications in Singapore and India are compared in this abstract. It draws attention to the frameworks set up by Singapore's Health Sciences Authority (HSA) and India's Central Drugs Standard Control Organization (CDSCO). The procedures for clinical studies, approval schedules, and post-marketing surveillance are among the main distinctions. Singapore places a strong emphasis on strict safety and efficacy criteria, whereas India stresses a quicker clearance process to address pressing healthcare needs. The investigation highlights how various regulatory methods affect patient access, innovation, and medicine supply in both nations. Recent decades have seen extraordinary improvements in the discovery of anticancer medications, transforming both cancer treatment and patient outcomes. With an emphasis on the main areas of anticancer therapeutics—chemotherapy, targeted therapy, immunotherapy, and hormone therapy—this study offers a thorough summary of the state of the field. We examine each drug class's methods of action, effectiveness, and difficulties while showcasing more recent developments like immune checkpoint inhibitors and CAR-T cell therapy. We also go over side effects, drug resistance, and how tailored medicine might improve the effectiveness of treatment. A look is also given to new developments in drug research, such as the application of nanotechnology and AI-driven drug discovery. The review attempts to shed light on the changing tactics used to fight cancer and the potential paths for anticancer medication development.

Vigilance, Popular Control and Neighborhood Surveillance in Besieged Paris (1589–1591)

Abstract Surveillance studies often recall that Michel Foucault had identified the health crises of the plagues of the Ancien Régime as precursory moments in the establishment of modern surveillance. Episodes of civil wars are certainly another example. This study takes for object the capital of the kingdom of France at the siege of Paris, in 1589–1591, when Henry III and then Henri IV tried to reduce to their authority in the rebellious city, head of the Ultra-Catholic Ligue. This unprecedented experience of fear and generalized suspicion allows us to study how the usual mechanisms of social control are used for political ends, but also how new surveillance procedures emerge, based on the written word and a desire for rationalization. This article uses a wide range of sources, from municipal decisions to the reports of chroniclers, but relies mainly on the judicial archives of the Parlement and the Hôtel de Ville to draw up a social history as close as possible to ordinary Parisians. Taking a ground-level approach, the study is particularly interested in ordinary agents of urban control and forms of day-to-day and face-to-face surveillance. In this exceptional climate, the routine work of watching others in the neighborhood turned to political surveillance. The key actors were the Militia, whose action relied on the Parisians themselves, considered as “the eyes and ears” of the League authorities to know who the enemies were and to testify of the loyalty of the inhabitants.

Automating execution of surveillance procedures for NPP main control rooms

ABSTRACT For the past 30 years, progress in the automation of control processes in the nuclear industry has been much slower compared to other industries. In the same timeframe, other complex industrial and/or high-risk processes (e.g., aviation) have been revolutionized by the exponential increase of technology capability in computing and information systems. The reason for the relatively slow trickling of technology advancements in the nuclear field is multi-faceted: i) resistance to change from a traditionally proven solution (partially due to very specific regulation requirements); ii) the cost to adopt Computerized Procedure Systems for existing NPPs, without having a quantified and proven safety benefit; iii) relatively low number of new NPPs being built following the Chernobyl and Fukushima disasters; iv) possible negative impact on the human factors aspect. After a short introduction to automation in another high-risk industry (aviation), this paper focuses on the practical approach required for automating Surveillance Procedures, and at the same time taking into consideration the human factors impact of this approach.

Why an EU country under the surveillance procedure (Article 7.1 TEU) should not chair the Council Presidency

AbstractMutual trust that is the bedrock of intra‐EU cooperation should not be equated to ‘blind trust’ when a Member State is under the ‘surveillance’ procedure foreseen by Article 7(1) of the Treaty on European Union. In this perspective it would be risky for the European Council to recognise a key coordinating role, as is the case when holding the Council Presidency, to a Member State under Article 7.1 TUE. It would then be sensible for the Council to modify its 2016 Decision, and delay the Hungarian Presidency of the Council of the European Union to such a time when the Article 7(1) TEU surveillance procedure will have been successfully concluded.

Compliance of Haditha Dam in Iraq to the International Standards for Surveillance and Monitoring

Dams are mega structures that retain huge volumes of water and their safety is important to national security, economy, and public interest. In this study, the types of regular measurements with their recorded value for Haditha Dam were checked for compliance with the standard international surveillance and monitoring procedures such as the procedures of the International Commission on Large Dams (ICOLD), the United States Bureau of Reclamation (USBR)and other to ensure safe dam operation and to avoid the scenario of the Derna Dam break, in Libya that occurred in September 2023. The result shows that the highest recorded settlement was found at station 41 on the left side of the dam body exceeding the design criteria (219 mm) by about 51 %, the frequency of measurement does not comply with the required international standards. There are 7 cells of pore pressure that exceeded the design criteria and the greatest percentage of exceedance was 21.57 % was found at pore pressure number 995. For piezometer reading, the percentage exceedance was 9.1% and it was found on the left side at piezometers number 58-8. The highest percentage of movement 62 % was found at join meter device number D18. The recorded seepage rate through the dam was found within the permitted limits. The visual inspection followed at Haditha Dam was not according to the standard required inspection.

Low Proportion of COVID-19 as an Occupational Disease among Tertiary Hospital Employees in Thailand

Objective: To examine the proportion of COVID-19 cases classified as an occupational disease and characterize COVID-19 among tertiary hospital employees (HEs) in Thailand. Materials and Methods: The present study was a retrospective descriptive study conducted between April 2021 and January 2022. Secondary data were obtained from electronic health records. In contrast, information on surveillance procedures was obtained from the hospital’s Occupational Health and Safety Management unit. The present study population included 115 HEs. Results: The proportion of COVID-19 cases classified as occupational diseases was 2.6% (3 out of 115). The most common sources of infection were household members at 40.0%, social events at 23.5%, and co-workers at 11.3%. If all healthcare employees were at risk, the estimated prevalence of COVID-19 during that period would be 115 out of 7,280, equivalent to 1.6 per 100 personnel. Among the infected HEs, more than half, or 55.7%, of the study population were frontline HEs. Most cases, or 41.7%, received a single booster vaccine and 76.9% had mild symptoms. None of the severe cases were immunized. Conclusion: The present study revealed a low proportion, at 2.6% of COVID-19 cases among HEs classified as occupational diseases. Their work activities contributed the least of causation. This may be due to effective strategies for hospital worker protection.

Empowering public health: building advanced molecular surveillance in resource-limited settings through collaboration and capacity-building.

The rapid detection and continuous surveillance of infectious diseases are important components of an effective public health response. However, establishing advanced molecular surveillance systems, crucial for monitoring and mitigating pandemics, poses significant challenges in resource-limited developing countries. In a collaborative effort, research institutions from Benin joined forces with Mali's National Institute of Public Health to implement a state-of-the-art molecular surveillance system in Mali. This approach was characterized by collaboration, multidisciplinarity, and tutoring. Key activities included a comprehensive assessment of infrastructure and human resources through document reviews, interviews, and laboratory visits; the development and validation of Standard Operating Procedures (SOPs) for advanced molecular surveillance following an inclusive approach; capacity-building initiatives for 25 biologists in Mali on sequencing techniques; and international tutoring sessions for eight Malian professionals held in Benin. These collective efforts enabled Mali to establish an advanced molecular surveillance system aligned with the WHO's global strategy for genomic surveillance. This manuscript aims to share experiences, insights, and outcomes from this initiative, with the hope of contributing to the broader discussion on strengthening global health security through collaborative approaches and capacity-building efforts, particularly in developing countries.

OBSTACLE OF COVID-19 DIGITAL SURVEILLANCE AT PUBLIC HEALTH CENTERS: EXPLORATORY STUDY IN WEST JAVA

Background: The quality of COVID-19 data from surveillance information systems is still an issue in low-middle-income countries (LMIC), including Indonesia, which uses various applications that have the potential to affect surveillance performance. Purpose: To explore the procedures and obstacles to using various digital surveillance applications at Public Health Centers (PHCs) in Indonesia. Methods: Qualitative research with exploratory studies was used. The setting was in the PHC in Kuningan, Majalengka, and Indramayu, City of Cirebon, Indonesia, with surveillance officer participants and contact tracer data manager, as many as 8. Data was collected by interviewing and using snowball sampling techniques between May 12 and 20, 2022. Data were analyzed using content analysis. Results: The initial data collection procedure involves obtaining data from various health facilities. Data recording was with SILACAK and the New All-Recorded application. Data analysis with descriptive epidemiology was reported to the head. Data quality was achieved with monitoring. Obstacles in data collection were rejection, community paradigm, and fear. The obstacles of the application are maintenance, not immediately updating that day, not entering at that time, sometimes it does not run smoothly, there are no tools for visualization, and data distribution per place not yet available. Conclusion: In COVID-19 surveillance procedures, from initial data collection, data recording, data analysis, data reporting, and data quality assurance, there are obstacles to data collection in the community and to applications used for surveillance. The District Health Office must compile new procedures that include data management stages, epidemiological data analysis, and visualization.

Assessment of fungal species in some spices using molecular study with detection of their mycotoxins using chromatography analysis.

Spices are food flavouring agents that are highly used in Iraq. However, they may be contaminated by toxicogenic fungi and subsequent production of mycotoxins. The aim of this study was to investigate the contamination of commonly used spices with fungi using polymerase chain reaction (PCR) assay and to detect fungal mycotoxin using high-performance liquid chromatography. Thirty-five spices (seven samples from each black pepper, red pepper, turmeric, cumin and ginger) were cultured on an appropriate medium to identify various fungi species. Later on, the toxigenicity of Aspergillus flavus and Aspergillus niger was determined using a PCR assay. The fungal mycotoxins, including aflatoxins and ochratoxins, were then determined through a high-performance liquid chromatography using the validated Quick, Easy, Cheap, Effective, Rugged, and Safe (QuECHERS) method. Aspergillus species were the predominantly isolated fungi, followed by Penicillium and Fusarium. The PCR results indicate the high toxigenicity of A. flavus as 85.7% of the strains had aflQ/aflR genes and 79% had PKS15KS/PKS15C-MeT genes. Regarding mycotoxin contamination in spices, the highest rates of aflatoxins and ochratoxins were found in black pepper (5.913 μg/kg) and red chilli (6.9055 μg/kg), respectively. Spices are susceptible substrates for the growth of mycotoxigenic fungi. Thus, regular effective surveillance and quality control procedures are highly recommended.

Adherence to follow-up and resource use after abnormal FIT-screening: Evaluation of the Danish colorectal cancer screening program.

Background and study aims The effectiveness of colorectal cancer screening programs depends on adherence to surveillance protocols for screening-positive individuals. We evaluated adherence in the Danish population-based screening program and estimated the volume of diagnostic resources required to achieve this adherence. Patients and methods In this register- and population-based study, we included individuals with a positive fecal immunochemical test (FIT) screening from 2014 to 2017 and followed them until mid-2022. All endoscopic, imaging, and surgical procedures performed at public and private hospitals were identified. Adherence to national protocols was reported in terms of proportions and timeliness. Use of diagnostic and surveillance procedures was estimated during a 4-year post-screening period. Results Among 82,221 individuals with a positive FIT test, 84% had a baseline colonoscopy within 1 month. After removal of intermediate or high-risk adenomas, 12% and 6%, respectively, did not have any follow-up. Only ~50% had timely surveillance. Approximately 10% to 20%, depending on their referral diagnosis, did not have a second surveillance colonoscopy. In addition, 12% with a negative colonoscopy had a second colonoscopy within 4 years. Conclusions High adherence to baseline colonoscopy after positive FIT-screening is followed by lower adherence throughout the adenoma surveillance program. Better adherence to the guidelines could potentially improve the effectiveness and efficiency of the screening program.

Surveillance colonoscopy findings in asymptomatic participants over 75 years of age.

Surveillance colonoscopy for colorectal cancer (CRC) is generally not recommended beyond 75 years of age. The study determined incidence and predictors of advanced adenoma and CRC in older individuals undergoing surveillance colonoscopy. This was a retrospective cohort study of asymptomatic older participants (≥75 years), enrolled in a South Australian CRC surveillance program who underwent colonoscopy (2015-2020). Clinical records were extracted for demographics, personal or family history of CRC, comorbidities, polypharmacy, and colonoscopy findings. The associations between clinical variables and advanced adenoma or CRC at surveillance were assessed with multivariable Poisson regression analysis. Totally 698 surveillance colonoscopies were analyzed from 574 participants aged 75-91 years (55.6% male). The incidence of CRC was 1.6% (11/698), while 37.9% (260/698) of procedures had advanced adenoma detected. Previous CRC (incidence rate ratio [IRR] 5.9, 95% CI 1.5-22.5), age ≥85 years (IRR 5.8, 95% CI 1.6-20.1) and active smoking (IRR 4.9, 95% CI 1.0-24.4) were independently associated with CRC diagnosis, while advanced adenoma at immediately preceding colonoscopy (IRR 1.6, 95% CI 1.3-2.0) and polypharmacy (IRR 1.2, 95% CI 1.0-1.5) were associated with advanced adenoma at surveillance colonoscopy in asymptomatic older participants (≥75 years). Advanced neoplasia was found in more than one third of the surveillance procedures completed in this cohort. Continuation of surveillance beyond age 75 yeasrs may be considered in participants who have previous CRC or are active smokers (provided they are fit to undergo colonoscopy). In other cases, such as past advanced adenoma only, the need for ongoing surveillance should be considered alongside participant preference and health status.

Cholera and diarrheal diseases in Cuamba District, Niassa Province, Mozambique: Systematic healthcare facility-based surveillance strengthening, characteristics of suspected cholera and diarrheal patients, and incidence of diarrheal diseases.

Mozambique is one of the countries in Africa that is continuously at risk of cholera outbreaks due to poor sanitation, hygiene, and limited access to potable water in some districts. The Mozambique Cholera Prevention and Surveillance (MOCA) project was implemented in Cuamba District, Niassa Province to prevent and control cholera outbreaks through a preemptive cholera vaccination, strengthened surveillance system for cholera and diarrheal diseases, and better understanding of cholera-related healthcare seeking behavior of local populations, which may further guide the national cholera control and prevention strategies. This article presents the surveillance component of the MOCA project. A prospective healthcare facility (HCF)-based surveillance of cholera and diarrheal disease was conducted in six HCFs in the District of Cuamba from March 2019 to December 2020. A systematic surveillance procedure has been put in place with capacity building in selected sentinel HCFs and a basic microbiology laboratory established on-site. Patients presenting with suspected cholera or other diarrheal symptoms were eligible for enrollment. Clinical data and rectal swab samples were collected for laboratory confirmation of Vibrio Cholerae and other pathogens. A total of 419 eligible patients from six HCFs were enrolled. The median age was 19.8 years with a similar age distribution between sentinel sites. The majority were patients who exhibited diarrhea symptoms not suspected of cholera (88.8%; n = 410). Among those, 59.2% (210/397) were female and 59.9% (235/392) were 15 years and above. There were 2 cholera cases, coming outside of the catchment area. The incidence of diarrheal diseases ranged from 40-103 per 100,000 population. No Vibrio cholerae was isolated among surveillance catchment population and Escherichia coli spp. (82/277; 29.6%) was the most common pathogen isolated. Efforts were made to strengthen the systematic surveillance of suspected cholera with standardised patient screening, enrolment, and diagnostics. The first basic microbiology laboratory in Niassa Province established in Cuamba District under the MOCA project needs to be integrated into the national network of laboratories for sustainability. No reports of laboratory confirmed cholera cases from the surveillance catchment area may be highly related to the pre-emptive oral cholera vaccine (OCV) mass vaccination campaign conducted in 2018 and the use of drugs by local populations prior to visiting the sentinel HCFs. Continued systematic cholera surveillance is needed to closely monitor the cholera endemicity and epidemics, and further evaluate the long-term impact of this vaccination. High incidence of diarrheal illnesses needs to be addressed with improved water, sanitation, and hygiene (WaSH) conditions in Cuamba District. Efforts integrated with the prioritization of prevention measures are fundamental for the control of cholera in the country.

The relationship between executive function and the association of motor coordination difficulties and social communication deficits in autistic children.

Motor coordination difficulties could contribute to social communication deficits in autistic children. However, the exploration of the mechanism implicated in these claims has been limited by the lack of potential confounders such as executive function (EF). We investigated the role that EF plays in the relationship between motor coordination and social communication in a school-aged autistic population via a structural model in a statistically robust manner. The results of questionnaires, including the Developmental Coordination Disorder questionnaire, the Behavior Rating Inventory of Executive Function, and the Social Responsiveness Scale, were collected to measure motor coordination, social communication deficits, and EF. A total of 182 autistic children (7.61±1.31 years, 87.9% boys) were included in the final analysis. In the model with EF as a mediator, the total effect (β=-0.599, P<0.001) and the direct effect (β=-0.331, P =0.003) of motor coordination function on social communication were both significant among autistic children without intellectual disability (ID), as were indirect effects through EF (β=-0.268, P<0.001). EF partially mediates the motor coordination and social communication correlation among autistic children. We suggest that motor coordination should be included in the routine evaluation of autistic surveillance and rehabilitation procedures.

Preterm Birth Following Active Surveillance vs Loop Excision for Cervical Intraepithelial Neoplasia Grade 2

Active surveillance for cervical intraepithelial neoplasia grade 2 (CIN2) is being implemented in many high-income countries due to the association of excisional treatment with preterm birth. However, it is unknown whether active surveillance results in lower risk of preterm birth given that cervical dysplasia itself is associated with higher risk of preterm birth. To compare the preterm birth risk between women with CIN2 undergoing active surveillance or immediate loop electrosurgical excision procedure (LEEP). This historical population-based cohort study included women with a first-time diagnosis of CIN2 and a subsequent singleton birth from 1998 to 2018 in Denmark. Women with prior CIN grade 3 or greater or LEEP were excluded. Data were collected from 4 Danish health care registries. Analyses were conducted from October 2022 to June 2023. Women were categorized into active surveillance (cervical biopsy and/or cytology) or immediate LEEP based on their first cervical sample after CIN2 diagnosis. The active surveillance group was further subdivided based on whether a delayed LEEP was performed within 28 months from CIN2 diagnosis. Risk of preterm birth (<37 + 0 weeks) was assessed and relative risks (RRs) were calculated using modified Poisson regression. Analyses used inverse probability treatment weighting of the propensity scores to adjust for age, parity, calendar year, index cytology, and smoking. A total of 10 537 women with CIN2 and a singleton birth were identified; 4430 (42%) underwent active surveillance and 6107 (58%) were treated with immediate LEEP. For both groups, most were aged 23 to 29 years at CIN2 diagnosis (3125 [70%] and 3907 [64%], respectively). Overall, 869 births (8.2%) were preterm. The risk of preterm birth was comparable between active surveillance and immediate LEEP (RR, 1.03; 95% CI, 0.90-1.18). However, for women undergoing delayed LEEP after active surveillance (1539 of the active surveillance group [35%]), the risk of preterm birth was higher than for women treated with immediate LEEP (RR, 1.29; 95% CI, 1.08-1.55). In this cohort study of women with CIN2, the risk of preterm birth was comparable between active surveillance and immediate LEEP. However, delayed LEEP was associated with 30% higher risk of preterm birth than immediate LEEP. Thus, risk stratification at CIN2 diagnosis is important to identify women with increased risk of delayed LEEP.

Diameter and dissection of the abdominal aorta and the risk of distal aortic reoperation after surgery for type A aortic dissection

BackgroundSurgery for Stanford type A aortic dissection (TAAD) is associated with an increased risk of late aortic reoperations due to degeneration of the dissected aorta. MethodsThe subjects of this analysis were 990 TAAD patients who survived surgery for acute TAAD and had complete data on the diameter and dissection status of all aortic segments. ResultsAfter a mean follow-up of 4.2 ± 3.6 years, 60 patients underwent 85 distal aortic reoperations. Ten-year cumulative incidence of distal aortic reoperation was 9.6%. Multivariable competing risk analysis showed that the maximum preoperative diameter of the abdominal aorta (SHR 1.041, 95%CI 1.008–1.075), abdominal aorta dissection (SHR 2.133, 95%CI 1.156–3.937) and genetic syndromes (SHR 2.840, 95%CI 1.001–8.060) were independent predictors of distal aortic reoperation. Patients with a maximum diameter of the abdominal aorta >30 mm and/or abdominal aortic dissection had a cumulative incidence of 10-year distal aortic reoperation of 12.0% compared to 5.7% in those without these risk factors (adjusted SHR 2.076, 95%CI 1.062–4.060). ConclusionTAAD patients with genetic syndromes, and increased size and dissection of the abdominal aorta have an increased the risk of distal aortic reoperations. A policy of extensive surgical or hybrid primary aortic repair, completion endovascular procedures for aortic remodeling and tight surveillance may be justified in these patients.Trial registration:ClinicalTrials.gov Identifier: NCT04831073.

Short-term patency of iliofemoral to tibial bypass with vascular allografts in a minority population: A retrospective analysis of a single center acute care facility.

The aim of this study was to examine the short-term patency rates and associated factors of open lower limb, iliofemoral to tibial bypass using cryopreserved saphenous vein (CSV) in a minority population at an acute care hospital in New York City. A retrospective analysis of patients undergoing infra-inguinal bypass from iliofemoral vessels to tibial arteries with CSV between March 2020-April 2022 at an acute care facility (Harlem Hospital Center, Harlem, New York) was performed. Data including patient demographics, comorbidities, type of operation, follow-up surveillance, and salvage procedures were collected. Results were presented in patency line graphs and a life table. Target limb revascularization (TLR) and amputation free survival (AFS) were also calculated. Eleven bypass procedures were included in the analysis. Patients were followed for a mean of 10.8months. Cumulative primary patency rates at 1, 6, and 12months were 72.7%, 54.5%, and 40.9%, respectively. TLR was 36.4% and the AFS was 66.67% at the mean 10.8-month follow-up. The patency rates of minority patients undergoing bypass with CSV were analyzed with creation of a life table and calculation of patency rates, TLR and AFS. The short-term primary patency rates and post-operative outcomes were found to be comparable to larger studies in non-minority cohorts. These results suggest that larger studies as well as prospective analyses and randomized controlled trials in this patient cohort and demographic are needed, as well as optimal selection of patients to determine true clinical implications.

Rapid detection of high consequence and emerging viral pathogens in pigs.

An increasing emergence of novel animal pathogens has been observed over the last decade. Viruses are a major contributor to the increased emergence and therefore, veterinary surveillance and testing procedures are greatly needed to rapidly and accurately detect high-consequence animal diseases such as Foot and Mouth Disease, Highly Pathogenic Avian Influenza, Classical Swine Fever, and African Swine Fever. The major detection methods for such diseases include real-time PCR assays and pathogen-specific antibodies among others. However, due to genetic drift or -shift in virus genomes, failure to detect such pathogens is a risk with devastating consequences. Additionally, the emergence of novel pathogens with no prior knowledge requires non-biased detection methods for discovery. Utilizing enrichment techniques coupled with Oxford Nanopore Technologies MinION™ sequencing platform, we developed a sample processing and analysis pipeline to identify DNA and RNA viruses and bacterial pathogens from clinical samples. The sample processing and analysis pipeline developed allows the identification of both DNA and RNA viruses and bacterial pathogens simultaneously from a single tissue sample and provides results in less than 12 h. Preliminary evaluation of this method using surrogate viruses in different matrices and using clinical samples from animals with unknown disease causality, we demonstrate that this method can be used to simultaneously detect pathogens from multiple domains of life simultaneously with high confidence.

The diagnostic yield of colonoscopic surveillance following resection of early age onset colorectal cancer.

The primary benefit of post-colorectal cancer (CRC) colonoscopic surveillance is to detect and remove premalignant lesions to prevent metachronous CRC. Current guidelines for long-term colonoscopic surveillance post early age onset CRC (EOCRC) resection are based on limited evidence. The aims of this study were to assess the diagnostic yield of colonoscopic surveillance post-EOCRC resection and identify molecular and clinicopathological risk factors associated with advanced neoplasia. A retrospective cohort study of prospectively collected data was conducted at St Mark's hospital, London, United Kingdom, for patients diagnosed with EOCRC who underwent at least one episode of post-CRC colonoscopic surveillance between 1978 and 2022. We collected clinicopathological data including tumour molecular status and neoplasia detection rates. In total, 908 colonoscopic surveillance procedures were performed in 195 patients over 2581.3 person-years of follow-up. The diagnostic yields of metachronous CRC, advanced adenomas and non-advanced adenomas were 1.76%, 3.41% and 22.69% respectively. Sixteen patients (8.21%) developed metachronous CRC, and the majority (87.5%) were detected more than 3years post index EOCRC diagnosis. Detection of advanced neoplasia was significantly higher in EOCRC patients with Lynch syndrome (26.15%) compared with those in whom Lynch syndrome was excluded (13.13%) (OR, 2.343; 95% CI, 1.014-5.256; p=0.0349). During colonoscopic surveillance post-EOCRC resection, the long-term risk of developing metachronous advanced neoplasia remains high in the context of Lynch syndrome, but this trend is not as clearly evident when Lynch syndrome has been excluded.

HIV epidemiological surveillance in Ecuador, a review bibliography

Introduction: the human immunodeficiency virus (HIV) is characterized by attacking TCD4 cells and macrophages; with the progression of the pathology, secondary infections can develop. Objetive: to describe the theoretical foundations of the HIV epidemiological surveillance system in Ecuador. Methods: research based on bibliographic review in different databases, Epidemiological Gazettes, SIVE-ALERTA Manuals and websites of Scientific Knowledge Organizations, the PICOT question was also implemented and 25 articles based on the PRISMA method were used. Results: the surveillance procedure is based on universal surveillance with different diagnostic methods, notified through EPI INFO-SIGEPI databases registered with the Ministry of Public Health. The total number of infections in Ecuador in 2022 is 48,924, with a higher incidence in the province of Napo with 0,67 and new cases in the province of Guayas with 32,5 %. Conclusion: information from different databases on the incidence, prevalence, morbidity, mortality and opportunistic infections of the HIV virus was synthesized