The purpose of this study was to investigate the epidemiology of malignant tumors found in the oral and maxillofacial region of patients who visited institutions certified as training facilities by the Japanese Society of Oral and Maxillofacial Surgeons in Japan. A questionnaire was sent to 234 institutions and those returned with medical records were used to create an epidemiological database of oral cancer patients who visited the affiliated oral surgery institutions in Japan in 2002. A total of 2128 patients records were returned, of which 1809 were evaluated. They represented patients treated at 148 institutions, including 39 dental university hospitals, 44 medical university hospitals, 64 general hospitals, and 1 other institution. Among the 1809 cases, 6 patients had intraoral multiple cancerous tumors (5 patients with 2 cancerous tumors, 1 with 3), thus a total of 1816 tumors were evaluated. The patients consisted of 1071 (59.2%) males and 738 (40.8%) females (male:female ratio, 1.45:1), who had a mean age of 65.2 years old (SD: 13.9). The tongue (40.2%) was the most common site affected, followed by the gingiva (32.7%), buccal mucosa (10.1%), and oral floor (9.0%). In histopathological examinations, squamous cell carcinoma (88.7%) was the most common type found, followed by adenoid cystic carcinoma (2.1%), and mucoepidermoid carcinoma (1.7%). In addition, non-epithelial tumors comprised 1.8%, of which malignant melanoma was the most common type. Cases classified as T2N0 were the most common (32.1%), followed by T1N0 (21.4%), T4N0 (8.0%), and T2N1 (7.6%). Distant metastasis occurred in 17 patients (1.0%). The sizes of the non-epithelial malignant tumors ranged from 1.0 to 7.0 cm, with a mean size of 3.7 cm. In Japan, tongue cancer is the most prevalent type of oral cancer. In the present series, histopathological examinations showed that squamous cell carcinoma was the most common, and stage 1 and 2 cases accounted for half of the patients. Nevertheless, nearly half of the patients had advanced carcinomas. These results indicate the importance of early recognition of oral malignancy.
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