This study investigates the drilling operation on Inconel 718 superalloy by using cryogenic treated drill bit. Thrust force, torque and surface roughness are analyzed to understand the effects of the cryogenic condition during CNC drilling operation. Taguchi’s methodology has been employed for planning of experiments. Drill bits are conditioned under two different environment i.e. cryogenically treated with single tempered and cryogenically treated with double tempered. The process parameters are optimized by using Whale optimization algorithm for obtaining minimized surface roughness along with maximization of torque and thrust force during drilling operation. The ANOVA results show that feed rate is the most contributing significant factor for thrust for its maximization while spindle speed is the most contributing significant factor for torque for its maximization. Also, tool condition is the most contributing significant factor for surface roughness for its minimization. Lastly, confirmatory test were conducted to find out the significance of the predicted values obtained using the optimization methods.