Abstract Stretchable printed circuit boards (S-PCBs) offer unique advantages over rigid PCBs such as enabling conformability to changing environments and ergonomic designs with increased lifetime under dynamic loads. This study introduces an innovative fabrication method and a cost-effective solution for rapid prototyping S-PCBs using commercially available materials. By utilizing silicone substrates with different levels of stiffness and structured copper sheets for electrical connections, the S-PCBs feature ‘stiff islands’ embedded in a flexible base material. This fabrication method helps alleviate mechanical strain on strain-sensitive components while allowing local deformation of the S-PCB. The proposed fabrication method does therefore enable to integrate surface mount device components into S-PCBs and facilitates complex circuit designs while maintaining stretchability and fatigue resistance. Through material characterization, video strain analysis, as well as quasi-static and cyclic loading tests, this article demonstrates the efficacy of our approach. Based on the experimental results, we provide insights into failure modes and suggest design principles to further enhance the durability of S-PCBs fabricated with our method. We then conclude by presenting a soft wearable S-PCB demonstrator. The S-PCBs fabricated with this method withstood mechanical strains up to 100% and cyclic loads with 30% strain up to 625 cycles. The results are very promising for applications in soft robotics, wearable devices, and soft sensors and actuators. Overall, our study offers a comprehensive toolkit for fast S-PCB prototyping, paving the way for advancements in stretchable electronics with a high degree of complexity and stretchability.