Suppression Of Amplitude Research Articles

Experimental exploration of unpowered propellers for vortex-induced vibration suppression of flexible riser

Passive control of the vortex-induced vibrations (VIVs) of flexible risers has been typically studied to alleviate their VIV responses by means of breaking the spanwise correlation, modifying the structural characteristic, or disturbing the flow field. However, this paper proposed using innovative suppression devices—unpowered propellers—to mitigate VIVs and output energy through passive rotation under flowing fluids. The effectiveness of three-, four-, and six-blade propellers for VIV suppression was experimentally examined in the Reynolds number range of 2600–10,400. Seven identical propellers were installed uniformly along a riser facing the incoming flow for VIV suppression. The response parameters of the riser models, including the displacement, frequency, trajectory, and fatigue damage, were investigated. Moreover, a comprehensive evaluation of the unpowered propellers, determined by the suppression efficiency and the cost, was also conducted. The experimental results showed that all three types of propellers significantly decreased the VIV amplitudes and inhibited high-order frequency components. Increasing the number of blades effectively enhanced the amplitude suppression of the propellers, whereas it had almost no effect on the vibration frequencies of the controlled risers. It is worth noting that the three-blade propellers with the best comprehensive evaluation may not be a reasonable choice in high-velocity water.

Experimental investigation on the effectiveness of serrated helical strakes in suppressing vortex-induced vibrations for a flexible riser

The effectiveness of an unconventional configuration of serrated helical strakes (SSs) in alleviating the vortex-induced vibrations (VIVs) of flexible risers was evaluated experimentally in the Reynolds number range of 2600–10,400. Five SSs with varying serration densities and lengths were designed and compared with conventional strakes (CSs) to highlight the unparalleled features of this new geometry. The VIV parameters of the bare and straked risers, including the displacement, frequency, fatigue damage, and suppression efficiency, were systematically investigated. The comprehensive evaluation of the helical strakes was also made considering the factors of amplitude suppression, frequency inhibition, drag force, and cost control. The experimental results confirmed that all the helical strakes were capable of suppressing the VIV responses of flexible riser models. With identical strake areas, the SSs were more effective in inhibiting the VIV amplitude and fatigue damage than the CSs; whereas, the serrated geometry had few effects in improving the reduction of VIV frequency. Moreover, serration density is a critical factor in determining the suppression performance of SSs under the same strake heights and areas. An increase in the strake area enhanced VIV suppression performance; however, excess strakes deteriorated the comprehensive evaluation index due to the increased cost.

The galaxy power spectrum on the lightcone: deep, wide-angle redshift surveys and the turnover scale

We derive expressions for the survey-window convolved galaxy power spectrum in real space for a full sky and deep redshift survey, but taking into account the geometrical lightcone effect. We investigate the impact of using the standard mean redshift approximation as a function of survey depth, and show that this assumption can lead to both an overall amplitude suppression and scale-dependent error when compared to the 'true' spectrum. However, we also show that by using a carefully chosen 'effective fixed-time', one can find a range of scales where the approximation to the full model is highly accurate, but only on a more restricted set of scales. We validate the theory by constructing dark matter and galaxy lightcone mock surveys from a large N-body simulation with a high cadence of snapshots. We do this by solving the light cone equation exactly for every particle, where the particle worldlines are obtained in a piecewise fashion with cubic interpolation between neighbouring snapshots. We find excellent agreement between our measurements and the theory (∼ ±5%) over scales (0.004 h Mpc-1 ≤ k ≤ 0.54 h Mpc-1) and for a variety of magnitude limits. Finally, we look to see how accurately we can measure the turnover scale of the galaxy power spectrum k 0. Using the lightcone mocks we show that one can detect the turnover scale with a probability P ≥ 95% in an all-sky catalogue limited to an apparent magnitude m lim ∼ 21. We also show that the detection significance would remain high for surveys with m lim ∼ 22 and 20% sky coverage.

Estimating asymptotic phase and amplitude functions of limit-cycle oscillators from time series data.

We propose a method for estimating the asymptotic phase and amplitude functions of limit-cycle oscillators using observed time series data without prior knowledge of their dynamical equations. The estimation is performed by polynomial regression and can be solved as a convex optimization problem. The validity of the proposed method is numerically illustrated by using two-dimensional limit-cycle oscillators as examples. As an application, we demonstrate data-driven fast entrainment with amplitude suppression using the optimal periodic input derived from the estimated phase and amplitude functions.

P.100 Early recognition of unique conventional and amplitude-integrated EEG patterns and clinical semiology of neonatal seizures caused by SCN2A and KCNQ3 mutations

Background: Early recognition of neonatal seizures secondary to pathogenic variants in potassium or sodium channel coding genes is crucial, as these seizures are often resistant to commonly used anti-seizure medications, but respond well to sodium-channel blockers. We report a unique aEEG pattern in neonatal seizures caused by SCN2A and KCNQ3 pathogenic variants, as well as adding regular EEG description. Methods: International multicentre descriptive study, reporting clinical characteristics, aEEG and conventional EEG findings of 10 newborns with seizures due to pathogenic SCN2A and KCNQ3 gene variants. Results: Seizures started in the first postnatal week. Seizure semiology typically included tonic posturing with apnea and desaturation. The aEEG showed a characteristic sequence of brief onset with a decrease, followed by a quick rise, and then postictal amplitude attenuation. This pattern correlated with bilateral attenuation in the EEG at onset, followed by rhythmic discharges ending in several seconds of post-ictal amplitude suppression. The majority of patients became seizure free upon initiation of a sodium-channel blocker. Conclusions: Neonatal seizures caused by SCN2A and KCNQ3 mutations can be recognized by a characteristic ictal aEEG pattern and clinical semiology. Awareness of this pattern facilitates the prompt initiation of precision treatment with sodium-channel blockers even before genetic test results are available.

Nonlinear Dynamics of an Elastic Stop System and Its Application in a Rotor System

Impact dampers or vibration systems with gaps are common in engineering applications, and the impact effects introduced by the gaps make such systems strongly nonlinear. In this paper, a model with an elastic stop is established, considering the stiffness and damping characteristics of the stop, which is a novel kind of impact damper and can be applied in a rotor system. The amplitude–frequency and phase–frequency response of the system at different gaps are obtained by the harmonic balance method with the alternating frequency–time scheme (HBM-AFT). The stability of the periodic solution is analyzed by the Floquet theory, and the time history and frequency spectra of the unstable point are analyzed by the numerical integration method. In the results, there can be more than one steady-state response at unstable points for a given excitation frequency, and the jump phenomenon occurs. The elastic stop is effective in the vibration amplitude suppression if its stiffness has been designed properly. This study provides an insight into the dynamic responses and its applications of the system with gaps, which is guidance for the analysis of pedestal looseness faults and vibration suppress methods.

Robust Control of a Biophysical Model of Burst Suppression

Abstract Burst suppression is a phenomenon in which the electroencephalogram (EEG) of a pharmacologically sedated patient alternates between higher frequency and amplitude bursting to lower frequency and amplitude suppression. The level of sedation can be quantified by the burst suppression ratio (BSR), which is defined as the amount of time that an EEG is suppressed over the amount of time measured. Maintaining a stable BSR in patients is an important clinical problem, which has led to an interest in the development of BSR-based closed-loop pharmacological control systems. Methods to address the problem typically involve pharmacokinetic (PK) modeling that describes the dynamics of drug infusion in the body as well as signal processing methods for estimating burst suppression from EEG measurements. In this regard, simulations, physiological modeling, and control design can play a key role in producing a solution. This paper seeks to add to prior work by incorporating a Schnider PK model with the Wilson–Cowan neural mass model to use as a basis for robust control design of biophysical burst suppression dynamics. We add to this framework actuator modeling, real-time burst suppression estimation, and uncertainty modeling in both the patient's physical characteristics and neurological phenomena to form a closed-loop system. Using the Ziegler–Nichols tuning method for proportional-integral-derivative (PID) control, we were able to control this system at multiple BSR set points over a simulation time of 18 h in both nominal, patient varied with noise added and with reduced performance due to BSR bounding when including patient variation and noise as well as neurological uncertainty.

Stochastic dynamics of vortex-acoustic lock-in: stochastic bifurcation and resonance

We perform a theoretical study to understand vortex-acoustic lock-in in the presence of an additive Gaussian white noise using a lower-order model. The acoustic field is realized as an external harmonic excitation. Frequency, harmonic excitation and noise amplitudes are varied over ranges encountered in practical and lab-scale combustors. Probability density functions (PDFs) for shedding time periods and phase instants are obtained in the Fokker–Planck framework. Unlike the general scenario, where stochastic bifurcation is identified by a qualitative change in the stationary PDFs, in this case, stochastic lock-in is identified by a qualitative change in the spectrum of the transition probability matrix. The effect of the noise is to reduce the extent of lock-in while preserving the underlying deterministic dynamical features. Although various orders of lock-in are identified, 1 : 1 stochastic lock-in with the excitation frequency close to the natural vortex shedding frequency is found to be the most favourable condition for combustion instability to occur. We show that lock-in can be accompanied by both instability and amplitude suppression. Stochastic resonance is also observed; however, its contribution to instability is marginal.

Investigation of damping characteristics onPLArobotic gripper fingers with magnetorheological fluid core and unimorph piezoelectricMFC

AbstractPolylactic acid (PLA) is an environmentally friendly, biodegradable, and low‐cost thermoplastic material suitable for 3D printing. Complex shapes can be easily produced and hence PLA has been used for many applications. This study presents the damping characteristics of two robotic gripper fingers. The first gripper is composed of a PLA surface layer and a magnetorheological (MR) fluid core and the second gripper is composed of a PLA surface layer bonded to a surface of unimorph piezoelectric Macro Fiber Composite (MFC). The magnetic field is applied by using permanent magnets while the magnetic field strength is varied by changing the distance between the permanent magnets. The electric field is applied by using a micro‐amplifier and regulated using data acquisition systems. The natural frequency and damping ratio of the PLA gripper finger are determined by free vibration analysis using LabVIEW software. The damping ratio and vibration amplitude suppression for the PLA grippers was increased as the magnetic field strength changed from 0G to 600G (MR) and as the electric field changed from 0V to 360V (MFC).

Detection method for surface scratches of composite automotive components with high reflection and complicated background color

Abstract Current testing status have the problems that the surface background color pattern of high reflective carbon fiber auto parts is complex, the shape of scratch defects is irregular, and the shallow and micro scratches are not easy to be detected. Aiming at the problems, a scratch detection method combining innovative morphological processing and optimized Canny edge detection algorithm is proposed. The image acquired by an innovative image acquisition platform. After gray processing and open operation denoising, the self-defined oval kernel secondary expansion is introduced in the morphological processing part. When threshold segmentation and minimum connected domain screening are done, the optimized Canny edge detection algorithm is used. Through the non-maximum suppression of gradient amplitude, a wide range of dual-threshold parameters are selected to detect the edge of the target image. The results show that the detection rate of the proposed method is 18.57% higher than that of the traditional way, and the detection rate is up to 95.71%. At the same time, the proposed method can reflect the scratch morphology more intuitively.

Recovery of harmonic-like behavior of the polar mode in BaTiO3 at high pressures

The local structure of high pressure BaTiO$_3$ has been interrogated by neutron total scattering methods, up to pressures of 4.18 GPa at ambient temperature. Competitive refinements of cubic, tetragonal and rhombohedral distortion modes against pair distribution functions indicate contrasting local structure behaviour of temperature- and pressure-induced cubic BaTiO$_3$. Suppression of the mode amplitude, isotropy of the order parameter direction and loss of sensitivity to correlated Ti displacements at high pressure all suggest a high-pressure local structure that is more consistent with the harmonic approximation, rather than an order-disorder model which better describes high-temperature cubic BaTiO$_3$ in the vicinity of the tetragonal phase transition.

Terahertz Spin-Current Pulses from an Off-Resonant Antiferromagnet

The generation of terahertz (THz) spin current is highly desired for enhancing the speed and efficiency of information manipulation by ultrafast spintronics. We develop an analytical model to investigate the coherent and pure spin-current pulses generated by spin pumping in a canted insulating antiferromagnet (AFM) system with Dzyaloshinskii-Moriya interaction (DMI). As expected, the spin pumping signal is significant at resonance. However, we also predict efficient THz spin-current transient with a magnitude comparable with that of its resonant counterparts in the much higher off-resonance THz frequency regime. Its ultrafast temporal change compensates for the suppression of the dynamic magnetization amplitudes at off-resonance. In addition, a stronger DMI field enhances the amplitude of the spin-current transient. Our results represent an efficient approach to generate coherent THz spin-current pulses based on canted AFM heterostructures without requiring a static magnetic field.

Hybrid active flow induced vibration control of a circular cylinder equipped with a wake-mounted smart piezoelectric bimorph splitter plate

A two-dimensional numerical study on active flow induced vibration (FIV) suppression of an elastically suspended circular cylinder fitted with a thin smart flexural-mode (bender-type) piezoelectric bimorph splitter plate on its wake side in real-time collaboration with a conventional base force actuator is carried out in laminar cross-flow condition (Re=100) for a wide range of reduced flow velocities (4≤U∗≤40). The numerical model is based on a strongly-coupled partitioned two-way iteratively implicit Fluid–Structure Interaction (FSI) routine implemented in a multiphysics simulation framework that interactively connects a CFD-based finite volume solver with a nonlinear transient computational structural dynamics (CSD) finite-element solver. A single-input-multi-output (SIMO) direct displacement feedback control law is introduced into the coupled transient dynamic simulation framework through an internal subroutine written in APDL command language. Three distinct feedback control configurations are implemented and compared, namely, the force-actuated, the piezo-actuated, and the hybrid actuation control systems, primarily aiming at suppression of cylinder transverse displacement amplitude. Further improvements on the controller performance are achieved by incorporating two modified hybrid actuation control strategies particularly designed for mitigation of excessive temporal oscillations of the drag and lift coefficients. Extensive numerical simulations reveal the important effects of splitter plate length, reduced velocity, and controller configuration on the key structural/flow-field parameters and flow structure. The hybrid actuation control configurations are found to provide a largely better displacement response control performance than the single-alone force-actuated or piezo-actuated systems. Also, the overall success of the modified hybrid control strategies in effective alleviation of the highly erratic lift and drag forces experienced by the smart cylinder-plate assembly is demonstrated. Lastly, it is concluded that if one primarily aims at prompt and forceful suppression of the base cylinder motion regardless of lift and drag force variations, the originally designed hybrid actuation control system is sufficiently adequate, while if one is specifically concerned with the severe temporal fluctuations in the lift and drag coefficients, the modified hybrid control configurations should be employed.

The vortex-induced vibration of an elliptic cylinder with different aspect ratios

This study investigates the hydrodynamic characteristics of an elastically-mounted elliptic cylinder at low mass ratio m*=2 and low damping ratio ζ=0.007. The aspect ratio (AR) defined by the characteristic length in the streamwise and transverse direction varies in the range 0.5≤AR≤2.0. The dynamic response is characterized as a function of reduced velocity. The streamlined profile of the elliptic cylinder results in a delay of the vortex shedding and a diminished strength of the averaged vorticity. However, the hydrodynamic characteristics become more complicated for large ARs. Both the response amplitude and the hydrodynamic forces acting on the cylinder are enhanced as the afterbody is reduced. The PSD behaviors show the existence of four different flow regimes. Several new pertinent modes, such as 2 Po*, 2T*, etc., are captured through flow visualizations. A comprehensive analysis of the vortex shedding indicates the sub-vortices generated at the rear of the cylinder plays a key role in the formation and evolution wake modes. Besides, the time-averaged vorticity magnitude at the vortex core elucidate that despite secondary vortices account for a large proportion of the primary vortices, they only make a small contribution to the suppression of the vibration amplitude.

Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes

Many small molecule kinase inhibitors (SMKIs), used predominantly in cancer therapy, have been implicated in serious clinical cardiac adverse events, which means that traditional preclinical drug development assays were not sufficient for identifying these cardiac liabilities. To improve clinical cardiac safety predictions, the effects of SMKIs targeting many different signaling pathways were studied using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) in combined assays designed for the detection of both electrophysiological (proarrhythmic) and non-electrophysiological (non-proarrhythmic) drug-induced cardiotoxicity. Several microplate-based assays were used to quantitate cell death, apoptosis, mitochondrial damage, energy depletion, and oxidative stress as mechanism-based non-electrophysiological cardiomyocyte toxicities. Microelectrode arrays (MEA) were used to quantitate in vitro arrhythmic events (iAEs), field potential duration (FPD) prolongation, and spike amplitude suppression (SAS) as electrophysiological effects. To enhance the clinical relevance, SMKI-induced cardiotoxicities were compared by converting drug concentrations into multiples of reported clinical maximum therapeutic plasma concentration, “FoldCmax”, for each assay. The results support the conclusion that the combination of the hPSC-CM based electrophysiological and non-electrophysiological assays have significantly more predictive value than either assay alone and significantly more than the current FDA-recommended hERG assay. In addition, the combination of these assays provided mechanistic information relevant to cardiomyocyte toxicities, thus providing valuable information on potential drug-induced cardiotoxicities early in drug development prior to animal and clinical testing. We believe that this early information will be helpful to guide the development of safer and more cost-effective drugs.

Kinetics and Connectivity Properties of Parvalbumin- and Somatostatin-Positive Inhibition in Layer 2/3 Medial Entorhinal Cortex.

Parvalbumin-positive (Pvalb+) and somatostatin-positive (Sst+) cells are the two largest subgroups of inhibitory interneurons. Studies in visual cortex indicate that synaptic connections between Pvalb+ cells are common while connections between Sst+ interneurons have not been observed. The inhibitory connectivity and kinetics of these two interneuron subpopulations, however, have not been characterized in medial entorhinal cortex (mEC). Using fluorescence-guided paired recordings in mouse brain slices from interneurons and excitatory cells in layer 2/3 mEC, we found that, unlike neocortical measures, Sst+ cells inhibit each other, albeit with a lower probability than Pvalb+ cells (18% vs 36% for unidirectional connections). Gap junction connections were also more frequent between Pvalb+ cells than between Sst+ cells. Pvalb+ cells inhibited each other with larger conductances, smaller decay time constants, and shorter delays. Similarly, synaptic connections between Pvalb+ and excitatory cells were more likely and expressed faster decay times and shorter delays than those between Sst+ and excitatory cells. Inhibitory cells exhibited smaller synaptic decay time constants between interneurons than on their excitatory targets. Inhibition between interneurons also depressed faster, and to a greater extent. Finally, inhibition onto layer 2 pyramidal and stellate cells originating from Pvalb+ interneurons were very similar, with no significant differences in connection likelihood, inhibitory amplitude, and decay time. A model of short-term depression fitted to the data indicates that recovery time constants for refilling the available pool are in the range of 50–150 ms and that the fraction of the available pool released on each spike is in the range 0.2–0.5.

Evaluation of Medial Olivocochlear Neural Efferent Pathway in Tinnitus Perception in Normal-hearing Individuals.

The objective of this study is to investigate a possible role of the Medial Olivocochlear (MOC) efferent neural pathway and neural connections responsible for tinnitus generation in silence/sensory deprivation. By placing normal hearing participants in a sound booth for 10 minutes, silence/sensory deprivation was created. This offered assessment of MOC neural pathway in normal hearing participants in silence. Hyperactivity of MOC neural pathway was assessed by its more suppressive effect on Transient Otoacoustic Emissions (TEOAEs) in silence. The required auditory measurements were recorded in the sound booth using recommended diagnostic protocols to ensure the effect of 'only silence' on auditory structures. TEOAE were recorded from the right ear and suppression was measured by placing noise in the left ear. Fifty-eight normal hearing male individuals between age 18-35 years were recruited as participants in this study. Approximately, forty-one percent of the participants perceived some type of tinnitus during/after 10 minutes of silence. No statistically significant difference was found in the total TEOAE amplitude and TEOAE suppression amplitude before and after ten minutes of silence. Post silence total TEOAE suppression between tinnitus perceiving and non-perceiving tinnitus participants were not statistically significantly different. These results suggest that the medial olivocochlear efferent pathway or lower brain stem area does not appear to play a role in the emergence of temporary tinnitus in silence however indicate the involvement of higher central auditory nervous system structures in perception of the tinnitus which support the well-accepted notion that tinnitus is the central auditory processing phenomenon.

Nonlinear Behavior of Helmholtz Resonator With a Compliant Wall for Low-Frequency, Broadband Noise Control

Abstract Low-frequency sound attenuation is often pursued using Helmholtz resonators (HRs). The introduction of a compliant wall around the acoustic cavity results in a two degrees-of-freedom (2DOF) system capable of more broadband sound absorption. In this study, we report the amplitude-dependent dynamic response of a compliant-walled HR and investigate the effectiveness of wall compliance to improve the absorption of sound in linear and nonlinear regimes. The acoustic-structure interactions between the conventional HR and the compliant wall result in non-intuitive responses when acted on by nonlinear amplitudes of excitation pressure. This paper formulates and studies a reduced order model to characterize the nonlinear dynamic response of the 2DOF HR with a compliant wall compared to that of a conventional rigid HR. Validated by experimental evidence, the modeling framework facilitates an investigation of strategies to achieve broadband sound attenuation, including by selection of wall material, wall thickness, geometry of the HR, and other parameters readily tuned by system design. The results open up new avenues for the development of efficient acoustic resonators exploiting the deflection of a compliant wall for suppression of extreme noise amplitudes.

Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor

BackgroundResting tremor is one of the most common symptoms of Parkinson’s disease. Despite its high prevalence, resting tremor may not be as effectively treated with dopaminergic medication as other symptoms, and surgical treatments such as deep brain stimulation, which are effective in reducing tremor, have limited availability. Therefore, there is a clinical need for non-invasive interventions in order to provide tremor relief to a larger number of people with Parkinson’s disease. Here, we explore whether peripheral nerve stimulation can modulate resting tremor, and under what circumstances this might lead to tremor suppression.MethodsWe studied 10 people with Parkinson’s disease and rest tremor, to whom we delivered brief electrical pulses non-invasively to the median nerve of the most tremulous hand. Stimulation was phase-locked to limb acceleration in the axis with the biggest tremor-related excursion.ResultsWe demonstrated that rest tremor in the hand could change from one pattern of oscillation to another in space. Median nerve stimulation was able to significantly reduce (− 36%) and amplify (117%) tremor when delivered at a certain phase. When the peripheral manifestation of tremor spontaneously changed, stimulation timing-dependent change in tremor severity could also alter during phase-locked peripheral nerve stimulation.ConclusionsThese results highlight that phase-locked peripheral nerve stimulation has the potential to reduce tremor. However, there can be multiple independent tremor oscillation patterns even within the same limb. Parameters of peripheral stimulation such as stimulation phase may need to be adjusted continuously in order to sustain systematic suppression of tremor amplitude.

A high performance active noise control system for magnetic fields.

We present a system for active noise control of environmental magnetic fields based on a filtered-x least mean squares algorithm. The system consists of a sensor that detects the ambient field noise and an error sensor that measures the signal of interest contaminated with the noise. These signals are fed to an adaptive algorithm that constructs a physical anti-noise signal canceling the local magnetic field noise. The proposed system achieves a maximum of 35 dB root-mean-square noise suppression in the DC-1kHz band and 55 and 50 dB amplitude suppression of 50 and 150Hz AC line noise, respectively, for all three axial directions of the magnetic vector field.