Globally, health information systems have been improved by District Health Information System Version 2 (DHIS2), which promotes consistency and integrity in collecting data, processing, and utilization. This success has been attributed to its user-friendly interface and incorporation of advanced data analysis and validation features. This study aimed to assess DHIS2 data utilization among health professionals working at private hospitals in the Amara region. An Institution-based cross-sectional study design was conducted from 9 May to 30 June 2022. A simple random sampling technique was used to select participants, with a total of 395 health professionals participating. Data was collected using a self-administered paper-based questionnaire. Data entry was performed using the Kobo Collect tool, and data analysis was conducted using STATA version 14.0. Bivariable and multivariable logistic regression analyses were used and p < .05 with a 95% CI was considered to measure statistically significant variables. Out of 395 participants, about 37.72% of the participants had good DHIS2 data utilization. Had good data analysis skills (adjusted odds ratio (AOR) = 6.5, 95% CI [3.1-13.8]), regular supportive supervision and feedback (AOR = 5.2, 95% CI [2.8-9.5]), monthly salary > 5000 ETB (AOR = 2.0, 95% CI [1.1-3.7]), ease of use (AOR = 5.4, 95% CI [2.8-10.2]), and district health information system training (AOR = 4.2, 95% CI [2.2-7.3]) were enabling factors for utilization of DHIS2 data. Private healthcare providers had limited utilization of DHIS2 data. It is highly recommended to provide DHIS2 training, supervision, and feedback focused on private health facilities. Additionally, enhancing data analysis skills and prioritizing ease of use are crucial to improving DHIS2 data utilization.