Superficial Femoral Research Articles

Emerging stent and balloon technologies in the femoropopliteal arteries.

Endovascular procedures for the management of the superficial femoral (SFA) and popliteal artery disease are increasingly common. Over the past decade, several stent technologies have been established which may offer new options for improved clinical outcomes. This paper reviews the current evidence for SFA and popliteal artery angioplasty and stenting, with a focus on randomized trials and registries of nitinol self-expanding stents, drug-eluting stents, dug-coated balloons, and covered stent-grafts. We also highlight the limitations of the currently available data and the future routes in peripheral arterial disease (PAD) stent and balloon technology.

Assessment of lower extremity arterial blood flow in females with knee osteoarthritis

To investigate whether blood flow in the lower extremity arteries changes in patients with osteoarthritis (OA) using color Doppler ultrasonography. The study comprised 39 female patients with osteoarthritis and 30 healthy female controls. The patients were evaluated using visual analogue scale (VAS) at rest and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Color Doppler imaging was used to measure mid-diastolic velocity (MD), pulsatility index (PI), peak systolic velocity (PS), end-diastolic velocity (ED), vascular diameter, and flow volume in the external iliac (EIA), common femoral (CFA), superficial femoral (SFA), deep femoral (DFA), popliteal (PA), anterior tibial (ATA), posterior tibial (PTA), and distal superficial femoral arteries (DSFA). The femoral artery intima-media thickness (FIMT) was also measured. OA patients' PS and flow volume in the EIA and SFA were greater than those of controls, as were PI and ED in the EIA, ED in the PA, MD in the DFA, and the diameter of the PA, ATA, and PTA (p < 0.05). There were no statistically significant differences in FIMT between patients with knee OA and controls (p > 0.05). The flow volume of the main arteries feeding the knee joint is significantly greater than normal in patients with symptomatic knee OA. No evidence was identified relating this difference to ischemic processes.

Conduit Diameter and Wall Remodeling in Elite Athletes and Spinal Cord Injury

This study aimed to investigate localized and systemic effects of chronic exercise and inactivity on conduit artery remodeling in humans. We recruited elite athletes engaged in predominantly lower limb (LL runners/cyclists, n = 10) or upper limb (UL canoe paddlers, n = 12) exercise and matched able-bodied, recreationally active, controls (C, n = 16). We also studied wheelchair controls (spinal cord injury, n = 9) and athletes (spinal cord injury, n = 1; spina bifida, n = 4). Carotid, brachial, and superficial femoral (SF) artery diameter and wall thickness were assessed using high-resolution ultrasound. Brachial diameters were significantly larger in UL and wheelchair users (athletes and controls) compared with C (both P < 0.05). SF artery diameter in wheelchair controls was significantly smaller compared with the other groups, with LL athletes having significantly greater lumen diameter than controls (both P < 0.05). In all arteries, a lower wall thickness was found in able-bodied athletes compared with C, including wheelchair athletes compared with wheelchair controls (P < 0.001). In the SF artery, wall-to-lumen-ratio was significantly lower in able-bodied athletes and higher in wheelchair controls compared with able-bodied controls (P < 0.001). In the brachial and carotid arteries, able-bodied and wheelchair athletes demonstrated lower wall-to-lumen-ratio than less active wheelchair controls and able-bodied controls (P < 0.001). These findings suggest that remodeling of the arterial wall occurs systemically in response to exercise training and is unrelated to exercise type in humans. Conversely, localized effects are evident with respect to the effect of exercise on arterial diameter. These findings have implications for our understanding of the effects of exercise on arterial structure and function in humans.

MISAGO 1: first-in-man clinical trial with Misago™ nitinol stent

To evaluate a newly developed self-expanding Misago (Terumo Corp., Tokyo, Japan) nitinol stent with rapid exchange delivery catheter for the treatment of stenotic or occluded superficial femoral (SF) or popliteal arteries. MISAGO 1 clinical trial enrolled 55 patients undergoing percutaneous intervention of totally occluded or stenotic lesions in SF or popliteal arteries treated with the implantation of 81 stents in five centres across Europe. Primary endpoint was restenosis rate at six months assessed by duplex sonography. Patients (67% male) were 68+/-9 years old, 60% were smokers and 31% had diabetes. Clinical symptoms of ischaemia were present in all patients. Average lesion length was 85+/-50 mm, 64% were totally occluded and 38% classified as TASC C or D. The technical success rate was 100% while the procedural success rate was 98.2% without death, MI, stroke, or major bleeding. At six months follow-up the restenosis rate was 8.5%. One patient (1.8%) died of bronchial carcinoma and two (3.6%) underwent target vessel revascularisation. Mean ankle brachial index improved from 0.70 at baseline to 0.95 at six months while walking capacity on treadmill test improved with an average of 147 m. Rutherford index at six months demonstrated improvement of 72%, without any patients having symptom deterioration. One case of stent fracture was observed. The results from this first-in-man study indicate good safety and short to medium term efficacy profile of the Misago nitinol stent.

Initial feasibility of a multi‐station high resolution three‐dimensional dark blood angiography protocol for the assessment of peripheral arterial disease

To evaluate the feasibility of a multi-station three dimensional (3D) T1-weighted turbo spin echo (TSE) dark-blood Sampling Perfection with Application optimized Contrasts using different flip angle Evolution sequence (T1w-SPACE), to assess aorta, iliac, and superficial femoral (SFA) arteries (inflow vessels) by comparing it with a multi-station contrast enhanced MR angiography (CE-MRA) with identical resolution. A total of 6 volunteers and 14 peripheral arterial disease (PAD) patients were included in the study. Abdominal and thigh T1w-SPACE and lower leg time-resolved MRA (TR-MRA) with low dose contrast were followed by 3-station CE-MRA. Quantitative measurements of lumen area at 17 locations from T1w-SPACE and CE-MRA were obtained. Additionally, vessel wall areas at the same locations were obtained from the T1w-SPACE images. Quantitative comparison of lumen areas with T1w-SPACE and CE-MRA revealed strong correlation between the two techniques and strong inter-observer agreement for each of the two imaging methods (r > 0.9; P < 0.001). Localized vessel wall area measurements obtained in PAD patients were significantly greater compared with those obtained in normal volunteers (mean difference 43.75 +/- 12.46 mm(2); P < 0.001). Stenosis severity obtained from T1w-SPACE localized measurements showed significant arterial area stenosis in PAD patients. T1w-SPACE imaging of inflow vessels is feasible, and in addition to CE-MRA has the ability to assess atherosclerotic plaque and vascular remodeling.

Primary stenting of the superficial femoral and popliteal artery

Over the last decade, the number of endovascular procedures performed on the superficial femoral (SFA) and popliteal arteries (PA) has significantly increased. There is no consensus on the optimal form of intervention used in this arterial segment. While some have advocated balloon angioplasty alone, others have championed either selective or primary stenting of these lesions. It is the purpose of this study to determine the efficacy and durability of primary stenting of the superficial femoral and popliteal artery. All patients undergoing peripheral angioplasty by a single vascular surgeon were prospectively enrolled in an Institutional Review Board-approved, primary-stenting protocol. During a 44-month period, all patients undergoing percutaneous transluminal angioplasty of the SFA or PA also received primary arterial stenting with bare, self-expanding nitinol stents. Patient demographics and risk factors were identified. TransAtlantic InterSociety Consensus (TASC) classifications were determined for all lesions. Loss of primary patency was said to have occurred when an occlusion or a 50% or greater stenosis in any treated arterial segment was diagnosed by arterial duplex or angiography. Only time to loss of primary patency was recorded. Kaplan-Meier survival curves were plotted and differences between groups tested by log rank method. Between January 16, 2004 and August 13, 2007, 201 angioplasties with primary stenting were performed on 161 patients. One hundred twenty-three stents were placed for claudication, and 78 for critical limb ischemia. Forty-six segments treated were TASC A, 82 were TASC B, 38 were TASC C, and 35 were TASC D. Patient follow-up ranged from three to 1329 days (mean: 426 days). Primary patency rates for TASC A and B lesions were 79%, 67%, and 57% at 12, 24, and 36 months. For TASC C and D lesions, primary patency rates were 52.7%, 36%, and 19% at the same time intervals. Primary patency rates for TASC A and B lesions were significantly higher than for C and D lesions (P < .001). The limb salvage rate was 88.5% in patients with critical limb ischemia. Distal runoff did not influence patency (P = .827). Primary stenting of the SFA and PA provides durable results in patients with TASC A and B lesions and may be an effective treatment strategy. This approach is significantly less effective when used in treating those with TASC C and D disease. Based on the results in this series, the use of primary stenting does not extend the anatomic limits of the current treatment recommendations for catheter-based intervention in patients with infrainguinal occlusive disease.

CryoPlasty therapy of the superficial femoral and popliteal arteries: A reappraisal after 44 months' experience

Long-term patency remains a significant hurdle in the minimally invasive treatment of arteriosclerosis in the superficial femoral (SFA) and popliteal arteries. CryoPlasty therapy (PolarCath, Boston Scientific Corp, Natick, Mass) is a novel approach designed to significantly reduce injury, elastic recoil, neointimal hyperplasia, and constrictive remodeling. The technique combines the dilatation forces of percutaneous transluminal angioplasty (PTA) with cold thermal energy applied to the plaque and vessel wall. We previously reported a technical success rate of 96% and a 12-month freedom from restenosis rate of 82.2%. However, a review of the original cohort supplemented by experience with a further 47 lesions has demonstrated less desirable results. From December 2003 through July 2007, 92 lesions in 64 consecutive patients were treated and followed up for a median of 16 months with statistically significant follow-up at 24 months. The immediate technical success rate was 88%. Nine stents were immediately required after unsuccessful CryoPlasty (9.8%) five of which were as a result of a dissection. No unanticipated adverse events occurred, specifically, no thrombus, acute occlusions, distal embolizations, aneurysms, or groin complications. Vascular calcification was responsible for technical failure in six of the 11 immediately unsuccessful procedures. Freedom from restenosis for successfully treated lesions was 57% and 49% at 12 and 24 months, respectively. CryoPlasty of heavily calcified lesions, vein graft lesions, and in-stent stenosis faired poorly. Excluding these lesions from analysis would have resulted in an immediate success of 94% (81 of 86) and freedom from restenosis of 61% and 52% at 12 and 24 months, respectively. However, on an intention-to-treat basis, freedom from restenosis was 47% and 38% at 12 and 24 months, and CryoPlasty added approximately $1700 to the cost of each procedure. Analysis of this expanded, longer-term data suggests that our earlier, smaller study provided an overly optimistic appraisal of the benefits of CryoPlasty. It is possible that a larger analysis might have identified a subset of patients or lesions that would benefit from CryoPlasty, but considering the additional cost, we no longer use this technique in our practice.

Vascular adaptations to 8‐week cycling training in older men

Because age-related changes in the large conduit arteries (increased wall thickness, and attenuated arterial compliance and endothelial function) are associated with cardiovascular pathology, prevention is of paramount importance. The effects of endurance training (i.e. walking or cycling) in older humans are assessed in cross-sectional studies, examining the brachial and carotid arteries (supplying non-trained areas). The purpose of this study was to assess the effects of 8-week endurance training in older men on conduit artery characteristics in the trained and non-trained vascular beds. In eight healthy sedentary older men (70 +/- 3 years), characteristics of the large conduit arteries [common femoral (CFA), superficial femoral (SFA), carotid (CA), and brachial artery (BA)] were measured before and after 8-week cycling training. Functional [arterial compliance and flow-mediated dilation (FMD)] and structural (diameter and intima-media thickness) conduit artery properties were measured using echo-Doppler. Peak blood flow, representing structural peripheral adaptations, was measured using venous occlusion plethysmography. After training, peak leg blood flow was increased (P < 0.01) and baseline diameter and flow were increased in the CFA (P < 0.05). Cycling training enhanced arterial compliance of the SFA (P = 0.03), but did not affect the FMD (P = 0.32) or the intima-media thickness of the SFA. Exercise training did not alter characteristics of the BA or CA. Eight weeks of endurance training in older men altered functional and structural characteristics of the lower extremity vasculature, whereas no changes are reported for the conduit arteries in the non-trained areas (BA or in the CA).

Duplex-Guided Balloon Angioplasty of Lower Extremity Arteries

The conventional balloon angioplasty of infrainguinal arteries requires the use of fluoroscopy and injection of contrast material. We attempted to perform 360 balloon angioplasties of the superficial femoral (SFA) and/or popliteal arteries under duplex guidance in 274 patients to avoid the nephrotoxic effect of contrast and eliminate or minimize radiation exposure. Critical ischemia was the indication in 35% of cases and severe claudication in 65%. Infrapopliteal angioplasties of 80 arteries were attempted in 54 cases (15% of all cases) in order to improve the run-off after completion of femoral-popliteal angioplasties. For femoral-popliteal segment, overall technical success was 95% (342/360 cases). For infrapopliteal arteries, technical success was achieved in 77 of 80 cases, with an overall success rate of 96%. Twelve-month patency rates for TASC class A, B, C, and D lesions were 90%, 59%, 52%, and 46%, respectively. PAVF <100 mL/min was the most powerful predictor of 30-day and 6-month arterial thrombosis following femoral/popliteal balloon angioplasties.Duplex-guided balloon angioplasty and stent placement appears to be a safe and effective technique for the treatment of femoral-popliteal and infrapopliteal arterial occlusive disease. PAVF <100 mL/min is the most powerful predictor of early (30 days) and midterm (6-month) arterial thrombosis following femoral-popliteal interventions.

The Results of Superficial Femoral, Popliteal, and Tibial Artery Stenting for Peripheral Vascular Occlusive Disease

The purpose of this study was to evaluate the patentcy rates and physiological effectiveness of angioplasty and stenting as a primary therapy for superficial femoral (SFA), popliteal (POP), and tibial (TIB) arterial occlusive disease. Seventy-eight patients had stents placed in the infra-inguinal vessels between January 1, 2001, and July 31, 2004. We collected data on patient demographics, symptoms, as well as pre- and postprocedure ankle-brachial index (ABI) and angiographic findings. Patency rates at 6 months, 12 months, and 24 months were analyzed by life table methods. Thirty-one men and 47 women had a mean age of 68 years (range 36-94 years). Risk factors included diabetes in 50 per cent, hypertension in 79 per cent, smoking in 41 per cent, and end-stage renal disease in 10 per cent. The indications for intervention were claudication in 52 per cent and limb salvage in 48 per cent of patients. Stents were placed in the SFA in 54 patients (69%), in the POP in 15 patients (18%), and in the TIB artery in 6 patients (8%). Average follow-up was 11.2 months. The mean postprocedural increase in ABI was 0.29. The 6-month, 1-year, and 2-year primary patency rates were 83 per cent, 58 per cent, and 47 per cent, respectively. Limb salvage was achieved in 66 per cent of patients treated for limb-threatening ischemia. There was one major and three minor complications. Stenting of the infra-inguinal vessels has a low morbidity, high success rate, and acceptable patency and limb-salvage rates.

Lower extremity volumetric arterial blood flow in normal subjects

The objective of this clinical study was to establish normal values for volumetric blood flow in the leg at rest using Doppler ultrasound, and to determine what biophysical factors influence resting volumetric flow. Arterial blood flow was measured at four sites in the legs of 40 healthy subjects using an ATL Ultramark 9 HDI® system. All subjects were nonhypertensive nonsmokers with ankle brachial index values greater than 1 and no history of vascular disease. The subjects, 20 of each gender, in age ranging from 20 to 64 y were examined. Blood flow was calculated from the time-averaged, intensity-weighted mean velocity Doppler waveforms and vessel cross-sectional area at the same site. Thigh and calf circumference measurements were used to estimate muscle masses. The mean flow and standard error measured in four arteries in the leg were: 284 ± 21 mL/min in the common femoral (CFA); 152 ± 10 mL/min in the superficial femoral (SFA); 72 ± 5 mL/min in the popliteal; and 3 ± 1 mL/min in the dorsalis pedis. Although women tended to have higher time-averaged mean velocities in the CFA and SFA than men ( t-test, p < 0.008), their arterial cross-sectional areas tended to be smaller ( t-test, p < 0.004) and no statistically significant difference was found between men and women in volumetric flow at any site. No correlation was found between age, weight, height, muscle mass and volumetric flow at all four sites. These estimates of lower extremity volumetric flow in healthy subjects provide a baseline for future studies of flow rates in patients with vascular disease.

Lower extremity arterial evaluation: Are segmental arterial blood pressures worthwhile?

Purpose: Physiologic observations with blood flow waveform analysis and pressure measurements can document the severity of lower extremity arterial disease. Segmental blood pressures (SEGPs) taken at the thigh, calf, and ankle are commonly used, but their utility has seldom been studied. We quantified improvements in accuracy compared with arteriography when ankle pressures alone (ABI) or SEGP data were added to velocity waveforms obtained by Doppler ultrasound. Methods: Continuous-wave Doppler velocity waveforms were recorded at common femoral (CFA), popliteal (POP), and dorsal pedal and posterior tibial (TIB) arterial levels. Systolic SEGP data were obtained with appropriately sized upper thigh, upper calf, and ankle cuffs. Waveforms, waveforms plus ABI, and waveforms plus SEGP data from 81 patients were randomly interpreted by 14 technologists or physicians from four institutions blinded to clinical and arteriographic data. Arteriograms were assigned negative or significant, severe (≥75% diameter stenosis) values for four segments: iliofemoral (CFA), superficial femoral (SFA), popliteal (POP), and infrapopliteal (TIB) arteries. A total of 9072 segmental interpretations were analyzed. Results: Compared with arteriography, the accuracy of waveform analysis was 83% for severe disease at and proximal to the CFA, 79% for SFA disease, 64% for POP disease, and 73% for TIB disease. Adding ABI improved the accuracy significantly ( p < 0.01) to 88% (CFA), 86% (SFA), 70% (POP), and 85% (TIB). Accuracy was inferior when SEGP data replaced ABI: 86% (CFA), 85% (SFA), 70% (POP), and 80% (TIB). Conclusions: ABIs significantly improved Doppler waveform accuracy at all levels. Compared with ABI, the addition of segmental pressure to waveform data failed to improve accuracy. Pressure measurements above the ankle may lack cost effectiveness and clinical utility. (J Vasc Surg 1998;27:831-9.)

Observer variability in volumetric blood flow measurements in leg arteries using duplex ultrasound

Duplex ultrasound volumetric flow measurements have not found a major clinical use because of variability caused by errors in estimating cross-sectional area (CSA) and in measuring time averaged mean velocity (TAMeV). We determined inter- and intraobserver variation in volumetric blood flow measured at rest in the common femoral artery (CFA) and its main branches, the superficial femoral (SFA) and profunda femoris (PFA) arteries, in 20 normal subjects. The product of TAMeV and CSA was taken as volumetric flow. The coefficient of variation of TAMeV was consistently greater than that of CSA. Interobserver variation for blood flow (16.2%, 20.2% and 40.3% for CFA, SFA and PFA, respectively) was larger than intraobserver variation (13.0%, 15.1%, 21.2%). In conclusion, these data define the minimum changes in VQ that can be realistically detected and indicate that, with modern duplex Doppler equipment, volumetric flow can be used as a reliable haemodynamic measure for monitoring patients before and after surgical or radiological intervention.

Progression of atherosclerosis in arteries distal to lower extremity revascularizations

The characteristics of progression of atherosclerotic occlusive disease (AOD) of the lower extremities after revascularization are unknown. Duplex scanning or angiography were used to determine progression in 150 patients after they underwent revascularization for AOD. Follow-up studies were compared with presurgical arteriograms. Superficial femoral (SFA) and popliteal arteries were graded as less than 50% stenosis, 50% to 99% stenosis, or occluded. Tibial arteries were graded with regard to whether they were continuously patent from the popliteal trifurcation to the ankle. Progression was defined as an increase in one stenosis category. At a mean follow-up of 4.8 years, 18% of native arteries, 39% of extremities, and 52% of patients demonstrated progression of AOD. Overall, 21% of arteries in patients undergoing infrainguinal bypass and 14% of arteries in patients undergoing suprainguinal bypass demonstrated progression (p = 0.004). Progression was more frequently detected in examinations performed more than 4 years after baseline arteriography (66%) than in examinations performed 6 months to 2 years (45%, p = 0.032) or 2 to 4 years (44%, p = 0.029) after baseline arteriography. Thirty percent of SFAs demonstrated progression, and 32% with 50% stenosis or greater at baseline became occluded. There was no difference in SFA, popliteal, or tibial artery progression in revascularized versus nonrevascularized extremities after suprainguinal bypass. There was no difference in tibial artery progression in operated and nonoperated limbs after femoropopliteal artery bypass. AOD progression occurs frequently in patients requiring revascularization and is more prevalent in patients requiring femoropopliteal than in patients requiring suprainguinal bypass. AOD progression in patients undergoing vascular surgery is associated with the pattern of disease producing lower extremity ischemia and does not appear to be worsened by arterial reconstruction.

In vitro experiment and initial clinical experience in angioplasty, in vascular occlusive disease with a new pulsed dye-laser system

The feasibility of using a pulsed dye-laser in angioplasty for detection and disintegration of calcified plaques was studied in vitro. The laser (495 nm wave-length; 2 μs pulse duration) was used as the exciting source for laser-induced-fluorescence (LIF) signals. Spectral data in the 520 to 800 nm region of normal artery wall, calcified plaques, and fibro-fatty plaques were analysed with an optical multichannel analyser. Good signal-to-noise ratio and different spectra for different specimens were obtained within only 2 μs. Fluorescence analysis can be performed in less than 300 ns and therefore the laser can be controlled before plasma threshold is reached. This can lead to a clinical by useful feedback system in an “intelligent” laser, which can selectively ablate atherosclerotic tissue. In a parallel step we investigated a pulsed dye-laser device (504 nm; 1.2 μs) for in vivo recanalisation of arteries in ischaemic lower limbs. A specially designed 9F or 7F guide wire directed multifibre catheter was used for treatment of 17 patients. The recanalisation technical success was 8/8 (4 occlusions/5 stenoses) in the iliac arteries (IA) and 8/9 (8 occlusions/4 stenoses) in the superficial femoral (SFA) and popliteal arteries (PA). All occlusion lengths were below 10 cm. Three early re-occlusions occured, caused by very bad run-off. There was one clinically insignificant SFA perforation and one groin haematoma. Additional techniques (balloon dilatation, stenting, lysis) were considered necessary in 15/17 patients. Mean ankle-arm-index increased significantly in the 1 week examination in rest from 0.61 to 0.76 (P < 0.05) in IA and from 0.65 to 0.93 (P < 0.01) in SFA. Pulsed dye-laser angioplasty promises to be an effective method for plaque ablation/debulking.

Color Doppler imaging of infrainguinal arterial occlusive disease

Few reports in the literature validate the use of color Doppler imaging (CDI) for the evaluation of lower extremity arterial occlusive disease, particularly in the tibial and peroneal arteries. This prospective, blinded study compares CDI to arteriography to address the following questions: (1) how well does CDI visualize arterial segments, including those below the knee? and (2) can CDI alone accurately classify the degree of occlusive disease? Twenty-nine men undergoing arteriography before a lower extremity arterial reconstructive procedure were studied with a color ultrasound scanner from the level of the inguinal ligament to the ankle. Color images were examined for the presence or absence of triphasic flow, poststenotic turbulence, color bruits, and collateral vessels. Among 636 arterial segments adequately visualized by arteriography, ≥ 90% were identified with color Doppler imaging, including the tibial and peroneal arteries. With color criteria only, specificity was ≥ 92% for distinguishing < 50% from ≥ 50% lesions and ≥ 93% for differentiating patent from occluded arteries. Sensitivity for detecting an occlusion was ≥ 97% in the superficial femoral (SFA) and popliteal arteries and 83% in the tibial vessels. For identifying a ≥ 50% stenosis, sensitivity was ≥ 85% in the SFA and popliteal arteries but only 79% and 86% in the posterior and anterior tibial arteries, respectively. CDI reliably identifies vessel location from the level of the groin to the ankle. For the detection of occlusions, CDI is an accurate screening tool in the SFA and popliteal arteries but is less accurate in the tibial vessels. Furthermore, given the modest sensitivity of CDI for identifying ≥ 50% stenoses, we do not recommend the use of color criteria alone to rule out the presence of a high-grade lesion. CDI is a valuable adjunct to duplex ultrasonography but should not be used as a substitute for a careful Doppler examination with spectral waveform analysis.

Role of superficial femoral artery puncture in the development of pseudoaneurysm and arteriovenous fistula complicating percutaneous transfemoral cardiac catheterization.

Of 13,203 transfemoral diagnostic and therapeutic cardiac catheterization procedures performed between January 1, 1980 and December 31, 1990, 73 (0.55%) were complicated by pseudoaneurysm (PA) formation, and 15 (0.11%) by arteriovenous fistulas (AVF). The rate of PA increased progressively from 0.44% (1980-1987), to 0.59% (1987-1989), to 0.92% (1990), with no corresponding change in the incidence of AVF. The rising incidence of PA complicating transfemoral cardiac catheterization was associated closely with the use of larger diameter catheters and aggressive antiocoagulation during coronary interventions, but findings during surgical repair suggested that puncture of the superficial femoral (SFA), rather than the common femoral artery (CFA), was an important avoidable cause of some PA and AVF. A technique for fluoroscopic localization of the puncture site to avoid inadvertent SFA puncture and the associated increased risk of complication is proposed.

Pulsed doppler assessment of normal human femoral artery velocity patterns

Duplex scanning permits simultaneous B-mode imaging of arteries and pulsed Doppler assessment of center stream velocity patterns. By using spectrum analysis to quantitate the frequency distribution of the reflected Doppler signal and the B-mode image to measure the Doppler angle, instantaneous flow velocity can be calculated from the Doppler equation. Resting common femoral (CFA), superficial femoral (SFA), and profunda femoris artery (PFA) maximum center stream velocity, both forward and reverse, as well as the maximum velocity response of the CFA to reactive hyperemia induced by 3 min of cuff occlusion, was calculated bilaterally in ten healthy young subjects without evidence of arterial disease. Mean forward and reverse velocities in the CFA (69.73 cm/sec ± 3.96 (SEM) and 27.51 cm/sec ± 1.56 (SEM), respectively) and SFA (70.26 cm/sec ± 3.38 (SEM) and 26.76 cm/sec ± 1.69 (SEM), respectively) were similar; however, both of these parameters were lower in the PFA (51.74 ± 2.95 (SEM) and 14.92 ± 1.09 (SEM), respectively, P < 0.001). Furthermore, the relative magnitude of the reverse velocity component in the PFA was less than in the CFA or SFA, as indicated by a lower ratio of reverse to forward velocity ( P < 0.02). Reactive hyperemia induced an increase in forward velocity in all CFAs which averaged 49.4%. Spectral evidence of transient flow disturbances was noted and the reverse component disappeared in all of these vessels for an average of 22 sec. A discussion of previous work in this field and of the possible relationship of these findings to arterial disease is presented.