The frame-core tube hybrid structure is an important high-rise building structure system which is widely used in the world at present. The stiffness ratio of frame to core tube affects the dynamic characteristics of the structure. In this paper, nine models of concrete-filled steel tubular frame-concrete core tube super high-rise hybrid structure with different stiffness ratios are analyzed by subspace iteration method, and the analysis of the acceleration and displacement response spectrum value of each vibration mode under frequent earthquakes are carried out. The results show that the stiffness ratio has different effects on different modes, the fundamental frequency, natural period, acceleration and displacement response of the structure of the first mode increase with the stiffness ratio increasing, and it is feasible and significant to interpret the seismic response of structures from studying the dynamic characteristics of seismic waves and structures.