Results are given in the present paper of work establishing a link between structure and insecticidal activity in a series of varied nitrogen-, sulfur-, and phosphorus-containing compounds based on the systematic physicochemical approach developed by us in [i, 2]. The whole group of i00 substances investigated contained compounds synthesized in the Institute of the Physioiogy ofActive Substances(-IFAV)~Institute0f Organic Chemistry (lOKh), and the Institute of Heteroorganic Compounds (INEOS) of the Academy of Sciences of the USSR (AN SSSR). They were tested by a single method for the activity indicated in the All-Union Scientific-Research Institute of Agriculture and Plant Protection (VNIIKhSZR). Insecticidal preparations used in agriculture, viz. metaphos, estaphos, and cidial, were included in the group. The selection comprised 44 phosphorus-containing compounds, 16 sulfur-containing pyridine derivatives, and also compounds containing phenyl, amide, carbonyl, NH-N=C or C=N groups.