Choosing adequate topical antimicrobial agents in burn patientsstill representsa challenge.Therefore, thissystematic review was conducted tocompile and evaluatecurrent recommendations in international clinical practice guidelines (CPGs) to develop more consistent clinicalguidance. A systematicsearchfor CPGswas conducted independently by two reviewers using PubMed, EMBASE, Google Scholar, and external citations. The quality of theselectedCPGswas evaluatedseparatelyusing the AGREE II instrument, and intraclass correlation coefficients were calculated. Statistical analysis was performed using R V 1.4.1 statistical software. Eleven CPGs were included in the study.Most guidelines tend to recommendsilver-containingdressings over antiseptics or antibiotics,regardless of the depth of the burn.Silver sulfadiazine is the most recommended topical antimicrobial in low-resource settings.An overall mean appraisal AGREE II score of 68.2% wasobtained. The global intraclass correlation coefficient was 0.62 (95% confidence intervals 0.54-0.69), which corresponds to a substantial global concordance between both appraisers. Greatheterogeneity was found between recommendationsand CPGs. The three determining factors considered to issue a recommendation were the clinical scenario, burn-wound depth, and burn severity. There is consensus among the guidelines to use topical antimicrobials as a tool to prevent infection, and most of these recommend the use of silver-containing dressings for most scenarios. However, there is currently no ideal topical antimicrobial agent that can be recommended for all clinical scenarios.The development ofmoreconsistent recommendations iswarrantedto standardizeclinicalpractice.