Formulation Design and Characterization of Silver Sulfadiazine Loaded Nano Gel in the Treatment of Burn

Abstract

Background: In permeation of drug, size of drug plays a very important role as size of dug as much as smaller, it become very easy to permeate so that researchers attract towards making size in nano range. Silver sulfadiazine on of the drug which is very useful in the treatment of burn. Many processes are adapted to make nanoparticles of this drug but the promising method of preparation of NPs of this drug is still vacant. Objectives: Development of silver sulfadiazine loaded Nano gel by using Noveon polycarbophil AA-1 as gelling agent in the treatment of burn infections. Method: First of all, nanoparticle of silver sulfadiazine was prepared by Modification Emulsification method. Then a gel was prepared by using Noveon polycarbophil AA-1 as gelling agent and varying homogenization time. Prepared formulations were subjected to evaluation accordance with standard Nano gel. Result: The formulation of Nano gel of silver sulfadiazine was prepared successfully and evaluation data were found at satisfactory level. In order to obtain particle size in Nano range, Noveon polycarbophil AA-1 was used for modification emulsification method in which at 0.75% concentration found to bring Nano size of particle in the range 10 to 200 nm. Formulation was evaluated for % drug entrapment efficiency, cumulative % drug release, spreadability, homogeneity. pH, clarity of gel etc. All the results were found in limit and showed satisfactory level of formulation for FG-5. Conclusion: Silver sulfadiazine loaded Nano gel by using Noveon polycarbophil AA-1 by modification emulsification method and optimum homogenization time would be very promising approach and convenient economically. Keywords: Silver sulfadiazine, loaded, nanogel, burn, Noveon polycarbophil AA-1.