Suitable Matrices Research Articles

Cis-1,3,4,6-Tetranitrooctahydroimidazo-[4,5-d]imidazole (BCHMX) as a part of explosive mixtures

Abstract cis-1,3,4,6-Tetranitrooctahydroimidazo-[4,5-d]imidazole (BCHMX) is a relatively available bicyclic nitramine in the present. Due to the high energetic content of its molecule (deformation of valence angles) it has heat of formation higher than β−1,3,5,7-tetranitro-1,3,5,7-tetrazocane (β−HMX) by nearly three times. As a result, it has heat of explosion and relative explosive strength exceed that of β−HMX including their corresponding PBXs. However, penetration abilities of PBXs based on HMX are higher than those based on BCHMX. The relatively high initiation reactivity of BCHMX could be modified in a wide range by its incorporation in a suitable polymeric matrices. Regarding to the performance, coating of BCHMX crystals by 5 wt% Viton A produces the maximum performance while the mixture of BCHMX with polydimethylsiloxane (PDMS) seems to be the optimum composition for the development of PBX with low sensitivity.

Entrepreneurial dynamics over space and time

Entrepreneurship is a regional and persistent phenomenon. We jointly investigate spatial dependence and serial dynamics of new business formation. Using panel data from all 402 German counties for 1996–2011, we estimate dynamic spatial panel data models of start-up activity in the high-tech and manufacturing industries. We consider regions of different sizes and systematically search for the most suitable spatial weights matrices. We find substantial spatial dependence as well as time persistence of start-up activity, especially in the high-tech industry. This suggests that local start-up activity has positive external effects and that entrepreneurship policy could play an efficiency-enhancing role.

Toward Semistructural Cellulose Nanocomposites: The Need for Scalable Processing and Interface Tailoring

Cellulose nanocomposites can be considered for semistructural load-bearing applications where modulus and strength requirements exceed 10 GPa and 100 MPa, respectively. Such properties are higher than for most neat polymers but typical for molded short glass fiber composites. The research challenge for polymer matrix biocomposites is to develop processing concepts that allow high cellulose nanofibril (CNF) content, nanostructural control in the form of well-dispersed CNF, the use of suitable polymer matrices, as well as molecular scale interface tailoring to address moisture effects. From a practical point of view, the processing concept needs to be scalable so that large-scale industrial processing is feasible. The vast majority of cellulose nanocomposite studies elaborate on materials with low nanocellulose content. An important reason is the challenge to prevent CNF agglomeration at high CNF content. Research activities are therefore needed on concepts with the potential for rapid processing with controlled nanostructure, including well-dispersed fibrils at high CNF content so that favorable properties are obtained. This perspective discusses processing strategies, agglomeration problems, opportunities, and effects from interface tailoring. Specifically, preformed CNF mats can be used to design nanostructured biocomposites with high CNF content. Because very few composite materials combine functional and structural properties, CNF materials are an exception in this sense. The suggested processing concept could include functional components (inorganic clays, carbon nanotubes, magnetic nanoparticles, among others). In functional three-phase systems, CNF networks are combined with functional components (nanoparticles or fibril coatings) together with a ductile polymer matrix. Such materials can have functional properties (optical, magnetic, electric, etc.) in combination with mechanical performance, and the comparably low cost of nanocellulose may facilitate the use of large nanocomposite structures in industrial applications.

N-dimensional extension of unfold-PCA for granular systems monitoring

This work is focused on the data based modelling and monitoring of a family of modular systems that have multiple replicated structures with the same nominal variables and show temporal behaviour with certain periodicity. These characteristics are present in many systems in numerous fields such as the construction or energy sector or in industry. The challenge for these systems is to be able to exploit the redundancy in both time and the physical structure.In this paper the authors present a method for representing such granular systems using N-dimensional data arrays which are then transformed into the suitable 2-dimensional matrices required to perform statistical processing. Here, the focus is on pre-processing data using a non-unique folding–unfolding algorithm in a way that allows for different statistical models to be built in accordance with the monitoring requirements selected. Principal Component Analysis (PCA) is assumed as the underlying principle to carry out the monitoring. Thus, the method extends the Unfold Principal Component Analysis (Unfold-PCA or Multiway PCA), applied to 3D arrays, to deal with N-dimensional matrices. However, this method is general enough to be applied in other multivariate monitoring strategies.Two of examples in the area of energy efficiency illustrate the application of the method for modelling. Both examples illustrate how when a unique data-set folded and unfolded in different ways, it offers different modelling capabilities. Moreover, one of the examples is extended to exploit real data. In this case, real data collected over a two-year period from a multi-housing social-building located in down town Barcelona (Catalonia) has been used.

Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays.

Analytical evaluation of high-sensitivity cardiac troponin (hs-cTn) assays, with particular attention to imprecision, interferences and matrix effects, at normal cTn concentrations, is of utmost importance as many different clinical algorithms use concentration cutoffs <10 ng/L for decision-making. The objective for the present analytical study was to compare the new Beckman Coulter hs-cTnI assay (Access hsTnI) to Abbott's hs-cTnI assay in different matrices and for different interferences, with a focus on concentrations <10 ng/L. The limit of blank (LoB) and the limit of detection (LoD) were determined in different matrices for the Beckman hs-cTnI assay. Passing-Bablok regression and difference plots were determined for 200 matched lithium heparin and EDTA plasma samples for the Beckman assay and 200 lithium heparin samples for the Abbott assay. Both EDTA and heparin plasma samples were also evaluated for stability under refrigerated conditions, for endogenous alkaline phosphatase interference and for hemolysis and icterus. The Beckman hs-cTnI assay LoB was 0.5 ng/L with the following range of LoDs=0.8-1.2 ng/L, with EDTA plasma yielding lower concentrations as compared to lithium heparin plasma (mean difference=-14.9%; 95% CI=-16.9 to 12.9). Below 10 ng/L, lithium heparin cTnI results from the Beckman assay were on average 1.1 ng/L (95% CI=0.7 to 1.5) higher than the Abbott results, with no difference between the methods when using EDTA plasma (mean difference =-0.1 ng/L; 95% CI=-0.3 to 0.2). Low cTnI concentrations were less effected by interferences in EDTA plasma. The Access hsTnI method can reliably detect normal cTnI concentrations with both lithium heparin and EDTA plasma being suitable matrices.

Calixarenes as High Temperature Matrices for Thermally Activated Delayed Fluorescence: C70 in Dihomooxacalix[4]arene.

Thermally activated delayed fluorescence (TADF) of 12C70 and 13C70 was observed up to 140 °C in a p-tert-butyldihomooxacalix[4]arene solid matrix, a temperature range significantly higher than that of previous TADF quantitative studies. An effective singlet–triplet energy gap of 29 kJ/mol and triplet formation quantum yields of 0.97 and 0.99 were measured for 12C70 and 13C70, respectively. The photophysical properties of the two fullerenes in this new matrix are comparable to those obtained in polystyrene at a lower temperature range. Calixarenes are proposed to be suitable matrices for high temperature TADF studies and applications.

Distribution and ecological risks of polycyclic aromatic hydrocarbons (PAHs) in sediments of different tropical water ecosystems in Niger Delta, Nigeria

Sediments are considered as suitable matrices to study the contamination levels of aquatic environment since they represent a sink for multiple contaminant sources. In this study, the influence of sediment characteristics on the distribution of polycyclic aromatic hydrocarbons (PAHs) and its potential risk in euryhaline, freshwater and humic aquatic bodies of Douglas/Stubbs creek, Ikpa River and Eniong River, respectively, were investigated. The level of PAHs in sediment was quantified using GC–MS, while sediment properties including total organic carbon (TOC) content and grain size were determined by the wet oxidation and hydrometer methods, respectively. The results revealed that the total levels of PAHs in sediment varied significantly between the euryhaline, freshwater and humic freshwater ecosystems. In Ikpa River freshwater ecosystem, a total PAHs load of 1055.2 ng/g was recorded with the suites concentration ranging from 13.0 ng/g (for acenaphthylene) to 161 ng/g (for pyrene). The humic ecosystem of Eniong River had a total PAH load of 11.06 ng/g, while the suites level recorded ranged from 0.04 ng/g for acenaphthene to 2.65 ng/g for chrysene. The total level of PAHs detected in the euryhaline Douglas/Stubbs creek was 14.47 ng/g, and suite concentrations varied between 4.27 ng/g for naphthalene and 5.13 ng/g for acenaphthylene. This shows variation in quantity and quality of PAH contaminants with the nature of ecosystems. It implies complex and diverse contamination sources as well as different capabilities to recover from PAH contamination. Correlation analysis has shown that sediment particle and TOC content influenced PAHs burden in bottom sediments, but the effects varied with the molecular weight of PAHs and the nature of the ecosystems. The TOC was the most significant determinant of PAHs load and distribution in sediment of the freshwater Ikpa River and euryhaline Douglas/Stubbs but had little or no influence in the humic sediment of Eniong River, while the influence of particle size was generally indefinite but slightly associated with PAHs accumulation in the euryhaline sediment. Generally, the total PAH levels (11.0–1055.2 ng/g) recorded were low and below the allowable limit for aquatic sediments. The ecological risk assessment revealed that these levels were lower than the effects range low and effects range medium values. This indicates no acute adverse biological effect although the accumulation of PAHs in freshwater ecosystem of Ikpa River may pose ecological risks as most of the carcinogenic PAH suites had relatively high pollution indices compared to other ecosystem types studied.

Biota monitoring under the Water Framework Directive: On tissue choice and fish species selection.

The study addresses the topic of suitable matrices for chemical analysis in fish monitoring and discusses the effects of data normalization in the context of the European Water Framework Directive (WFD). Differences between species are considered by comparing three frequently monitored species of different trophic levels, i.e., chub (Squalius cephalus, n = 28), (bream, Abramis brama, n = 11), and perch (Perca fluviatilis, n=19) sampled in the German Danube. The WFD priority substances dioxins, furans and dioxin-like polychlorinated biphenyls (PCDD/F+dl-PCB), polybrominated diphenyl ethers (PBDE), α-hexabromocyclododecane (α-HBCDD), hexachlorobenzene (HCB), mercury (Hg), and perfluorooctane sulfonic acid (PFOS) as well as non-dioxin-like (ndl)-PCB were analyzed separately in fillet and carcass and whole body concentrations were calculated. Hg was analyzed in individual fish fillets and carcasses, all other substances were determined in pool samples, which were compiled on the basis of fish size (3 chub pools, 1 bream pool, 2 perch pools). The data were normalized to 5% lipid weight (or 26% dry mass in the case of Hg and PFOS) for comparison between matrices and species. Hg concentrations were generally higher in fillet than in whole fish (mean whole fish-to-fillet ratio: 0.7) whereas all other substances were mostly higher in whole fish. In the case of lipophilic substances these differences leveled after lipid normalization. Significant correlations (p ≤ .05) were detected between Hg and fish weight and age. Hg concentrations varied least among younger fish. PCDD/F, dl-PCB, ndl-PCB, PBDE, α-HBCDD and HCB correlated significantly (p ≤ .05) with lipid concentrations. Fillet-to-whole fish conversion equations and/or conversion factors were derived for all substances except α-HCBDD. Although more data also for individual fish would be desirable the results are nevertheless a step on the way to translate fillet concentrations of priority substances to whole fish concentrations.

A novel screening method to identify air pollution by genotoxic compounds.

Genotoxic compounds, as common contaminants of the air environment, are of interest in air pollution monitoring. There are several methods to determine the level of these contaminants in different localities, many of which may be difficult to access with the use of conventional active and passive samplers. In the present study, the needles Pinus mugo Turra and Picea abies were used to monitor sampling localities in Austria, Slovakia, and the Czech Republic. Needles were extracted and chemical analysis and the genotoxicity bioassay SOS chromotest were used to obtain complex information about the chemical mixture of pollutants present and their genotoxic effects. The SOS chromotest method was optimized by using a CPRG chromogenic substrate to reduce the false positive genotoxic effect of needle extracts. Pinus mugo Turra and Picea abies were identified as suitable passive sampling matrices for long-term air monitoring using the same plants sampled at the same time. The presented study brings an innovative method for the fast screening and identification of localities loaded by genotoxic active air contaminants.

Potential application of immobilized streptokinase extracted from Streptococcus equinus VIT_VB2

ABSTRACTStreptokinase purified from Streptococcus equinus VIT_VB2 isolated from bovine milk sample was immobilized in various solid supports namely entrapment in agarose gel, calcium alginate beads and gelatin gel by cross-linking with formaldehyde. Immobilization of streptokinase in calcium alginate beads showed maximum efficiency (81.8 ± 1.06%) when compared with entrapment with agarose gel (55.6 ± 2.17%) and cross-linked gelatin formaldehyde gel (71.0 ± 1.54%). The purified SK activity was expressed maximum in calcium alginate (1%) and gelatin gel (0.25%) with 1292.68 ± 1.33 and 1121.9 ± 1.2 U mL−1, respectively. Similarly, SK entrapped in gelatin gel and calcium alginate showed maximum in vitro blood clot lysis activity with 77.67 ± 2.64% and 76.16 ± 2.72%, respectively. The immobilized SK in gelatin gel showed complete clot lysis within 15 min; hence, this application of the study could be used in the treatment of superficial thrombophlebitis, phlebitis, and venous thrombosis. These beads were used for three repeated cycles to check the conversion of substrates into their products, and we concluded that SK can be immobilized in the suitable matrices. Therefore, this helps in the drug-delivery strategies in highly efficient way, moreover, economically competent process in the pharmaceutics.

Study of imperfect bonding effects on sound transmission loss through functionally graded laminated sandwich cylindrical shells

Effects of imperfect bonding on sound transmission across a double-walled cylinder with FGM-core are studied by using the three-dimensional theory of elasticity. Aluminum and zirconia are inner and outer shells respectively, whereas the FGM-core is sandwiched between these layers. A very thin adhesive epoxy interlayer was applied in order to bond the adjacent layers. The imperfect bonding (adhesive epoxy interlayer) is modeled by a linear spring model. Infinite values of stiffness of linear spring reveal that there are no interfaces between the adjacent layers. However, the interface tractions do not exist and the layers are completely deboned from each other due to zero values of these parameters. The linear spring model is incorporated into the global transfer matrix with the aid of suitable transfer matrices. The proposed model is used to calculate the effects of imperfect bonding on TL of multi-layered cylinder which excited by an external plane wave. The obtained results are compared with those of other researches recently published in the literature. Excellent agreement is observed for high stiffness of adhesive bond. The results have also illustrated the fact that the existence of imperfect interfaces leads to the enhancement of the TL of sandwich cylindrical shell. Moreover, low stiffness of interlaminar adhesive bonding has more positive effect on the TL enhancement, particularly in high frequency range. Finally, it can be concluded that at high frequencies the spring layer model with low stiffness cannot transmit the waves because of more fluctuations.

A Brief Review on Sustained Release Matrix Type Drug Delivery System

Purpose : A review on sustained release drug delivery using polymer matrix with emphasis on its contemporary usage and future trends. Approach : An introduction to sustained release drug delivery system (SR DDS), followed by its rationale, advantages, disadvantages, criteria of a drug to be met to formulate sustained release formulations, classification of matrix tablets, classification of polymers, its mechanism and recent advancements. Finding : Recent studies indicate that sustained delivery for a very long period, in terms of months is possible using suitable polymer matrices. Also, challenging drug candidates such as proteins are now successfully delivered as sustained release dosage forms. Conclusion : Sustained release DDS, since 1940s has evolved in different types of dosage forms for sustained effect but future scope will be to treat chronic diseases providing sustained effect.

Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

N-acyl homoserine lactones (AHL) are small signal molecules involved in the quorum sensing of many gram-negative bacteria, and play an important role in biofilm formation and pathogenesis. Present analytical methods for identification and quantification of AHL require time-consuming sample preparation steps and are hampered by the lack of appropriate standards. By aiming at a fast and straightforward method for AHL analytics, we investigated the applicability of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Suitable MALDI matrices, including crystalline and ionic liquid matrices, were tested and the fragmentation of different AHL in collision-induced dissociation MS/MS was studied, providing information about characteristic marker fragments ions. Employing small-scale synthesis protocols, we established a versatile and cost-efficient procedure for fast generation of isotope-labeled AHL standards, which can be used without extensive purification and yielded accurate standard curves. Quantitative analysis was possible in the low pico-molar range, with lower limits of quantification reaching from 1 to 5 pmol for different AHL. The developed methodology was successfully applied in a quantitative MALDI MS analysis of low-volume culture supernatants of Pseudomonas aeruginosa. Graphical abstract ᅟ.

Temporal evolution of the environmental quality of the Vallona Lagoon (Northern Mediterranean, Adriatic Sea)

Guidance Document 25/2010, suggests sediment and biota are the most suitable matrices for the trend monitoring purpose, because they integrate the pollution over time and space. So, from 2005 to 2014, the sediment and biota concentrations of heavy metals (As, Cd, Cr, Hg, Ni, Pb) were analysed in the Vallona Lagoon (northern Adriatic Sea, Italy), widely used for intensive and extensive bivalve farming. The contamination levels in sediment and biota were compared with Environmental Quality Standard (EQS) and threshold levels (TL) for human health.The results identified critical issues related to Cd in sediment samples as well as to Hg and Pb in biota which were not only ascribable to the physiological and seasonal variability of organisms. The Cr and Ni levels in sediment were higher than the EQS. However, the concentration increases at biota stations close to sites where EQS excesses were observed in sediment were not verified.

Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications.

Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers. On the other hand, biomedical application of graphene is a relatively new front with significant potential. Many recent reports have indicated that understanding of graphene-cell (or tissue, organ) interactions; particularly the cellular uptake mechanisms are still challenging. Therefore, use of graphene or graphene oxide properly embedded in suitable PLA matrices can positively impact and accelerate the growth, differentiation, and proliferation of stem cells, conceivably minimizing concerns over cytotoxicity of graphene. As such, PLA-graphene composites hold great promise in tissue engineering, regenerative medicine, and in other biomedical fields. However, since PLA is classified as a hard bio-polyester prone to hydrolysis, understanding and engineering of thermo-mechanical properties of PLA-graphene composites are very crucial for such cutting-edge applications. Hence, this review aims to present an overview of current advances in the preparation and applications of PLA-graphene composites and their properties with focus on various biomedical uses such as scaffolds, drug delivery, cancer therapy, and biological imaging, together with a brief discussion on the challenges and perspectives for future research in this field.

In Vitro Release Kinetics of Microencapsulated Materials and the Effect of the Food Matrix.

Many biomaterials are encapsulated to preserve their health-promoting properties and promote targeted delivery. Numerous papers have been published about extraction and purification methods, encapsulation techniques, and release properties of encapsulated biomaterials. Despite the abundant information, the food applications of encapsulated materials are currently limited. One approach to increase the food applications is to investigate the mathematical aspects of release behavior and the effect of the food matrix. Such information is useful in evaluating suitable food matrices and predicting the extent of bioavailability of the biomaterial. This review aims to discuss the kinetic models of release, current efforts to promote sustained release, and food matrices currently used in in vitro investigations. Information from pharmaceutical studies is integrated and reviewed to determine possible food applications. Future research on microencapsulated biomaterials conducted along these aspects may hopefully hasten nutraceutical applications.

Rational Approximation to the Fractional Laplacian Operator in Reaction-Diffusion Problems

This paper provides a new numerical strategy for solving fractional-in-space reaction-diffusion equations on bounded domains under homogeneous Dirichlet boundary conditions. Using the matrix transfer technique the fractional Laplacian operator is replaced by a matrix which, in general, is dense. The approach here presented is based on the approximation of this matrix by the product of two suitable banded matrices. This leads to a semilinear initial value problem in which the matrices involved are sparse. Numerical results are presented to verify the effectiveness of the proposed solution strategy.

Spatial interference shaping for underlay MIMO cognitive networks

Interference temperature (IT) is a widely-used approach for protecting primary users (PUs) from the secondary users (SUs) in underlay cognitive radio. H owever, when multiple antennas are available at the transmitters and receivers, the spatial structure of the interference comes into play, strongly affecting the performance of the primary network. In this work, we propose interference shaping constraints as an alternative to IT-based approaches. Spatial shaping constraints take account of the structure of interference and exploit it in benefit of the secondary network. Moreover, they can be designed dynamically based on the channel conditions and performance requirements of the PUs. We first show that spatial shaping constraints generalize IT, in that the latter can be expressed as a set of isotropic shaping constraints on each interference dimension. Then, we exemplary consider a PU that has a rate requirement, and propose an algorithm for obtaining suitable shaping matrices, which can be easily modified to include primary transmitter cooperation. This algorithm is performed at the primary receiver using only local channel state information. Afterwards, we address the transceiver optimization of the SU, modeled as a multiple-input multiple-output point-to-point link, and provide optimal and suboptimal transmit covariance designs under the proposed shaping constraints.

Structured optimal feedback in multi-agent systems: A static output feedback perspective

In this paper we demonstrate how certain structured feedback gains necessarily emerge as the optimal controller gains in two linear optimal control formulations for multi-agent systems. We consider the cases of linear optimal synchronization and linear optimal centroid stabilization. In the former problem, the considered cost functional integrates squared synchronization error and input, and in the latter, the considered cost functional integrates squared sum of the states and input. Our approach is to view the structures in the feedback gains in terms of a static output feedback with suitable output matrices and to relate this fact with the optimal control formulations. We show that the two considered problems are special cases of a more general case in which the optimal feedback to a linear quadratic regulator problem with cost functionals integrating squared outputs and inputs is a static output feedback. A treatment in this light leads to a very simple and general solution which significantly generalizes a recent result for the linear optimal synchronization problem. We illustrate the general problem in a geometric light.

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review.

Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvantages. These scaffolds are either made up of highly biocompatible natural biomaterials, such as collagen, chitosan, etc., or synthetic materials, such as polycaprolactone (PCL), and poly-ethylene-glycol (PEG), etc. Composite scaffolds, which are a combination of natural or synthetic biomaterials, are highly biocompatible with improved tensile strength for effective skin tissue regeneration. Appropriate knowledge of the properties, advantages and disadvantages of various biomaterials and scaffolds will accelerate the production of suitable scaffolds for skin tissue regeneration applications. At the same time, emphasis on some of the leading challenges in the field of skin tissue engineering, such as cell interaction with scaffolds, faster cellular proliferation/differentiation, and vascularization of engineered tissues, is inevitable. In this review, we discuss various types of scaffolding approaches and biomaterials used in the field of skin tissue engineering and more importantly their future prospects in skin tissue regeneration efforts.