Sugar Coat Research Articles

Application of Laser Hologram Interferometry to the Distortion Determination of Sugar-Coated Tablets

AbstractSugar-Coated tablets of different core materials were prepared and the degree of distortion of the sugar coat was determined by the laser holographic interferometry of double exposure method. It was found that, as the degree of expansion of the tablet core material increased, the sugar coat became more distorted. By the present method, nondestructive measurement of a minute amount of distortion is possible and thus superior to conventional methods.

Semiquantitative Investigation of Tablet Coats by Electron Probe Microanalysis

AbstractThe combined, non-destructive techniques of scanning electron microscopy and electron probe X-ray microanalysis were used to investigate the composition of commercial tablets containing a) film and b) sugar coats, before and after a series of processes designed to challenge the integrity of the coatElemental analysis and estimations of coat thickness and integrity were rapidly made with a single tablet. Using the process of X-ray mapping, it was possible to identify chemically, discrete subcoats of the sugar coat which were indistinct on the electron micrograph. Analyses of these substrata may prove useful in assessing adherence to correct coating procedures

Stability of Phenylbutazone in Presence of Pharmaceutical Colors

The degradation of phenylbutazone was studied in the presence of lakes suitable for coloring the sugar coats of phenylbutazone tablets. The drug was degraded, in light, in the presence of erythrosine sodium. The degradation probably proceeds via singlet oxygen generated by the light-excited dye. The degradation may be important in some quality control procedures and can lead, for example, to unusual results in dissolution rate testing.

Ayn Rand's Novels: Art or Tracts? Two Additional Views

IN A RECENT ARTICLE in this Journal, Max E. Fletcher attempts accomplish two things: (a) demonstrate that Harriet Martineau and Ayn Rand, writing 150 years apart, have both devoted themselves using fiction as a vehicle for simplifying and conveying the esoteric theories of laissez-faire economics the reading public; and (b) provide some explanation of the content of Martineau's and Rand's work. Fletcher's thesis is that both these writers had the same purpose or mission, i.e., to convert their reading publics a firm belief in the principles of a self-regulating market system (1). Fletcher then goes on state that, in pursuit of their common purpose, Martineau and Rand reverse the intention of most great novelists create first a work of art, and only secondarily an educational tract. The novels of Martineau and Rand, Fletcher claims, primarily sugar coatings for tracts (2). Perhaps Mr. Fletcher should have concentrated on interpreting the work and purposes of Harriet Martineau. Tn this instance his evidence is persuasive, it is supported by Martineau's autobiographical writing (which Fletcher has troubled himself include), and there are doubtless very few active Martineau scholars today take issue with him. Such is not the case, however, with the work and purposes of Ayn Rand. Fletcher's central thesis, as regards Ayn Rand, is completely mistaken; it is not supported by evidence (even by Fletcher!); it is contradicted by Miss Rand's own autobiographical writing (which Fletcher has not troubled himself include); and there are, today, many active Ayn Rand scholars, one of whom, on the basis of his article, Fletcher evidently is not.

The Role of Automation in Sugar Coating Tablets

AbstractThe development of the sugar coating process into a fully automated operation is reviewed. Progress has been slow with many underlying problems, not the least of which is the lack of reporting of individual progress by the pharmaceutical industry. Three fully automated systems are reported to point out the important role of automation in studying variables involved in sugar coating.

Tablet-to-Tablet Variation of Drug Content of Sugar-Coated Tablets Containing Drug in the Sugar Coat

In dosage forms where active drug is added to a sugar coat, it may be shown that the distribution of assays should be normal and the standard deviation should be proportional to the square root of the number of coats.Although, in a series of batches, the standard deviation was found linearly related to the square root of the number of coats, the plot failed to intersect at the origin and did not have the required slope, presumably due to secondary contributions to the variation such as pan build-up.

Application of Sugar Coating to Tablets and Confections by Means of an Automated Airless Spray System I: Investigation of the Direct Coating of Tablets

The practicability of directly applying sugar coating to unsubcoated tablets has been studied. Initial work performed indicates that such a procedure may be feasible when used in place of current sugar-coating techniques.

Calorie Content of Sugar-Coated Tablets

<h3>To the Editor:—</h3> Quite frequently the question is posed by members of the medical profession as to the caloric content of a sugar-coated tablet. This question is understandable, since certain types of tablet coatings have been advertised to be noncaloric, with the inference that a sugar coating might be harmful. For this reason, some concern is created in the minds of physicians as to the caloric content of standard sugar coatings. We should like to point out that the amount of sugar in the coating of a tablet is negligible. For example, the amount of sugar present in an enteric-coated 5-grain (0.325-gm.) aspirin tablet (usually much larger than most coated tablets) is 175 mg., which would represent a caloric content of 0.7 calories. Even with multiple daily dosage, it is difficult to imagine any pathological condition in which this amount of sucrose would be contraindicated.

Note on a Revised Sugar Coating Procedure for Tablets

A method is presented which describes a revised sugar coating procedure. The procedure eliminates the rounding and smoothing operations usually employed in pan-coated tablets. The resulting coating is approximately one-half as thick as the standard method and coating time is greatly reduced.

The Use of Polyethylene Glycol in Tablet Coating

An improved method for the coating of medicinal tablets using polyethylene glycol 6000 has been developed as a result of this investigation. Using conventional tablet coating equipment but none of the conventional materials, this process is offered as a replacement for the usual sugar coatings over which it possesses many distinct advantages. With this new process, tablet coatings have been produced which are stable, durable, readily water-soluble, and evenly colored. The time required for the application of this coating is less than half that currently spent in sugar coating and since no water is used in the coating solutions, the need for protective coatings is eliminated. The polyethylene glycol used is nonhygroscopic, noncaloric, and relatively nontoxic. Its solubility in a variety of common solvents makes the new process very flexible.