Abstract
In dosage forms where active drug is added to a sugar coat, it may be shown that the distribution of assays should be normal and the standard deviation should be proportional to the square root of the number of coats.Although, in a series of batches, the standard deviation was found linearly related to the square root of the number of coats, the plot failed to intersect at the origin and did not have the required slope, presumably due to secondary contributions to the variation such as pan build-up.
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