Field trials were conducted during the 2015/16 and 2016/17 dry seasons. The aim was to study the effects of NPK fertilizer rates on tuber carbohydrates and crude protein (CP) of three varieties of potato (Solanum tuberosum L.). The research was conducted at Teaching and Research Farm of Kebbi State University of Science and Technology, Aliero, located at Jega in the Sudan savanna zone of Nigeria. Treatments consist of four rates of NPK [20:10:10] fertilizer (0, 300, 600 and 900kg NPK ha-1) and three varieties (Bertita, Diamant and Nicola) of potato. Factorial combinations of fertilizer rates and varieties were laid out in a randomized complete block design, replicated three times. The size of each plot was 4.5 x 3 m (13.5m2). Results revealed that CP was affected by the dosage of fertilizer applied. 600 kg NPK ha-1 gave the highest CP above which there was no significant increase. Higher tuber carbohydrate content was recorded by Nicola and Bertita than Diamant; while crude protein was highest in Bertita compared to Nicola and Diamant. In this study, Bertita variety was higher in crude protein; and was comparable to Nicola, Bertita was lower (p ≤ 0.05) than Nicola and Diamant in carbohydrates. The use of 600 kg NPK ha-1 was optimum for good tuber quality.