The need to apply innovations in the production of products and the provision of services in the current conditions of sanctions and a total policy of import substitution is beyond doubt. Replacing imports with domestic goods and components is a priority task of state policy in the Russian Federation. The published article discusses theoretical approaches to the study of innovative activity of the regional industrial complex. The authors substantiate the need to apply innovations at the level of the regional industrial complex in terms of improving the regional production system. The essential features of the innovative activity of enterprises are given, the main approaches to its definition are supplemented. The signs of innovative active enterprises and their differences from traditional ones are highlighted. A set of measures is proposed to promote the development of innovative activity of the industrial complex of the Russian Federation. The criteria for the effectiveness of innovative industrial complexes are outlined. In the conclusion of the presented scientific research, the author's definition of innovative activity of enterprises of the regional industrial complex is given, which is the intensity of the innovative activity of enterprises in the region, determined by the frequency of application of innovations in production from the generation of knowledge, ideas to commercialization and obtaining financial benefits.
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