The smart substation in this paper is a model. Through the research of its primary system, the project construction scale and design scope, electrical main wiring, short-circuit current and main equipment selection, insulation coordination and overvoltage protection, cable facilities, power distribution equipment, etc. To conduct research. Analyze application status detection, fully optimize design, and improve operation and maintenance management. Combining the online monitoring and sequential control operation of the intelligent substation, the research of the secondary protection design scheme is carried out. It analyses the system dispatch automation, integrated power supply system, system and station communication, secondary equipment cabinet and layout, component protection and automatic equipment, etc., focusing on online monitoring, sequential control operation and operation and maintenance management. With the maturity of online monitoring technology, the realization of sequence control operation technology and the application of optical fibre network in real-time systems, the safety level and operation and maintenance management of smart substations will surely be better improved.