Couples seeking infertility treatments are driven to achieve parenthood but many also strive to create families with more than one child. Recognizing the family priorities of infertile couples should be an important aspect of their clinical management. The aim of this study was to determine the likelihood for good prognosis infertility patients to create a family from a single oocyte retrieval and successive euploid blastocyst frozen embryo transfers (FETs). Single IVF center retrospective study. Infertility patients (n=615; mean maternal age = 36.2 years) with good ovarian reserve using autologous oocytes underwent a single oocyte retrieval and >1 euploid blastocyst FET (mean 2.3 FETs per infertile couple). Normally fertilized embryos were cultured to the blastocyst stage for trophectoderm biopsy and comprehensive chromosome screening (CCS) was performed prior to vitrification. Standard protocols for a hormone replacement FET were utilized. Analysis was performed to determine the probability of achieving a live birth following successive FETs of euploid blastocysts originating from their initial oocyte retrieval. Statistical analysis included Student’s t-test, ANOVA and Fisher’s exact where appropriate, with significance at P<0.05. Following a live birth outcome from the first euploid blastocyst FET, 62.5% of infertile patients were successful again with their second euploid blastocyst FET, thereby allowing these couples the opportunity to achieve families of more than one child from their initial oocyte retrieval. Remarkably, similar success was observed in the second FET for infertile patients that failed with their first euploid blastocyst transfer (58.7%; ns). This trend continued for the third euploid blastocyst FET, with equivalent live birth rates, independent of the outcome of the preceding euploid blastocyst transfer (previous FET success = 50.7% vs. previous FET failure = 50.9%; ns). Only 23 patients pursued a fourth euploid blastocyst FET for additional children, with a 47.8% chance of success. Overall the live birth rate did significantly decline with each subsequent euploid blastocyst FET (First FET=72.3%; Second FET=60.4%; Third FET=50.7%; Fourth FET=47.8%; P<0.0001). This was not surprising since euploid blastocyst morphology was typically lower with successive FETs, and data has shown that euploid blastocyst morphology has a significant impact on IVF outcomes. Good prognosis infertile couples pursuing single oocyte retrieval with CCS, followed by successive euploid blastocyst FETs, can successfully fulfill their desire for parenthood and the creation of a family with more than one child. Additionally, subsequent euploid blastocyst transfers have a high probability of success even after an initial FET failure/s.