Objective To discuss the cause of relapse after the first surgery of varicose veins of lower limb, and corresponding prevention and treatment methods. Methods The data of 81 cases of recurrence varicose veins of lower limb in Department of Vascular Surgery, Yanzhou First People′s Hospital from September 2010 to October 2016 were analyzed retrospectively, all patients receded ascending phlebography for deep veins Postoperative follow-up of 6 to 48 months was followed by the combination of outpatient and telephone follow-up, with the symptoms, signs and blood vessels of the lower extremities as the follow-up. Results Remnant of the main trunk or tributaries of great saphenous vein in 19 cases, 31 limbs of deep venous incompetent, incompetent perforator veins 25 limbs, the residual of small saphenous vein were 3 cases, crockett’s syndrome 10 cases, sequelae of deep venous thrombosis belongs to the residual 5 limbs, Klippel-Trenaunay syndrome 1 limbs. There were some patients who suffered from 2 reasons or more than two reasons simultaneously.After surgery again, the cure vate was 100% and no serious complications such as deep vein throm-bosis.During the follow-up, 12 patients showed different degrees of subcutaneous stasis, oral drug observation, and later regression. Local subcutaneous hematoma was 5 cases, 2 cases of pure syringe were treated with pressure after suction, 3 routine local incision was removed to remove stitches, drainage change and delayed healing. Six patients showed the sensory impairment of skin numbness in the leg boot area, and oral related neurotrophic drugs improved within 1 to 6 months after surgery. The remaining patients recovered well after operation. Conclusions Various causes can lead to the varicose vein of lower limb, a varicose vein of lower limb is a common clinical symptoms of many different diseases. Preoperative comprehensive examination to clarify the cause, this will help to reduce the probability of recurrence of lower extremity varicose veins. Key words: Recurrence, cause; Angiography; Varicose veins