Objective To explore application of bundles of care intervention in rehabilitation of patients with breast cancer after radical mastectomy (BCARM) , so as to improve the patients' quality of life, and to provide reference basis for rehabilitation nursing for patients with BCARM. Methods A total of 195 cases with BCARM treated in Department of Breast Surgery, the Fourth Affiliated Hospital of Guangxi Medical University from January 2014 to April 2015 were selected and divided randomly into experiment group with 97 cases and control group with 98 cases. Patients in the control group received routine care for breast cancer, while those in the experimental group received bundles of care intervention. Incidence of postoperative subcutaneous effusion, skin flap nectosis, upper limb edema, and bleeding of patients in the two groups were compared, together with motion range of joints in the affected limb when extending outward and backward, and quality of life of the patients. Results After the surgery, subcutaneous effusion occurred to 17 patients in the experiment group, and upper limb edema to 19, which were obviously less than that in the control group, with subcutaneous effusion to 20 and upper limb edema to 22 (χ2 =12.311, 14.030; P<0.01) . 4 weeks and 12 weeks after the surgery, outward extending degree of the affected limb in the experiment group were (130.01±6.16) ° and (135.51±4.65) ° , and the backward extending degree (38.92±4.28) ° and (39.53±4.02) ° , obviously better than that in the control group, with outward extending degree of (128.18±7.35) °, (130.04±6.11) °, and backward extending degree of (36.61±4.13) ° and (38.99±4.63) °. At 4 weeks and 12 weeks after the surgery, there was statistical difference between numbers of the time points, groups, and interaction between the groups and time (P<0.05) . At 6 months and 12 months after the surgery, the measured scores of quality of life in the experiment group were (16.80±3.29) points and (19.00±2.27) points, with scores of additional attention (21.95±3.39) points and (22.24±3.06) points, with the scores in the control group (14.20±3.39) , (15.59±2.91) , (20.55±3.34) and (20.96±2.79) . At 6 months and 12 months after the surgery, there was statistical difference between numbers of the time points, groups, and interaction between group and time (P<0.05) . Conclusions The effect of bundles of care intervention on rehabilitation of patients with BCARM is far better than traditional nursing methods. Key words: Breast neoplasms; Rehabilitation; Bundles of care intervention; Breast cancer after modified radical mastectomy