Translation Studies Research Articles

Narrative reconstruction of events in novel translation: A case study of the English translation of Xuemo’s works

Drawing inspiration from Prince’s (2012) discourse on narrative events, this study investigates how translators reconstruct narrative events in novel translation. The results indicate that, in terms of narrative completeness, the addition of events such as detailed conflicts, background explanations, and narrative beginnings mitigates the cognitive disparity among target readers. This is achieved by furnishing them with the cultural knowledge necessary to decode text originating from a different cultural context. Regarding the temporal arrangement, the translator restructures the sequence of events by commencing with emotional events and reinstating the original chronological order to cater to target readers’ reading habits. Additionally, the reorganization of interconnected events according to thematic and character-based considerations enhances the readability of the target text. This research illuminates the significance of event reconstruction in novel translation and provides implications for both translators and scholars. By comprehending the effects of adding, rearranging, and reorganizing events, translators can adeptly adapt the narrative structure of a novel to align with the cognitive context and the reading preferences of readers in the target language.

Exploring the Cultural Dimensions of Translation: A Critical Analysis of Snell-Hornby's Approach

This paper analyzes Mary Snell-Hornby's seminal theoretical framework for understanding translation as an inherently cultural process. Snell-Hornby was pioneering in establishing that translation requires navigating differences in worldviews and cultural competence. Key concepts explored are culture-bound language elements, the role of expertise, and translation studies' interdisciplinarity. Practical linguistic and textual challenges posed by cultural variation are examined, along with proposed strategies for references and idioms. Case studies reveal cultural influences on translation processes and outcomes. A critical evaluation identifies strengths like emphasizing culture's centrality, and limitations addressed in later frameworks. Potential areas for further research building on Snell-Hornby's foundations are identifying, such as localized case studies, evolving digital implications, and refinement of guidance. Overall, Snell-Hornby established culture as integral to conceptualizing translation's complexities, with implications for both theory development and stewardship of cross-cultural exchange.

Developing Transcreation Skills in Translation Studies: Training University Lectures to Address Demands for Creative Translation

The relevance of transcreation skills goes beyond mere translation strategy to a more sought-after service, that help equip translators with relevant employability skills. Nevertheless, the concern for the high demands of translators who possess these skills calls for a thorough training of future translators to acquire these skills. On the other hand, this will be possible if translator educators are already equipped with these skills. As such, this study aims to explore how translation educators, specifically, university lecturers can be prepared to effectively address the growing need for transcreation skills. The research further explores practical techniques and approaches aimed at teaching instructors to successfully impart transcreation abilities and adequately equip students for employment in creative translation. In order to achieve the objective of this research, a quantitative research methodology was adopted, and an online research questionnaire was also utilized. Moreover, a total of ninety-seven (97) study participants were included in the online survey to express their perspectives on how the university lecturers can be trained to address demands for creative translation. The participants' replies, which constitute the primary dataset for this study, were presented and subjected to thorough analysis. Additionally, these replies provided additional clarification on the two fundamental study hypotheses. The study results highlighted several fundamental elements connected with transcreation skills, including bilingual proficiency, creative writing, cultural sensitivity, and multimedia proficiency. Based on the analyzed data, the research revealed that adoption of practical strategies and methodologies such as professional development, inclusion of transcreation projects in translation training module, collaboration with industry experts, and technology integration helps to train translation educators to effectively teach transcreation skills. The study, however, recommends combination of these identified strategies for effective training of university lecturers.

Exploring the Use of Subtitling in Teaching and Learning English as a Foreign Language: Theories and Applications

Technology occupies a significant resource that can be exploited empirically to contribute to translation learning and research, as it can give enormous opportunities for language learners and educators to exploit in their teaching and provide students with practical learning activities. Many researchers highly recommend the extensive use of IT in enhancing the competence of translation students and L2 learners' language skills. Since there has been an abundance of empirical research studies carried out over the last two decades, many novice researchers cannot review and handle them within their limited time. For this reason, this paper introduces the key researchers who carried out studies on the employment of audiovisual translation (AVT) in language learning and teaching; it explores and reviews the main previous research studies conducted on the impact of audiovisual translation, namely subtitling and subtitles on enhancing language learning. It first considers briefly how audiovisual translation emerged as an independent branch of Translation Studies (ST), then discusses its development as well as its continuity within Translation Studies. It also explores its classifications and highlights future research avenues.

Translating Inter-country Adoption as Transcultural Communication

This article attempts to explore transcultural communication through the translated version of “Inter-country Adoption” of the National Civil Code, 2017 ( the Muluki Dewani Samhita) Ain, 2074 BS). It observes the “Hague Adoption Convention, 1993” principles and the Manu’s idea of dharmaputra (adopted sob) mentioned in the “Manusmriti”, the law of Hindu, and its influence on the formation of adoption law in Nepal. The primary purpose of Nepali legal translation is to transfer Nepali legal culture for global communication. The cultural theory of translation developed by Lawrence Venuti and Marry Snell-Hornby and the equivalence theory of Eugene Nida and Peter Newmark are were used as the theoretical base for the study. The significance of this study is to the parents waiting for inter-country adoption and to the university students who have taken translation studies as their major subject. This article concludes that legal translation in Nepal is a strategy to deliver Nepali legal culture to the globe and vice versa.

Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells.

Prostate cancer (PCa) is the second critical cause of cancer-related deaths, with African Americans dying at higher rates in the U.S. The main reasons for the higher mortality rate are ethnic differences and lack of understanding of prostate cancer biology and affordable treatments, as well as the financial burden of African American men to obtain the most effective and safe treatments. The effect of micronutrients, including Vitamin K, on various cancer cell lines has been widely studied, but the potential anticancer effect of VK3-OCH3, an analog of vitamin K3 (Menadione), on African American prostate cancer has not been evaluated. In this study, we compared the anticancer effect of VK3-OCH3 on targeting African American derived PCa cell lines namely RC77-T and MDA-PCa-2b. Our results show that VK3-OCH3 significantly inhibits the proliferation of both RC77-T and MDA-PCa-2b African American PCa cells and promotes apoptosis, and the underlying mechanism of cell death appears to be similar in both the cell lines. Notably, VK3-OCH3 inhibits colony-forming ability and induces apoptosis by blocking the cell cycle at G0 in African American PCa cells. VK3-OCH3 also acts as an anti-metastatic agent by inhibiting the migration ability of the metastatic properties of African American PCa cells. The cell death of African American PCa cells mediated by VK3-OCH3 is associated with the production of free radicals, such as intracellular and mitochondrial reactive oxygen species (ROS). Interestingly, antioxidants such as N-Acetylcysteine (NAC) and Glutathione (GSH) effectively negated the oxidative stress induced by VK3-OCH3 on PCa cell lines derived from African American patients. Of note, VK3-OCH3 reduces androgen receptor and prostate-specific antigen expression in these PCa cells. Furthermore, molecular dynamic studies reiterated that VK3-OCH3 strongly binds to the androgen receptor, suggesting that the androgen receptor is the potential molecular target of VK3-OCH3. In addition, Western blot analysis showed that VK3-OCH3 reduces the expression of androgen receptor, TRX2, and anti-apoptotic signaling molecules such as Bcl-2 and TCTP in the MDA-PCa-2b metastatic PCa cellular model. In conclusion, our results suggested that VK3-OCH3 is a promising anticancer agent that could potentially reduce the mortality rates of African American PCa patients, warranting further preclinical and translational studies.

Aspects of translation of Russian linguistic realities of N.V. Gogol’s novel “Dead Souls” into Chinese language

Abstract In the modern world, characterised by the increasing popularity of world literature, there exists an escalating demand for accurate and culturally adapted translations that convey the semantic accuracy and meaning of the original text. The purpose of this study is to analyze the specific features of translating antonyms into Chinese reflecting everyday realities in N.V. Gogol’s novel “Dead Souls”. The following methods were used to achieve the research objectives: hypothetical-deductive, content analysis, and comparative. The study determined that the novel “Dead Souls” is rich in Russian everyday realities and antonyms that convey the linguocultural features of the time within the context of the literary work. In addition, it was revealed that translators face the challenge of conveying Russian everyday realities and cultural features in the Chinese translation. This includes the problem of adapting antonyms that may be unfamiliar or have a different meaning in Chinese culture. The translation of antonyms must maintain semantic accuracy and comparability with the original to convey the meaning and contrast that antonyms create in the text. The study showed that the translation of antonyms can influence Chinese readers’ perception of the text. Their correct rendering preserves the meaning and structure of the original, which is significant for a full understanding of the literary work. As a result of a comparative analysis of Chinese translations of N.V. Gogol’s novel “Dead Souls”, various aspects influencing the translation of antonyms and their role in conveying Russian everyday realities were revealed. Practical significance lies in the use of the findings of this study by the researchers engaged in the translation of literary works, as well as specialists in the fields of literary studies, linguistics, and translation studies.

Writing Confucian History in an Indian Language

Abstract This article uses a case study of an Urdu translation of the classical Chinese Shujing (Book of Documents) to bring to light a process of multiperson, mediated, and ultimately transimperial translation in which European source texts played crucial roles in transmitting detailed knowledge of China to the Indian public sphere. After outlining the theoretical approach of transimperial history and its value for Asian intellectual history, the article positions the Urdu Shujing in relation to earlier Indian and Middle Eastern accounts of China whose triangulated transmission—from East Asia to Europe and thence to South or West Asia—set various precedents for the translation of the Shujing from a prior English translation. The article then focuses on the Urdu version to reveal the transimperial mechanisms it used to not only translate and transliterate classical Chinese, but also to “transcalculate” dates and render Chinese history comparable to both Europe's and India's past. The conclusions argue that, from Ming China via the early modern Catholic empires to the occult subcurrents of British colonial culture, the transimperial pathways along which Confucian history reached India were ultimately Eurasian rather than narrowly inter-Asian in scope. This reliance on earlier European translations would later recur with the spread of “world literature” in the postcolonial era.

The Chinese version of the tendency to stigmatize epidemic diseases scale: a translation and validation study.

To translate the Tendency to Stigmatize Epidemics Diseases Scale (TSEDS) into Chinese and to evaluate its psychometric properties. Translation and cross-cultural adaptation using the Brislin translation model, and pre-testing to form a Chinese version of TSEDS. A total of 434 adults participated in the study and the TSEDS were measured using the critical ratio method, Pearson correlation analysis, retest reliability, content validity, structural validity, and concurrent validity. The Chinese version of the TSEDS scale contains 27 items in 5 dimensions, including structural stigma, perceived stigma, organizational stigma, internalized stigma, and social stigma. The average content validity index of the scale was 0.975. The goodness of fit index (χ2/df= 1.981, RMSEA = 0.067, CFI= 0.930, IFI = 0.931, TLI = 0.922) indicated a good model fit. The Cronbach's alpha coefficient was 0.962 and the dimensionality ranged from 0.882 to 0.928. The retest reliability was 0.912. The Chinese version of TSEDS has good reliability and validity, which can be used to assess the epidemiological stigma tendency of Chinese adults.

Dose Considerations for Vaccinia Oncolytic Virus Based on Retrospective Reanalysis of Early and Late Clinical Trials.

Over the past decade, oncolytic viruses (OVs) have been developed as a promising treatment alone or in combination in immuno-oncology but have faced challenges in late-stage clinical trials. Our retrospective reanalysis of vaccinia oncolytic virus (VOV) clinical trials indicates that lower doses-rather than the maximum tolerated dose (MTD)-are associated with better tumor response rates. Patients who responded well to lower doses generally had prolonged survival rates in the early phase clinical trial. The association between poor outcomes and an increase in OV-induced neutrophils (OV-N) but not baseline neutrophil counts suggests the need for a comprehensive characterization of OV-N. Although this reanalysis is limited by patient heterogeneity-including differences in cancer type and stage, treatment schedules, and administration routes-it remains informative given the complexities of translational studies in the tumor-bearing mouse models of vaccinia oncolytic viruses. Notably, while OV-N increases with higher viral doses, the immune state shaped by tumor progression likely amplifies this tendency. These findings highlight the importance of OV-N immune modulation as well as dose optimization for the successful clinical development of VOV.

The Metamorphosis of the Novel <i>Moment in Peking</i> in Japan, Taiwan, and China

This article focuses on the migration of Lin Yutang’s most-read novel, Moment in Peking (1939), across linguistic, geographic, and media boundaries in East Asia from the 1940s to recent times. It aims to reveal how this novel, originally composed in English and published in the US during the War of Resistance against Japanese Aggression, is translated, adapted, presented, and situated in different literary, cultural and ideological contexts in Japan, Taiwan and Mainland China. Drawing on the principles of Linda Hutcheon’s theory of adaptation and the Manipulation School’s literary translation studies, my analysis highlights the agency of translators, adaptors and publishers in literary production conditioned by the evolving social, historical and political circumstances. The research contends that the metamorphosis of Moment in Peking embodies a literary power game directly linked to shifts in power dynamics between the three entities. At the cultural level, it provides insights into the intricate interplay of three distinct cultural imageries—competing, conflicting or assimilating within a relational framework.

Progress towards understanding risk factor mechanisms in the development of autism spectrum disorders.

Autism spectrum disorders (ASD) are a heterogenous set of syndromes characterised by social impairment and cognitive symptoms. Currently, there are limited treatment options available to help people with ASD manage their symptoms. Understanding the biological mechanisms that result in ASD diagnosis and symptomatology is an essential step in developing new interventional strategies. Human genetic studies have identified common gene variants of small effect and rare risk genes and copy number variants (CNVs) that substantially increase the risk of developing ASD. Reverse translational studies using rodent models based on these genetic variants provide new insight into the biological basis of ASD. Here we review recent findings from three ASD associated CNV mouse models (16p11.2, 2p16.3 and 22q11.2 deletion) that show behavioural and cognitive phenotypes relevant to ASD. These models have identified disturbed excitation-inhibition neurotransmitter balance, evidenced by dysfunctional glutamate and GABA signalling, as a key aetiological mechanism. These models also provide emerging evidence for serotoninergic neurotransmitter system dysfunction, although more work is needed to clarify the nature of this. At the brain network level, prefrontal cortex (PFC) dysfunctional connectivity is also evident across these models, supporting disturbed PFC function as a key nexus in ASD aetiology. Overall, published data highlight the utility and valuable insight gained into ASD aetiology from preclinical CNV mouse models. These have identified key aetiological mechanisms that represent putative novel therapeutic targets for the treatment of ASD symptoms, making them useful translational models for future drug discovery, development and validation.

Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study.

Penile squamous cell carcinoma (PSCC) is a rare malignancy. However, in developing countries the incidence rate is higher. The understanding of molecular alterations is essential for evaluating possible targets for more effective systemic therapies. We retrospectively collected clinical data of metastaticPSCC (mPSCC) patients who had received at least one prior systemic treatment from 3 Brazilian hospitals. Tumor samples were evaluated using the next-generation sequencing (NGS) Foundation One DX and immunohistochemistry (IHC). The objective was to identify and describe somatic genomic alterations known to be functional or pathogenic and their association with survival outcomes. Twenty-three patients were identified, 22 and 18 patients had tumor samples analyzed by IHC and NGS, respectively. PD-L1 expression (CPS ≥ 1%) was positive in 14 patients (63.6%). Regarding the genomic alterations, 16 patients (88.9%) had some clinically relevant genomic alterations. TP53, TERT, CDKN2A, PIK3CA, NOTCH1, and CDKN2B loss were identified in 66.7%, 50%, 50%, 33.3%, 27.8%, and 22.2% of the patients, respectively. No MSI or TMB high (≥10 mutations/MB) cases were identified. NOTCH1 mutation was identified only in HPV-negative patients and it was associated with worse OS (yes: 5.5 vs no: 12.8 months, P = .049) and progression-free survival (yes: 5.5 vs no: 11.7 months, P = .032). This study demonstrated that molecular alterations in mPSCC from developing countries are similar to those from developed countries. Predictive biomarkers for immunotherapy response such as TMB high or MSI were not identified. Specific gene mutations may identify patients with worse prognoses and open new avenues for therapeutic development.

Artificial Intelligence In Translation Studies: Benefits, Challenges, And Future Directions>

Artificial Intelligence In Translation Studies: Benefits, Challenges, And Future Directions>

Genetically Modified Porcine Kidneys Have Sufficient Tissue Integrity for Use in Pig-to-Human Xenotransplantation.

We sought to determine if genetically modified porcine kidneys used for xenotransplantation had sufficient tissue integrity to support long-term function in a human recipient. Kidney transplantation remains the best available treatment for patients with end-stage kidney disease. However, a shortage of available donor human kidneys prevents many patients from achieving the benefits of transplantation. Xenotransplantation is a potential solution to this shortage. Recent pre-clinical human studies have demonstrated kidneys from genetically modified pig donors can be transplanted without hyperacute rejection and are capable of providing creatinine and other solute clearance. It is unknown whether the porcine kidneys would tolerate the relatively higher resting blood pressure in an adult human recipient compared with the pig donor or non-human primate (NHP) recipients used in translational studies. Furthermore, previous experience in NHPs raised concerns about the tissue integrity of the porcine ureter and post-xenotransplant growth of the porcine kidney. Kidneys recovered from porcine donors with 10 gene edits were transplanted into decedent brain-dead recipients who were not eligible for organ donation. Decedents underwent bilateral native nephrectomy before transplant and were followed for 3 to 7 days. Standard induction and maintenance immunosuppression was used as previously reported. Vital signs, including blood pressure, were recorded frequently. Kidney xenografts were assessed daily, serially biopsied, and were measured at implantation and study completion. Three decedents underwent successful xenotransplantation. Subcapsular hematomas developed, requiring incision of the xenograft capsules to prevent Page kidney. Blood pressures were maintained in a physiologic range for adult humans (median arterial pressures (MAP) 108.5mmHg (Interquartile Range (IQR): 97-114mmHg), 74mmHg (IQR: 71-78mmHg), and 95mmHg (IQR: 88-99mmHg, respectively) and no bleeding complications or aneurysm formation was observed. Serial biopsies were taken from the xenografts without apparent loss of tissue integrity despite the lack of a capsule. Ureteroneocystotomies remained intact without evidence of urine leak. Xenograft growth was observed, but plateaued, in 1 decedent with increased volume of the left and right xenografts by 25% and 26%, respectively, and in the context of human growth hormone levels consistently less <0.1ng/ml and insulin-like growth factor 1 levels ranging from 34-50ng/ml. The findings of this study suggest kidneys from 10-gene edited porcine donors have sufficient tissue integrity to tolerate xenotransplantation into a living human recipient. There was no evidence of anastomotic complications, and the xenografts tolerated needle biopsy without issue. Xenograft growth occurred but plateaued by the study end; further observation and investigation will be required to confirm this finding and elucidate underlying mechanisms.

1040P Chemotherapy remodels the tumor immune microenvironment to increase the pCR rate of anti-PD-1 neoadjuvant therapy in MSS/pMMR locally advanced colon cancer: A prospective clinical trial and translational study

1040P Chemotherapy remodels the tumor immune microenvironment to increase the pCR rate of anti-PD-1 neoadjuvant therapy in MSS/pMMR locally advanced colon cancer: A prospective clinical trial and translational study

Building Bridges Between Technical and Professional Communication and Translation Studies

Building Bridges Between Technical and Professional Communication and Translation Studies

Setting Foundations: An Integrative Literature Review at the Intersections of Technical and Professional Communication and Translation Studies

Setting Foundations: An Integrative Literature Review at the Intersections of Technical and Professional Communication and Translation Studies

P01-73 Development and use of reconstructed respiratory epithelium tissue models from multiple species for translational inhalation studies

P01-73 Development and use of reconstructed respiratory epithelium tissue models from multiple species for translational inhalation studies

Base editing of the GLB1 gene is therapeutic in GM1 gangliosidosis patient-derived cells

GM1 gangliosidosis is an autosomal recessive neurodegenerative lysosomal storage disease caused by pathogenic variants in the GLB1 gene, limiting the production of active lysosomal β-galactosidase. Phenotypic heterogeneity is due in part to variant type, location within GLB1, and the amount of residual enzyme activity; in the most severe form, death occurs in infancy. With no FDA approved therapeutics, development of efficacious strategies for the disease is pivotal. CRISPR/Cas based approaches have revolutionized precision medicine and have been indispensable to the development of treatments for several monogenic disorders with bespoke strategies central to current research pipelines. We used CRISPR/Cas-adenine base editing to correct the GLB1 c.380G>A (p.Cys127Tyr) variant in patient-derived dermal fibroblasts compound heterozygous with the GLB1 c.481T>G (p.Trp161Gly) pathogenic variant. Nucleofection of plasmids encoding the target sgRNA and ABEmax restored the canonical guanine (32.2 ± 2.2 % of the target allele) and synthesis of active β-galactosidase. Analysis of cellular markers of pathology revealed normalization of both primary glycoconjugate storage and lysosomal pathology. Furthermore, analysis of off-target sites nominated by the in silico tools Cas-OFFinder and/or CRISTA revealed no significant editing or indels. This study supports the use of CRISPR/Cas-based approaches for the treatment of GM1 gangliosidosis, and provides foundational data for future translational studies.