Entrepreneurship education in Chinese colleges and universities began in the early 21st century. After more than 20 years of development, it has reached an unprecedented scale. At present, there are many studies on entrepreneurship education for undergraduates in Chinese colleges and universities, but only a few general studies on entrepreneurship education in higher vocational education. Particularly, the analysis of the status quo of students’ entrepreneurship education and the research on the improvement of entrepreneurship education has not yet been widely discussed. This research adopted the semi-structured interview method and used purposive sampling to select 8 students with entrepreneurial willingness in lower grades and 8 in upper grades of higher vocational art and design in the Guangzhou area, as well as 8 students who have succeeded in entrepreneurship after graduation, giving a total of 24 students. The interview was designed based on the concept of Entrepreneurial Thought and Action (ET&A) entrepreneurship education. The interview outline was derived from the three aspects of learning, action, and creation. After the interviews were conducted, coding and qualitative analysis were performed to identify the knowledge and skills required by art students in higher vocational colleges to establish a business, and the problems encountered by successful students in entrepreneurship that might be encountered in the future. Based on the conclusions, the method and content of entrepreneurship education in schools could be improved. In addition, the research results showed that to fulfill the aim of entrepreneurship, art and design students in higher vocational colleges need to learn knowledge and skills such as entrepreneurial courses, professional knowledge, and entrepreneurial skills (competition, training, simulation, practice, etc.). Meanwhile, students who had succeeded in entrepreneurship believed that it was necessary to improve the entrepreneurship education curriculum system, pay attention to entrepreneurship practice teaching, and strengthen the linkage between home, school, and enterprise to promote entrepreneurship learning, thereby enhancing innovation and entrepreneurship ability.