ABSTRACT This 4-year longitudinal study identified the impact of a multifaceted mentoring and tutoring program on the retention and graduation rates of a diverse body of undergraduate college students enrolled in high-risk science courses. Findings revealed that the program was successful in increasing the retention and graduation rates of students who participated in the program. All student cohorts tutored through the program demonstrated significantly higher survival rates when they increased their usage of tutoring, threby demonstrating greater survival to retention. Notably, cohorts with high as well as those with low academic competencies achieved the highest 4-year retention survival probabilities when they participated in six or more tutoring sessions. Additionally, through further analysis, a predictive model derived from this research offers a valuable tool that can be strategically utilized to improve retention and/or graducation outcomes of at-risk populations and underrepresented populations in STEM education.