The article reveals the current trends of innovative development of universities, features of integration in the system "education - science - production - business", considers the formation of innovative organizational structures in higher education. It is substantiated that building a modern competitive economy in Ukraine on the basis of innovation is possible only with the functioning of a full-fledged infrastructure, which should include institutes, universities, technology and science parks, innovation centers, business incubators, technology transfer centers, investment and venture funds, etc. Such structures most effectively ensure the integration of education, science and industry, promote the rapid implementation of advanced discoveries and scientific developments. The integration of science with entrepreneurship ensures the passage of the innovation cycle: a new idea – a prototype - patenting - implementation in production. The analyzed experience of developed countries shows that international processes of integration of education and science with entrepreneurship are very relevant, the dominant role in creating innovative structures belongs to leading research universities, where along with training highly qualified personnel research and innovation are implemented. Analysis of the existing infrastructure of innovation activity in Ukraine on the basis of higher education institutions shows imperfection, if not a practical lack of commercialization of knowledge and technology. This necessitates the formation of an appropriate part of the innovation infrastructure in the university. It is determined that the strategic goal of formation and functioning of technology transfer centers in Ukrainian universities, institutes and research institutions is to create a permanent system of commercial use of science-intensive products - objects of intellectual property as a result of research work of the university in domestic and foreign markets. mutual relations of universities with industry and regions, modern information technologies. To achieve this goal, university technology transfer units need to solve a number of tasks: first, to provide a systematic approach to the analysis of scientific potential of the university, expert analysis of all outstanding publications and R & D contracts "to order"; secondly, to create a bank of current developments; third, to promote the development of the infrastructure of small research and innovation firms; to organize monitoring of inquiries of enterprises, branches concerning science-intensive products; to form innovation-oriented topics of research and development in accordance with the requests ("feedback" with consumers), etc. In addition, the need to spread the practice of CTT on the basis of research universities requires further legislative support for the interaction of innovation actors, government support and encouragement to involve its participants in cooperation, creating mechanisms to intensify innovation companies and private capital.