In the past decades, several iron ore occurrences have been discovered in the Precambrian Belt of southern Cameroon, with focus on their economic potential, and little attention on the deposit type. However, few studies have been geared towards understanding the different deposit types within this region. This paper seeks to provide new insight on the different styles of iron ore mineralisation of two potential, yet least studied iron ore deposits in this region in addition to enhancing exploration efforts within the different prospects. Petrology and geochemistry of rock samples from the Binga and Djadom iron prospects in southern Cameroon are investigated. The structural disposition of the prospects was mapped and cores described, sampled and subsequently analysed to enhance the understanding of the alteration mineralogy, ore mineralogy and textural features of the iron-bearing lithologies. Polished thin sections were studied by standard microscopy while the bulk rock geochemistry was determined by X-ray fluorescence (XRF) for major and trace elements. At Binga, the main rock types are magnetite gneisses, amphibolites, quartz-biotite gneisses, and mafic intrusions, while the main rocks encountered at Djadom are magnetite gneisses, amphibolitic BIFs, quartz-biotite gneisses, amphibolites and fault rocks. At both prospects, the target lithology for iron ore is the magnetite gneiss. The magnetite gneisses at the Binga prospect are weakly to moderately foliated, but strongly foliated at Djadom, and both contain fractures that are healed by irregular magnetite. Magnetite is anhedral to euhedral in outline and it is closely associated with amphibole, garnet and pyroxene. Iron content of the magnetite gneisses ranges from 17.44 - 33.40 wt% (at Binga) and 27.73 - 43.39 wt% (at Djadom) and the ore enrichment process involved progressive loss of silica and aluminium. Trace element concentrations show high contents of Ba, Zn, Cu and V but lower abundances of Sr and Zr, as well as low values for Ti in both prospects. At the Binga iron ore prospect, TiO2 and Al2O3 display a linear co-variation with Zr, while in the Djadom prospect, TiO2, Al2O3 and MgO display a negative co-variation with Zr. The origin of the former could be linked to a magmatic fluid-related process, while the genesis of the later is tied to both skarn formation and hydrothermal enrichment.