Introduction. In design of a life-saving multi-storey building, a seismic isolation system in the form of the kinematic supports is used to ensure the seismic resistance and reduce the seismic loads. The structural system, the computational dynamic model and the results of the intermediate in-situ tests of a life-saving multi-storey building with a kinematic seismic isolation system being built in Grozny have been analysed in the article.Materials and Methods. The research included modeling and computation of the structural system of a building with a kinematic seismic isolation system. In-situ tests were carried out to confirm the working capacity of the seismic isolation system connections.Results. A multi-storey life-saving building was designed according to a frame-core wall structure, where the vertical load-bearing elements were core walls, columns and connections between the columns in the form of the stiffening diaphragms. The high-rise part of a building was designed using a kinematic seismic isolation system consisting of the seismic isolating concrete-filled steel tubular supports. The results of the calculations of the main and specific load combinations and internal forces in the load-bearing structures have been presented.Discussion and Conclusion. The research has shown that the use of the developed structural system of seismic isolation with kinematic supports makes it possible to reduce the seismic loads and the total weight of a building and at the same time to increase its mechanical reliability and safety. The conducted intermediate in-situ tests have confirmed the working capacity of the joints connecting the supports with the monolithic reinforced concrete structures of a building, which makes it possible to implement the kinematic seismic isolation supports into the construction industry practices.