27Al, 51V, 52Cr, 55Mn, 56Fe and 58Ni nuclei are some structural fusion substances. The neutron incident energy around 14–15 MeV is adequate to excite the nucleus for the reactions such as (n, p), (n, d), (n, 2n), (n, t), and (n, α). For fusion reactor technology, the reaction cross-sectional data have a critical importance in fusion reactors and development. Neutron irradiation produces considerable modifications in the mechanical and physical properties of each of the structural fusion material systems raising feasibility questions and design limitations. In this paper, for some structural fusion materials (n, α) reactions such as 52Cr(n, α)49Ti, 51V(n, α)48Si, 27Al(n, α)24Na, 58Ni(n, α)55Fe, 56Fe(n, α)53Cr and 55Mn(n, α)52V were done up to 40 MeV incident neutron energy. In the calculations, the equilibrium and pre-equilibrium impacts have been used. Calculations have been carried out with TALYS 1.9 and EMPIRE 3.2 (Malta) nuclear model codes. Results from performed calculations have been compared with the experimental nuclear reaction data, ENDF/B-VII.b4, JENDL-4.0 and JEFF-3.2 evaluated data.