Abstract The primary goal of the current research paper is to investigate the mechanical and tribological behavior of biologically active glass consisting of 31B2O3-(20-x) SiO2-24.5Na2O-24.5CaO and xSrO (in mol%). The specimens were fabricated partly using bio-waste material, in which Silica and Calcium Oxide were derived from rice husks and egg shells, respectively. The produced specimens underwent immersion in simulated bodily fluid for a week to observe their bioactive response. The bioactive behavior of the samples were examined using X-ray diffraction and FTIR spectroscopy. The compression test and hardness of the specimens were measured using universal testing machine and Vickers micro-hardness tester. Abrasion test of the specimens were performed on pin-on-disc tribometer and the worn-out surfaces were later analyzed using FESEM. The findings from FTIR and XRD analyses validated the existence of a hydroxyapatite layer on the specimen surfaces. Further, XRD data showed an increase in peak intensity after SrO was incorporated, suggesting that it played a supporting role in boosting bioactivity. The mechanical investigations indicated that the addition of SrO adversely affects both hardness and compression strength. The abrasion wear test demonstrated that BSG-5 had the highest wear rate, while BSG-0 exhibited the lowest wear rate among all specimens at a 30 mm track radius. Despite the trade-off between enhanced bioactivity and diminished mechanical strength and wear resistance, incorporating Strontium Oxide makes the glass suitable for applications prioritizing bioactivity, such as bone filling and dental contexts.