Strong Compactness Research Articles

A quantitative model and controlling factors of secondary pore development for tight sandstone reservoirs in the carboniferous Benxi Formation, Ordos Basin, China

As the Ordos Basin is the largest gas-producing area in China, its central and eastern Paleozoic Carboniferous Benxi Formation is poised to become a significant source for increasing reserves and production within the basin. However, the extreme diagenesis, complex pore structure, and strong heterogeneity of this formation hinder the exploration of its “sweet spots”. The reasons are usually considered to be its large burial depth (>3000 m), differential uplift, highly acidic environment and strong hydrocarbon supply in the coal-bearing strata of this area. In this study, we performed qualitative and quantitative analyses of thin sections of Benxi Formation rocks, combined with scanning electron microscopy, X-ray diffraction, and fluid inclusion analyses to determine the development, type, and evolution sequence of secondary porosity from the diagenesis of the Benxi Formation. The main reservoir type of the Benxi Formation is characterized by secondarily dissolved pores (>0.5 μm) and micropores (<0.5 μm) within clay aggregates; the low porosity and permeability of <5.8% and <1 × 10−3 μm2 indicating a tight sandstone reservoir. Throughout the reservoir formation, its porosity has decreased by strong compaction and cementation, and also increased primarily by dissolution. Quantitative analyses of the thin-section porosity of the rocks based on the Scherer initial porosity recovery model and pore evolution parameters defined by Paxton and Ehrenberg showed 39.8% recovery of original porosity and a porosity increase due to dissolution of 1.0–5.4% (mean, 4.1%); this constituted 40–250% of the porosity prior to dissolution. The model-simulated results were closely correlated with the experimental measurements. The lithology, diagenetic fluid, and organic acids of the source rocks jointly controlled the development of secondary pores in the Benxi Formation. These findings indicate that the evolution and controlling factors of secondary pore development must be clarified to identify favorable areas for gas exploration. The results will provide a basis for predicting favorable reservoirs in the tight sandstones of the Benxi Formation in the central and eastern Ordos Basin.

Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

Background: Epigenomes allow the rectification of disordered gene expressions, thereby providing new targets for pharmacological interventions in cancer therapy. The clinical utility of targeting histone H3 lysine tri-methylation (H3K27me3) as an epigenetic hallmark has been demonstrated. However, in actual therapeutic settings, the mechanism by which H3K27me3-targeting therapies exert their effects and the response of tumor cells remain unclear. Results and Discussion: We conducted intensive molecular monitoring of three patients enrolled in the valemetostat first-in-human phase 1 clinical trial (NCT02732275) for adult T-cell leukemia/lymphoma (ATL). Valemetostat was administered orally once daily (200 mg/day) until a sign of disease progression could be observed. The number of abnormal lymphocytes (Ably) in these three patients drastically decreased after one week of treatment. All patients could stay on valemetostat single agent for more than 2 years with acceptable safety and durable response. PBMC samples (n = 55) were collected from these three patients immediately before (Pre) and during treatment, as well as during the progressive disease (PD) stage. Flow cytometry-based histone methylation assay demonstrated that tumor H3K27me3 level was generally high in the Pre-samples, but the valemetostat treatment reduced it to a normal level in all patients. In addition, ChIP sequencing (ChIP-seq) could directly assess how valemetostat affects the tumor epigenome. The pre-treatment tumor cells showed an overall increasing trend in H3K27me3. For all H3K27me3 peaks (51,683 peaks), 85.9% of the peak signals decreased at the average fold-change of 0.742 after the valemetostat treatment. Focusing on the gene loci, an overall decrease could be observed around the TSS and across the gene body. The characteristic H3K27me3 clusters initially observed in the tumor cells were demethylated. We also conducted integrative multilayered single-cell analyses (scATAC-seq and scRNA-seq) and showed that valemetostat abolishes the highly condensed chromatin structure formed by the plastic H3K27me3 and neutralizes multiple gene loci, such as tumor suppressor genes (TSGs), in all patients. These results demonstrated that valemetostat sufficiently restored the epigenome of the tumor cells close to the healthy state, leading to clinical improvements. Although all tested cases showed a durable response for more than 2 years, these responses were eventually interrupted due to the recurrence of ATL. We identified characteristic somatic mutations of EZH2 during clonal repopulation at PD. The identified amino acid substitutions were all located at the interface between EZH2 and valemetostat. Direct evaluation of the H3K27me3 level in the PD sample harboring the acquired EZH2 mutation showed that tumor cells in a hypermethylated state were repopulating. The scATAC-seq analysis also showed strong chromatin compaction of the same gene set occurred in the rapidly propagating resistant clone, indicating that the clonally selected mutations should be responsible for resistance. In patients free of the EZH2 resistant mutations, we detected TET2 mutation or elevated DNMT3A expression in the propagated resistant clones. Genome-wide DNA methylation analysis revealed increased DNA methylation near the TSS in the resistant clones. The genes characterized by the H3K27me3-related chromatin condensation were restored by valemetostat treatment but were again strongly re-condensed by mCpG gain at PD. Consequently, the gene regulation of several important TSGs restored by valemetostat was repressed again. Furthermore, in the single-cell platform, we successfully identified subpopulations with distinct metabolic and gene translation characteristics implicated in primary susceptibility until the acquisition of the heritable (epi)mutations. Conclusion: This study illustrates, for the first time, the molecular and cellular dynamics in patients in response to a molecular-targeting inhibitor designed for histone methyltransferases. Eliminating H3K27me3 leads to the reprogramming of the cancer epigenome, thereby exerting a sustained benefit on tumors. Targeting chromatin homeostasis might provide opportunities for further sustained epigenetic therapies.

Petrology, Physical Properties, and Diagenetic Characteristics of Glutenite Reservoir: An Example from the Upper Urho Formation in Zhongguai Salient, Junggar Basin, China

Abstract The Upper Urho Formation on the northwest margin of the Junggar Basin is a key formation for oil and gas exploration. Based on the core observation, combined with the analysis of cast thin section, scanning electron microscope, energy dispersive spectrum, X-ray diffraction, fluid inclusion, and porosity-permeability test, the petrological characteristics, physical properties, diagenesis types, and their effects on the physical properties of the glutenite reservoir of Upper Urho Formation were studied systematically. The results show that the lithology of reservoir of the Upper Urho Formation in Zhongguai Salient is mainly conglomerate with a small amount of sandstone. The permeability of conglomerate is generally higher than that of sandstone, and the physical properties of granule conglomerate and fine pebble conglomerate are relatively better. The reservoir experienced complicated diagenesis, mainly including compaction, cementation, and dissolution, also including filler shrink seam and metasomatism. At present, the reservoir of Upper Urho Formation in Zhongguai Salient is mainly at the middle diagenetic stage A period and partly at the middle diagenetic stage B period. The original porosity lost by compaction is the largest, which is the fundamental reason for low porosity and low permeability of reservoir. The influence of cementation on reservoir physical properties has two sides. On the one hand, the development of cementation is the main reason for low porosity and low permeability of reservoir. On the other hand, the early cementation resists compaction to a certain extent and provides a material basis for the later dissolution. The reservoir of Upper Urho Formation in Zhongguai Salient is deeply buried and has experienced strong compaction and cementation, and the reservoir properties are poor, but the secondary pore space formed by dissolution improves the reservoir properties to some extent. The study concluded that the dense glutenite reservoirs of the Upper Urho Formation can develop relatively high-quality reservoirs on a local scale, which is of guiding significance for the exploration of the Upper Urho Formation.

Homogenization of a mineral dissolution and precipitation model involving free boundaries at the micro scale

In this work we present the homogenization of a reaction-diffusion model that includes an evolving microstructure. Such type of problems model, for example, mineral dissolution and precipitation in a porous medium. In the initial state, the microscopic geometry is a periodically perforated domain, each perforation being a spherical solid grains. A small parameter ϵ is characterizing both the distance between two neighboring grains, and the radii of the grains. For each grain, the radius depends on the unknown (the solute concentration) at its surface. Therefore, the radii of the grains change in time and are model unknowns, so the model involves free boundaries at the micro scale. In a first step, we transform the evolving micro domain to a fixed, periodically domain. Using the Rothe-method, we prove the existence of a weak solution and obtain a priori estimates that are uniform with respect to ϵ. Finally, letting ϵ→0, we derive a macroscopic model, the solution of which approximates the micro-scale solution. For this, we use the method of two-scale convergence, and obtain strong compactness results enabling to pass to the limit in the nonlinear terms.

Effectiveness of Oil Filling in Tight Sandstone Reservoirs of Yancheng Formation in Ordos Basin

The Ordos basin is one of the important oil-bearing basins in China, with abundant tight sandstone oil resources, wide distribution, and large thickness. It is the most realistic field of unconventional oil and gas exploration in China, and it is also an important oil and gas replacement resource at present. Oil accumulation in tight reservoirs is obviously different from conventional oil and gas accumulation, and the key lies in studying the effectiveness of oil filling in tight reservoirs. In order to solve this problem, this paper takes the tight sandstone reservoir of Member 7 of the Yancheng Formation in Ordos Basin as the research object, introduces the geological characteristics of this area after sorting out the previous research results, carries out the physical simulation experiment of oil filling, studies the relationship between the filling pressure and the lower limit of the filling throat, analyzes the effective accumulation space of the tight sandstone reservoir, defines the oil filling mechanism of the tight sandstone reservoir, and discusses the effectiveness and reservoir-forming effect of oil filling in different types of reservoirs. The results show that the rock types of tight sandstone reservoirs in the 7th member of the Yancheng Formation are mainly lithic feldspathic sandstone and feldspathic lithic sandstone, and the reservoirs have experienced strong compaction and carbonate cementation. The late iron-bearing carbonate cementation has further strengthened the degree of reservoir densification, and the reservoirs have been densified at the time of large-scale oil and gas filling. Through the simulation experiment of oil filling with natural cores with different physical properties, the relationship model between filling pressure and effective accumulation space of different types of tight sandstone reservoirs in Member 7 of the Yancheng Formation is established. With the change in filling pressure, the change trend and range of effective accumulation space of different types of tight sandstone reservoirs are obviously different. According to the relationship model between the filling pressure and the lower limit of the effective filling pore throat, the oil filling effectiveness of different types of tight sandstone reservoirs in the 7th member of the Yancheng Formation is determined. Class I and class II1 reservoirs are effective reservoirs for oil filling of tight sandstone reservoirs, which constitute the main oil-bearing section of tight sandstone reservoirs in member 7 of the Yancheng formation, while class II2 reservoirs are poor tight reservoirs, and class III reservoirs are basically oil-free, which are noneffective reservoirs for oil filling of tight sandstone reservoirs. The results provide theoretical data support for the next step of oil exploration and exploitation in tight sandstone reservoirs.

Densification mechanism of deep low-permeability sandstone reservoir in deltaic depositional setting and its implications for resource development: A case study of the Paleogene reservoirs in Gaoshangpu area of Nanpu sag, China

A better understanding of reservoir densification mechanisms is very important for petroleum exploration and controlling the reservoir quality distribution in low-permeability reservoirs. Low porosity and low permeability, difficult reconstruction, and economic infeasibility are important factors restricting its efficient production. Systematic analysis was performed to study the evolution of different microfacies in the deltaic depositional setting of the Paleogene deep low-permeability Gaoshangpu reservoir, define their genetic mechanisms, delineate the dominant facies belts, and define the favorable diagenetic sequences that are important for exploration of high-quality reservoirs. To understand the tight genesis of the low-permeability reservoirs, we analyzed the sedimentological and diagenetic evolution characteristics of various microfacies (i.e., underwater distributary channel, distributary bay, mouth bar, and front sheet sand) using core data and physical property analysis of the reservoir sand body. The results show the underwater distributary channel and estuary bar sand body with medium-to fine-grained and poor–medium sorting. The diagenesis is dominated by strong compaction, calcareous, argillaceous cementation, and dissolution during stage B in early diagenesis and stage A in middle diagenesis. In the fan delta environment, the weak anti-compaction resistance of low-permeability reservoirs is mainly due to the large content of plastic particles, finer grain size, and medium–poor sorting, with an average porosity reduction rate of 65%. This is a key factor for densification of reservoirs above 3000 m. Comparison among different sandstone microfacies of the deltaic setting shows that the sand body of the underwater distributary channel with low shale content has slightly stronger compaction resistance. The porosity reduction is not obvious at the depth of 3,000–4,000 m, but the loss of permeability at this depth section is significant, and the reservoir improvement from later dissolution is most obvious at this depth section. Calcareous cementation is the cause for densification of some mouth bars in the early stage and of underwater distributary channels in the middle and late stage. Under the influence of strong compaction and calcareous-filling pore throat, the sand body of the mouth bar has been basically densified at 3,000 m, resulting in limited reservoir transformation from later dissolution. The study shows that compaction is the main cause of reservoir densification, argillaceous and calcareous cementation is the secondary cause, and later dissolution is another main cause of reservoir enhancement. The research results can provide a reference and direction for reservoir development and search for the high-quality sweet spot in the deep and low-permeability reservoir.

Impacts of Sedimentation and Diagenesis on Deeply Buried Reservoir Quality of a Rift Basin: A Case Study of Wenchang Formation in the Lufeng Depression, Pearl River Mouth Basin, China

The deeply buried reservoirs of Wenchang Formation in the Lufeng Depression, Pearl River Mouth Basin, display strong heterogeneity, and the major controls for the development of high-quality reservoirs remain unclear. To address these issues, we conducted a series of experiment analyses, including petrographic microscope, scanning electron microscopy, and X-ray diffraction, and analyzed the impacts of sedimentation and diagenesis on the quality of deeply buried reservoirs. The results demonstrate that the sandbodies of subaqueous distributary channel and mouth bar deposited in lowstand systems tract (LST) and highstand systems tract (HST), as compared to the beach-bar and subaqueous fan sandstones deposited in transgressive systems tract (TST), have coarser grain size, higher quartz content, and lower muddy matrix content, which induced stronger anti-compaction capability, higher preservation of intergranular pore spaces, and thus better reservoir qualities. The reservoir types developed in subaqueous distributary channel and mouth bar are mainly types I, II, and III with medium-low porosity and low-ultra low permeability, while beach-bar and subaqueous fan mainly developed type III reservoir with low-porosity and ultra-low permeability. The reservoirs developed in E2w of the study area have undergone strong compaction, intense dissolution, but weak cementation. The subaqueous distributary channel and mouth bar reservoirs in LST are adjacent to Ew4 source rock in spatial distribution, resulting in strong organic acid dissolution, and developed numerous dissolved pores. The charging of hydrocarbons before deep burial further inhibited the later compaction and cementation and protects the preservation of residual primary intergranular pores and secondary dissolved pores. The combination of these factors leads to the development of the abnormally high porosity and high-quality reservoirs in LST. The results of this study reveal the genetic mechanism of deep, high-quality reservoirs in the rift basin and guide the selection of high-quality reservoirs in the later stage.

STRONG COMPACTNESS, SQUARE, GCH, AND WOODIN CARDINALS

Abstract We show the consistency, relative to the appropriate supercompactness or strong compactness assumptions, of the existence of a non-supercompact strongly compact cardinal $\kappa _0$ (the least measurable cardinal) exhibiting properties which are impossible when $\kappa _0$ is supercompact. In particular, we construct models in which $\square _{\kappa ^+}$ holds for every inaccessible cardinal $\kappa $ except $\kappa _0$ , GCH fails at every inaccessible cardinal except $\kappa _0$ , and $\kappa _0$ is less than the least Woodin cardinal.

SOLO FTRL ALGORITHM FOR PRODUCTION MANAGEMENT WITH TRANSFER PRICES

We consider a firm producing and selling $d$ commodities, and consisting from $n$ production and $m$ sales divisions. The firm manager tries to stimulate the best division performance by sequentially selecting internal commodity prices (transfer prices). In the static problem under general strong convexity and compactness assumptions we show that the SOLO FTRL algorithm of Orabona and Pal (2018), applied to the dual problem, gives the estimates of order $T^{-1/4}$ in the number $T$ of iterations for the optimality gap and feasibility residuals. This algorithm uses only the information on division reactions to current prices. It does not depend on any parameters and requires no information on the production and cost functions. The results of similar nature are obtained for the dynamic problem, where these functions depend on an i.i.d. sequence of random variables. We present two computer experiments with one and two commodities. In the static case the transfer prices and the difference between the supply and demand demonstrate fast stabilization. In the dynamic case the same quantities fluctuate around equilibrium values after a short transition phase.

Diagenetic controls on the reservoir quality of tight reservoirs in digitate shallow-water lacustrine delta deposits: An example from the Triassic Yanchang Formation, southwestern Ordos Basin, China

Diagenesis is a very important factor to determine the quality of clastic reservoirs, especially in tight sandstone reservoirs. The tight reservoir of Triassic Yanchang Formation in southwestern Ordos Basin is the foremost hydrocarbon exploration target. The shallow-water lacustrine delta developed in Chang 8 reservoir of the study area is distributed in digitate shape, which are mainly composed of distributary channel, continuous mouth bar and together with natural levee above. The typical tight reservoir of Chang 8 member experienced a complex diagenetic evolution process, but the relationship among diagenetic alteration, deposits and lithofacies, as well as their control and influence on reservoir quality is still unclear. In this study, casting thin section, scanning electron microscope (SEM) and backscatter scanning electron microscope (BSE) combined with energy spectrum analysis, together with stable isotope analysis, X-ray diffraction analysis, and homogenization temperature test of fluid inclusions are used to analyze the reservoir characteristics including petrology, lithofacies, history and intensity of diagenesis. The control and influence of these characteristics on ultimate reservoir quality of digitate shallow-water lacustrine deltas are further evaluated. The results show that four lithofacies can be identified (namely, “i”, “ii”, “iii”, “iv”) with the decrease of grain size and increase of ductile components in the tight sandstones of digitate shallow-water lacustrine delta, respectively corresponding to preferential development positions in the deposits. There are similarities and differences on the diagenetic processes among various lithofacies. The strong mechanical compaction after burial primarily decrease the original pore space in all lithofacies, and the largest loss of pore space occurs in lithofacies iv sandstones (siltstone with wavy bedding). The chlorite is mainly in the morphology of pore-lining, but coating and rosette-like chlorite are rare. The ability to resist compaction in sandstones of lithofacies i and lithofacies ii is enhanced due to the moderate development of pore-lining chlorite, thus retaining partial pore space. Carbonate cements are abundant in relatively coarser-grained sandstones close to the sandstone-mudstone interface, and the occurrence of these cements is closely related to the adjacent mudstone, indicating that Fe and Mg ions necessary for carbonate cementation are most likely from adjacent mudstone where ions are released by mechanical compaction and subsequent hydrocarbon generation pressurization during the burial process. Weak carbonate cementation occasionally occurs at the architectural bounding surface far away from mudstone, which probably related to the transformation of clay minerals. Five typical diagenetic evolution patterns in digitate shallow-water lacustrine deltaic reservoir are summarized by considering the diagenetic processes with deposits and lithofacies. From pattern I to pattern V, the corresponding reservoir quality gradually deteriorates. The results in this study are of great help to deepen the understanding of diagenetic alteration process and reservoir heterogeneity of tight sandstones, and provide theoretical basis for exploration and sustainable development of similar lacustrine shallow-water lacustrine delta reservoirs, especially for bar fingers in shallow-water deltas.

Interaction of Bioactive Compounds of Moringa oleifera Leaves with SARS-CoV-2 Proteins to Combat COVID-19 Pathogenesis: a Phytochemical and In Silico Analysis.

Novel SARS-CoV-2 claimed a large number of human lives. The main proteins for viral entry into host cells are SARS-CoV-2 spike glycoprotein (PDB ID: 6VYB) and spike receptor-binding domain bound with ACE2 (spike RBD-ACE2; PDB ID: 6M0J). Currently, specific therapies are lacking globally. This study was designed to investigate the bioactive components from Moringa oleifera leaf (MOL) extract by gas chromatography-mass spectroscopy (GC–MS) and their binding interactions with spike glycoprotein and spike RBD-ACE2 protein through computational analysis. GC–MS-based analysis unveiled the presence of thirty-seven bioactive components in MOL extract, viz. polyphenols, fatty acids, terpenes/triterpenes, phytosterols/steroids, and aliphatic hydrocarbons. These bioactive phytoconstituents showed potential binding with SARS-CoV-2 spike glycoprotein and spike RBD-ACE2 protein through the AutoDock 4.2 tool. Further by using AutoDock 4.2 and AutoDock Vina, the top sixteen hits (binding energy ≥ − 6.0 kcal/mol) were selected, and these might be considered as active biomolecules. Moreover, molecular dynamics simulation was determined by the Desmond module. Interestingly two biomolecules, namely β-tocopherol with spike glycoprotein and β-sitosterol with spike RBD-ACE2, displayed the best interacting complexes and low deviations during 100-ns simulation, implying their strong stability and compactness. Remarkably, both β-tocopherol and β-sitosterol also showed the drug- likeness with no predicted toxicity. In conclusion, these findings suggested that both compounds β-tocopherol and β-sitosterol may be developed as anti-SARS-CoV-2 drugs. The current findings of in silico approach need to be optimized using in vitro and clinical studies to prove the effectiveness of phytomolecules against SARS-CoV-2.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12010-022-04040-1.

New insights into the role of system sealing capacity in shale evolution under conditions analogous to geology: Implications for nanopore evolution

Closed and semi-closed pyrolysis of a lacustrine shale sample was conducted using the same instrument characterized by lithostatic pressure and limited reactive space in order to unravel the impacts of the system sealing capacity on organic matter occurrence and nanopore development in shales under conditions analogous to natural processes. The solid residues were subjected to organic geochemical measurements, low-pressure gas (N2 and CO2) adsorption tests, and field emission-scatter electrical microscope analysis. The results revealed that solvent extraction played positive and negative roles in the pore development of solid residues from both systems at different thermal maturities. Inorganic and organic pores were primarily filled or shielded by soluble bitumen at low and high temperatures, respectively. The occurrences of organic matter in solid residues from the two systems were different at lower temperatures but gradually evolved similarly at higher temperatures and were dominated by nanoscale interparticle organic matter. Organic pore occurrence in solid residues from the two systems was approximately comparable. However, differences in pore volume and specific surface area of solid residues from the closed and semi-closed systems increased measurably below 550 °C. At 550 °C, a strong mechanical compaction and overpressure environment caused deformation and closure of pores surrounding rigid minerals and pores associated with ductile minerals surrounding organic matter in solid residue from the closed system, while only a few pores surrounding rigid minerals from the semi-closed system deformed. Consequently, similar pore parameters of solid residues from the two systems were obtained at this temperature. Additionally, the variation in organic porosity of solid residues from the two systems has obvious stages based on mass balance calculation. The organic porosity evolution is collectively affected by system sealing capacity and thermal maturity at lower matured stages. In contrast, organic porosity evolution in solid residues is independent of system sealing capacity at high- and overmatured stages. Although the depositional environment is different, this study provides direct evidence that the difference in system sealing capacity is not the predominant factor leading to different organic pore developments in the Silurian and Cambrian shales in South China.

Strong compactness and the ultrapower axiom I: the least strongly compact cardinal

The Ultrapower Axiom is a combinatorial principle concerning the structure of large cardinals that is true in all known canonical inner models of set theory. A longstanding test question for inner model theory is the equiconsistency of strongly compact and supercompact cardinals. In this paper, it is shown that under the Ultrapower Axiom, the least strongly compact cardinal is supercompact. A number of stronger results are established, setting the stage for a complete analysis of strong compactness and supercompactness under UA that will be carried out in the sequel to this paper.

Effect of Diagenesis on the Quality of Sandstone Reservoirs Exposed to High-Temperature, Overpressure, and CO2-Charging Conditions: A Case Study of Upper Miocene Huangliu Sandstones of Dongfang District, Yinggehai Basin, South China Sea

The Upper Miocene Huangliu sandstones of the Dongfang district are currently regarded as an important exploration target in the Yinggehai Basin. Affected by the anomalous diagenetic environments of high temperature, overpressure, and CO2 fillings, the diagenetic evolution of the Huangliu sandstones appear complicated characteristics and subsequently exert a significant influence on reservoir development. Integrated methods employed in this study include an electron microscope, cathode luminescence, X-ray diffraction, scanning electron microscope, electron microprobe, stable isotope analysis, homogenization temperature, and physical property tests. By the comparative researches between the AF-1 and AF-2 areas of the Dongfang district, the aim of this study is to investigate the complex diagenetic modifications and their controlling effects on reservoir quality and development mechanism. With similar sedimentary features, the reservoirs in the AF-1 area exhibit slightly higher porosity than those of the AF-2 area. The permeability in the AF-1 area shows one or two orders of magnitude lower than that of the AF-2 area, and throats size distribution act as a critical factor to cause distinct diversities of permeability. In the AF-1 area, the later appearance of overpressure contributed to stronger compaction intensity and more loss of primary porosity. The dissolution induced by CO2-rich thermal fluids in late stage enhanced the secondary porosity significantly and improved the total porosity. However, extensive dissolution cause abundant precipitation including carbonate cement and authigenic illite in a closed diagenetic system, which lead to the decrease of reservoirs’ permeability. As for the AF-2 area, earlier occurrence of overpressure restrained mechanical compaction obviously and further retarded corrosion of organic acid, which preserved high proportions of primary porosity. Due to lesser impact by CO2 filling, the AF-2 area had a poor intensity of dissolution and cementation, and the authigenic illitization was also restrained significantly, which effectively prevented heavy damage on reservoir quality, and especially for permeability. Based on the diagenetic evolution pathways, two types of porosity evolution patterns are established. The effect degree on diagenesis by high temperature, overpressure, and CO2 filling vary significantly between the AF-1 and AF-2 areas. The two areas show different pathways of diagenetic evolution, forming two development patterns and exhibiting different reservoir types.

The Role of Roller Rotation Pattern in the Spreading Process of Polymer/Short-Fiber Composite Powder in Selective Laser Sintering.

In this study, for the first time, a forward-rotating roller is proposed for the spreading of CF/PA12 composite powder in the selective laser sintering (SLS) process. The mesoscopic kinetic mechanism of composite particle spreading is investigated by utilizing the “multi-spherical” element within the discrete element method (DEM). The commercial software EDEM and the open-source DEM particle simulation code LIGGGHTS-PUBLIC are used for the simulations in this work. It is found that the forward-rotating roller produces a strong compaction on the powder pile than does the conventional counter-rotating roller, thus increasing the coordination number and mass flow rate of the particle flow, which significantly improves the powder bed quality. In addition, the forward-rotating pattern generates a braking friction force on the particles in the opposite direction to their spread, which affects the particle dynamics and deposition process. Therefore, appropriately increasing the roller rotation speed to make this force comparable to the roller dragging force could result in faster deposition of the composite particles to form a stable powder bed. This mechanism allows the forward-rotating roller to maintain a good powder bed quality, even at a high spreading speed, thus providing greater potential for the industry to improve the spreading efficiency of the SLS process.

Uniform regularity and vanishing viscosity limit for the incompressible non-resistive magneto-micropolar equations

In this paper, we consider the vanishing viscosity limit for the incompressible non-resistive magneto-micropolar equations on the half-space with no-slip boundary condition (3). We prove that the vanishing viscosity limit is uniform over a time interval, which indicates that the incompressible non-resistive magneto-micropolar equations with the no-slip boundary condition have a strong solution and the solution is uniformly bounded in both the conormal Sobolev norm and norm. As a direct result, we obtain the vanishing viscosity limit for the incompressible non-resistive magneto-micropolar equations by a strong compactness argument.

Lower limits and controlling factors of the petrophysical properties of coal-measure sandstone oil reservoirs: A case study of the Jurassic Yan’an Formation in the Huanjiang area, Ordos Basin, China

Coal-measure sandstone oil reservoirs of the Jurassic Yan’an Formation in the Ordos Basin, China, have strong heterogeneity. Reservoir quality is the core factor that determines the large-scale accumulation of hydrocarbons. Taking the Yan’an Formation in the Huanjiang area, Ordos Basin, as an example, we have calculated the lower limits of petrophysical properties based on empirical statistics, porosity and permeability intersections, mercury injections and irreducible water analysis, oil tests, oil-bearing property analysis, and distribution functions. In addition, we have investigated the main controlling factors of effective reservoirs in the Yan’an Formation. The results demonstrate that the lower limits of petrophysical properties of the effective reservoir in the Yan’an Formation display a gradually decreasing trend as the depth increases. Furthermore, we have obtained the functions of the lower limits of the petrophysical properties and the depth. Sedimentation and diagenesis have a significant control effect on the quality of reservoirs in the Yan’an Formation. High-quality reservoirs have mainly developed in the sedimentary microfacies of point sand bar and distributary channel sand bodies. The strong compaction and cementation in the diagenesis process are the internal reasons for the poor petrophysical properties of the Yan’an Formation reservoirs. Overall, the effect of compaction on the petrophysical properties of the reservoir is stronger than that of cementation, whereas the secondary dissolution pores significantly improve the petrophysical properties of the reservoir.

Diagenetic and hydrothermal fluid influence on tight sandstone reservoir quality: Gravity-flow deposits from the Huangliu Formation, Ledong area, Yinggehai Basin, South China Sea

The tight sandstone of gravity-flow deposits in Miocene Mbr 2 of the Huangliu Fm, Ledong area is one of the focuses future exploration in the Yinggehai Basin. Reservoirs have complex sedimentary and diagenesis processes, experienced multi-stage fluid influence. However, the influence of different diagenesis on reservoir quality, and distribution patterns of different diagenetic facies in Mbr 2 of the Huangliu Fm are still short in research. In this paper, a variety of methods, such as thin sections analysis, electron microscopy (SEM), electron probe micro-analyzer (EPMA), cathode luminescence (CL), x-ray diffraction measurement (XRD), in situ carbon and oxygen isotopes composition of cements (SIMS), fluid inclusion homogenization temperature, and high-pressure mercury injection (HPMI), are used to analyze reservoir quality, diagenetic evolution stages, diagenesis, fluid filling processes, etc. Studies have shown that there are obvious differences in diagenetic evolution process, including carbonate cementation, organic acid and hydrothermal dissolution, etc. Which ultimately leads to large differences in physical properties. Although sandstone texture has an impact on reservoir quality, strong compaction and early carbonate cementation were the main reasons for reservoir densification. Early calcite was precipitated in alkaline seawater, and later ferrocalcite was formed by the recrystallization of calcite and polyframboidal pyrites and euhedral pyrites formed under organic acid charged. After hydrothermal fluid charged, dolomite, iron dolomite, cement pyrites and dispersed granular pyrites precipitated. Besides, illite filled the throat. The dissolution of organic acids and late CO2-rich hydrothermal fluids improved the quality of reservoirs. According to the difference of diagenetic process and the quality of the reservoirs, Mbr 2 of the Huangliu Fm is divided into 4 types of diagenetic facies. High-quality reservoirs are mostly developed in H2-Ⅰ, H2-Ⅱ, and H2-Ⅴ sand formation near faults. Early carbonate cements were less developed, which could support primary intergranular pores. Feldspar, rock fragments, and early carbonate cements were strongly dissolved. It includes two diagenetic facies, low cementation - strong dissolution reservoirs and slightly cementation - weaken dissolution reservoirs. On the contrary, tight reservoirs mostly develop in H2-Ⅲ, H2-IV, and H2–V sand formation far away from faults, including late compacted tight reservoirs and early carbonate cementation tight reservoirs. The research results are helpful to analyze the diagenetic evolution of tight sandstone reservoirs, and conducive to the study of similar gravity-flow reservoir quality with the influence of hydrothermal fluids.

A novel wavelet decomposition and transformation convolutional neural network with data augmentation for breast cancer detection using digital mammogram

Research in deep learning (DL) has continued to provide significant solutions to the challenges of detecting breast cancer in digital images. Image preprocessing methods and architecture enhancement techniques have been proposed to improve the performance of DL models such as convolutional neural networks (CNNs). For instance, the wavelet decomposition function has been used for image feature extraction in CNNs due to its strong compactness. Additionally, CNN architectures have been optimized to improve the process of feature detection to support the classification process. However, these approaches still lack completeness, as no mechanism exists to discriminate features to be enhanced and features to be eliminated for feature enhancement. More so, no studies have approached the use of wavelet transform to restructure CNN architectures to improve the detection of discriminant features in digital mammography for increased classification accuracy. Therefore, this study addresses these problems through wavelet-CNN-wavelet architecture. The approach presented in this paper combines seam carving and wavelet decomposition algorithms for image preprocessing to find discriminative features. These features are passed as input to a CNN-wavelet structure that uses the new wavelet transformation function proposed in this paper. The CNN-wavelet architecture applied layers of wavelet transform and reduced feature maps to obtain features suggestive of abnormalities that support the classification process. Meanwhile, we synthesized image samples with architectural distortion using a generative adversarial network (GAN) model to argue for their training datasets' insufficiency. Experimentation of the proposed method was carried out using DDSM + CBIS and MIAS datasets. The results obtained showed that the new method improved the classification accuracy and lowered the loss function values. The study's findings demonstrate the usefulness of the wavelet transform function in restructuring CNN architectures for performance enhancement in detecting abnormalities leading to breast cancer in digital mammography.

Experimental study of chemical evolution and isotope fractionation of Cl and Br in pore water expelled during strong clay compaction

In sedimentary basins, clay compaction by burial can lead to fluid overpressure and is suspected to also generate fresh waters, but few geochemical tracers are available to assess this process both qualitatively and quantitatively. Our objective was to carry out experiments on the chemical - and halogen (Cl, Br) isotope evolutions of pore water expelled during clay compaction. For this, the smectite-rich bentonite MX80 and an illite-rich marl (Sainte-Suzanne) were equilibrated with ocean water. During two compaction experiments under high fluid pressure (45 MPa), mechanical stress (up to 150 MPa) and temperature (up to 150 °C), it was found that the chemistry and isotope behavior is considerably different between the swelling clay and the non-swelling clay.We saw a general decrease of the cat- and anion concentrations in the expelled water, for swelling clay while its concentration slightly increases in the remaining pore fluid. This was not the case for non-swelling clay. More freshening of the expelled water occurred during the compaction at higher temperature.We also observed a larger range of isotopic variation for Br (δ81Br from 0.9‰ up to 1.5‰) than for Cl (δ37Cl from −0.5‰ to −0.1‰) in the compaction experiments. During the compaction of illite-rich marl, no significant variation of Cl isotope (δ37Cl close to 0‰) was observed while the δ81Br value of the expelled water showed the same general increase (from 0.9‰ up to 1.5‰) as during the compaction of smectite-rich bentonite.We observed limited mineralogical transformations in terms of dissolution/precipitation processes. Therefore the surface chemistry of the clay in combination with decreasing porosity, in part, drive the anion and isotope evolution. We propose that significant retention of Cl and Br in the pore water of the compacted smectite-rich bentonite is indicative of ultrafiltration and that Cl and Br isotopes are promising tracers to consider when tracking the origin of low-salinity formation waters in sedimentary basins.