Neurocirculatory dystonia occupies a special place among the most common cardiovascular diseases. On the one hand, it is almost the most often diagnosed cardiologic ambulatory disease in young patients, on the other hand, its clinical-nosological framework and diagnostic criteria have remain not completely defined just as decades ago. One of the characteristic manifestations of neurocirculatory dystonia is a reduction in physical capacity of patients, due both to the lack of strong-willed qualities and detraining, and disorders of oxygen and hemodynamic support of physical activity. In this study, it was shown that one of the factors limiting exercise tolerance in patients with neurocirculatory dystonia, is the lack of growth of parameters of cardiac output at all levels of exercise stress. These features of hemodynamic support of physical activity were most pronounced in patients with low tolerance to the load, while in the group with high physical ability they were in limits of statistically non-significant trends. The recovery period in patients neurocirculatory dystonia was extended: heart rate, in contrast to the healthy persons, did not return to initial values even for 10 minutes. Throughout the recovery period, patients remained observed at the peak of the load relative reduction in stroke and cardiac indexes. Perhaps one of the causes of hemodynamic dysadaptation in NDC patients to physical activity and reduced physical performance is a violation of their orthostatic reactions, the lack of mechanisms that ensure adequate venous return and cardiac output. Hyper-reactivity of the cardiovascular system, manifested in a consistent trend of tachycardia and increased peripheral vascular tone, may play a compensatory role.