From 17:00 to 18:00 local standard time (LST) on 3 July 2019, a rare strong tornado occurred in Kaiyuan, Liaoning Province, northeast China. NCEP/NCAR 0.25° × 0.25° reanalysis data and WRF4.0 numerical prediction models were used to carry out the numerical simulation. Double nesting was adopted, and the horizontal grid distance was 9 km by 3 km. Based on the observation data of China meteorological observation stations, surface and upper charts, Doppler radar data, Himawari(HMW)-8 satellite images and numerical simulation results, the mesoscale structure and mechanism of the tornado were studied. The results show that: (1) At the northwest edge of the subtropical high, and the northeast cold vortex located in Northeast China, when the transverse trough moves southward, cold air is supplied continuously. Under the joint influence of the surface northeast cyclone, these are the main synoptic features of the tornado; (2) The northeast cold vortex cloud system was located at the junction of Heilongjiang and Jilin Provinces, and a squall line cloud system is formed. The tornado occurred at the tail of the squall line, and the strongest echo reached 65 dBZ. A mesocyclone, a 20 km northwest–southeast convergence belt, V-shaped gap, echo overhang structure and tornado vortex feature (TVS) were detected by the Doppler radar; (3) Before the tornado occurred, dry and cold air intruded from the northwest of the cold vortex, and a water vapor convergence zone appeared south of the squall line. The water vapor saturation zone with 80% relative humidity in northeast China was concentrated at 700 hPa, and the 20% dry column dropped down to 500 hPa between 115 and 124° E from the west. On the 850 hPa physical fields, there was a −20 × 10−5 s−1 convergence zone, and a 16 × 10−5 s−1 divergence belt appeared south and north of the squall line. A negative vorticity belt and a positive vorticity belt appeared south and north of the squall line, respectively. Kaiyuan is located at the smallest vertical shear, which is the junction place of three large vertical shear belts; (4) After 10:00 LST, the westerly wind 20 (10) m·s−1 dropped to 400 (800) hPa between 126 and 127° E. The northerly gale at 300 hPa north of 45° N moved southward. The rising center of the low level at 17:00 LST at approximately 45° N moved southward, and a sinking center appeared above it; (5) Several pairs of positive and negative vorticity columns formed between the lower troposphere and the place where the tornado occurred. There was convective instability at the lower level. CAPE increased, 0–3 km vertical wind shear increased, and LCL decreased remarkably during the afternoon.