Hashing methods have attracted much attention for large scale image retrieval. Some deep hashing methods have achieved promising results by taking advantage of the strong representation power of deep networks recently. However, existing deep hashing methods treat all hash bits equally. On one hand, a large number of images share the same distance to a query image due to the discrete Hamming distance, which raises a critical issue of image retrieval where fine-grained rankings are very important. On the other hand, different hash bits actually contribute to the image retrieval differently, and treating them equally greatly affects the retrieval accuracy of image. To address the above two problems, we propose the query-adaptive deep weighted hashing (QaDWH) approach, which can perform fine-grained ranking for different queries by weighted Hamming distance. First, a novel deep hashing network is proposed to learn the hash codes and corresponding class-wise weights jointly, so that the learned weights can reflect the importance of different hash bits for different image classes. Second, a query-adaptive image retrieval method is proposed, which rapidly generates hash bit weights for different query images by fusing its semantic probability and the learned class-wise weights. Fine-grained image retrieval is then performed by the weighted Hamming distance, which can provide more accurate ranking than the traditional Hamming distance. Experiments on four widely used datasets show that the proposed approach outperforms eight state-of-the-art hashing methods.