Strong Proof Research Articles

First Report on Bioaccessibility, Antioxidant Activity and Total Phenolic Compounds From Stachys thirkei C.Koch Using A Simulated In Vitro Digestion System

It is of great importance to determine the antioxidant properties of plants, especially those used for food, pharmacology and medicinal purposes. Stachys thirkei C.Koch belonging to Lamiaceae family is used as a medicinal aromatic plant in Turkey. The present study was carried out to investigate the total phenolic contents, antioxidant activity and bioaccessibility of S. thirkei C.Koch. The total phenolic content (TPC) was evaluated by Folin-Ciocalteu colorimetric procedure and antioxidant activity determine four distinctive methods (ABTS•+, CUPRAC, DPPH• and FRAP). According to the results, the levels of hydrolysable phenolics (1538.99±4.57 mg of GAE/100g) approximately three and a half fold higher than extractable phenolics (422.96±4.70 mg of GAE/100g). The TPC of S. thirkei C.Koch was determined to be 1961.95±4.46 mg of GAE/100g. On the other hand, the bioaccessible fractions and phenolic bioaccessibility of S. thirkei C.Koch were found to be 1766.72±2.96 μmol Trolox/g and 90.05±1.50%, respectively. At the same time, the antioxidative bioaccessibility of S. thirkei was found to be higher in FRAP method (1164.29 μmol Trolox/g) and also the bioaccessibility (%) of S. thirkei C.Koch was found to be higher in CUPRAC method (93.41%). Present study is the first report to investigate the antioxidant effect and bioaccessibility of the extracts from S. thirkei C.Koch. The results of the present study can be strong scientific proof to use this plant as a beneficial source of antioxidant referments and the studies can be further extended to investigate whether they exhibit similar activities in in vivo systems.

Efficient Error Detection Architectures for Postquantum Signature Falcon’s Sampler and KEM SABER

Among the National Institute for Standards and Technology (NIST) postquantum cryptography (PQC) standardization Round 3 finalists (announced in 2020 and anticipated to conclude in 2022–2024), SABER and Falcon are efficient key encapsulation mechanism (KEM) and compact signature scheme, respectively. SABER is a simple and flexible cryptographic scheme, highly suitable for thwarting potential attacks in the postquantum era. Implementing SABER can be performed solely in hardware (HW) or on HW/software coprocessors. On the other hand, the compact key size, efficient design, and strong reliability proof in the quantum random oracle model (QROM) make Falcon a highly suitable signature algorithm for PQC. Although Falcon is crucial as a PQC signature scheme, the utilization of the Gaussian sampler makes it vulnerable to malicious attacks, e.g., fault attacks. This is the first work to present error detection schemes embedded efficiently in SABER as well as Falcon’s sampler architectures, which can detect both transient and permanent faults. Moreover, we implement HW design for the ModFalcon signature algorithm as well as the Gaussian sampler. These schemes are implemented on a formerly Xilinx field-programmable gate array (FPGA) family, for both SABER and Falcon variants, where we assess the error coverage and the performance. The proposed schemes incur low overhead (the area, delay, and power overheads being 22.59%, 19.77%, and 10.67%, respectively, in the worst case) while providing a high fault detection rate (99.9975% in the worst case scenario), making them suitable for high efficiency and compact HW implementations of constrained applications.

Transparency of Accounting Information in the Romanian Gendarmerie

Abstract Given the current context in which, for the first time since 1945, a war is taking place in Europe between two states, right on the borders of NATO and Romania, it is very important that the specialized state institutions with military status, such as the Romanian Gendarmerie, to be efficient. The budgets allocated to the Romanian Gendarmerie exceed the amount of two billion lei annually. Analyzing the level of funding, the requirements of citizens from the Romanian Gendarmerie can be raised and they expect to benefit from a considerable level of security. The Gendarmerie has the legal obligation to make available to the citizens through the websites the information related to the financial statements. This is a strong proof of openness to the taxpayer, as he has the right to know the directions of action of public entities. The purpose of the paper is to present the importance of the Romanian Gendarmerie’s transparency towards the citizens through the accounting information. The paper also examines the procedure by which interested parts have access to the financial statements and analyzes the particularities and differences between two strategic Gendarmerie units, located in Cluj-Napoca.

THE APPLICATION OF MODERN LEGAL POSITIVISM TO THE PRINCIPLE OF LEGAL CERTAINTY IN CERTIFICATE OF PROPRIETARY RIGHTS TO LAND

Certificate of ownership of land is a strong and complete proof for everyone whose names are listed and listed in the certificate of ownership of the land. However, in reality the SHM on the land can be canceled at any time as stipulated in Article 32 of Government Regulation Number 24 of 1997 concerning Land Registration, whereas in Article 20 Paragraph (1) of Law Number 5 of 1960 concerning Agrarian Principles it is stated that property rights, namely as hereditary rights, the strongest and fullest. Thus the legal certainty of SHM on land is not absolute because the SHM on the land can be canceled at any time. It is necessary to renew the principle of negative publications with positive tendencies that do not have a strong rationale for legal certainty, justice and expediency. The problem is, how is the legal certainty of the current Land Ownership Certificate which can then be canceled after a period of five years has passed since the issuance of the certificate of title to the land through a modern legal positivism approach? and what is the solution to the cancellation of land title certificates based on the conditions of das sein and das sollen?. The research method, in this dissertation research used normative juridical research methods. The conclusion of the study, the land registration system in Indonesia adheres to a negative publication system with a positive tendency. This system basically does not provide legal certainty, let alone good legal protection for certificate holders.

Deciphering the Pharmacological Potentials of Methanol Extract of Sterculia foetida Seeds Using Experimental and Computational Approaches.

The edible herb Sterculia foetida L. has potential nutraceutical and medicinal effects. The present study is performed to assess the possible antidiabetic, neuropharmacological, and antidiarrheal activity of the methanolic extract of S. foetida seeds (MESF) through in vitro, in vivo, and in silico approaches. When compared to standard acarbose, the results of the antidiabetic study provided strong proof that the glucose level in the MESF was gradually decreased by inhibiting the function of α-amylase enzymes. The sedative potential of MESF (200 and 400 mg/kg) was determined by employing open field, hole cross, and thiopental sodium-induced sleeping time tests, which revealed significant reductions in locomotor performance and increased sleep duration following MESF treatment. In addition, mice treated with MESF exhibited superior exploration during elevated plus maze and hole board tests. MESF also showed good antidiarrheal activity in castor oil-induced diarrhea and intestinal motility tests. Previously isolated compounds (captan, 1-azuleneethanol, acetate, and tetraconazole) exhibited good binding affinity in docking studies and drug-likeliness properties in absorption, distribution, metabolism, excretion/toxicity (ADME/T), and toxicological studies. Collectively, these results indicate the bioactivity of S. foetida, which represents a potential candidate in the food and pharmaceutical industries.

Prognostic impact of FGFR2/3 alterations in patients with biliary tract cancers receiving systemic chemotherapy: the BITCOIN study

AimFGFR2 rearrangements have been identified as a novel therapeutic target of biliary tract cancer (BTC). However, reliable prevalence estimates of this molecular alteration and its prognostic role have not been fully elucidated. MethodsA retrospective mono-institutional series of 286 patients affected by locally advanced or metastatic BTC (183 intrahepatic cholangiocarcinomas, 67 extrahepatic cholangiocarcinomas, 36 gallbladder carcinomas) was profiled by means of targeted DNA/RNA next-generation sequencing, immunohistochemistry and fluorescence in situ hybridisation for FGFR2/3, ERBB2, NTRK alterations, IDH1/2 and BRAF mutations and DNA mismatch repair complex proteins alterations/microsatellite instability. ResultsFGFR2 rearrangements, amplifications and point mutations were detected in 15 (5.2%), 1 and 3 cases, respectively. FGFR3 alterations were observed in 5 (1.7%) cases. IDH1/2 were mutated in 35/223 cases (15.7%). A total of 9/258 (3.5%) and 6/260 (2.3%) BTCs had ERBB2 and BRAF gene alterations, respectively. Two cases (2/242; 0.8%) had NTRK1 amplifications but no rearrangement was found. A deficit of mismatch repair protein expression was identified in 9/237 cases (3.8%). At multivariate analysis, age, ECOG performance status, number of metastatic sites, tumour stage, FGFR2/3 alterations and IDH1/2 mutations were prognostic factors of overall survival. ConclusionsThese data provide a strong proof – challenged with a robust and detailed multivariate model – that FGFR2/3 aberrations (including FGFR2 rearrangements) and IDH1/2 mutations can be prognostic for better survival in patients with BTC . The recognition and the measurement of their prognostic impact could be of primary importance for the correct interpretation of currently available data and in the design of new therapeutic trials.

Terminal sulfur atoms formation via defect engineering strategy to promote the conversion of lithium polysulfides

The defect engineering shows great potential in boosting the conversion of lithium polysulfides intermediates for high energy density lithium-sulfur batteries (LSBs), yet the catalytic mechanisms remain unclear. Herein, the oxygen-defective Li4Ti5O12-x hollow microspheres uniformly encapsulated by N-doped carbon layer ([email protected]) is delicately designed as an intrinsically polar inorganic sulfur host for the research on the catalytic mechanism. Theoretical simulations have demonstrated that the existence of oxygen deficiencies enhances the adsorption capability of spinel Li4Ti5O12 towards soluble lithium polysulfides. Some -S-S- bonds of the Li2S6 on the defective Li4Ti5O12 surface are fractured by the strong adsorption force, which allows the inert bridging sulfur atoms to be converted into the susceptible terminal sulfur atoms, and reduces the activation energy of the polysulfide conversion in some degree. In addition, with the N-doped carbon layer, secondary hollow microspheres architecture built with primary ultrathin nanosheets provide a large amount of void space and active sites for sulfur storage, adsorption and conversion. The as-designed sulfur host exhibits a remarkable rate capability of 547 mAh g−1 at 4 C (1 C=1675 mA g−1) and an outstanding long-term cyclability (519 mAh g−1 after 1000 cycles at 3 C). Besides, a high specific capacity of 832 mAh g−1 is delivered even after 100 cycles under a high sulfur mass loading of 3.2 mg cm−2, indicating its superior electrochemical performances. This work not only provides a strong proof for the application of oxygen defect in the adsorption and catalytic conversion of lithium polysulfides, but offers a promising avenue to achieve high performance LSBs with the material design concept of incorporating oxygen-deficient spinel structure with hierarchical hollow frameworks.

The metabolome as a biomarker of aging in Drosophila melanogaster.

Many biomarkers have been shown to be associated not only with chronological age but also with functional measures of biological age. In human populations, it is difficult to show whether variation in biological age is truly predictive of life expectancy, as such research would require longitudinal studies over many years, or even decades. We followed adult cohorts of 20 Drosophila Genetic Reference Panel (DGRP) strains chosen to represent the breadth of lifespan variation, obtain estimates of lifespan, baseline mortality, and rate of aging, and associate these parameters with age‐specific functional traits including fecundity and climbing activity and with age‐specific targeted metabolomic profiles. We show that activity levels and metabolome‐wide profiles are strongly associated with age, that numerous individual metabolites show a strong association with lifespan, and that the metabolome provides a biological clock that predicts not only sample age but also future mortality rates and lifespan. This study with 20 genotypes and 87 metabolites, while relatively small in scope, establishes strong proof of principle for the fly as a powerful experimental model to test hypotheses about biomarkers and aging and provides further evidence for the potential value of metabolomic profiles as biomarkers of aging.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agronomic biofortification, is effective at alleviating selenium deficiency.Objectives: The aim of the Addressing Hidden Hunger with Agronomy (AHHA) trial was to determine whether consumption of maize flour, agronomically-biofortified with selenium, affected the serum selenium concentrations of women, and children in a rural community setting.Design: An individually-randomized, double-blind placebo-controlled trial was conducted in rural Malawi. Participants were randomly allocated in a 1:1 ratio to receive either intervention maize flour biofortified with selenium through application of selenium fertilizer, or control maize flour not biofortified with selenium. Participant households received enough flour to meet the typical consumption of all household members (330 g capita−1 day−1) for a period of 8 weeks. Baseline and endline serum selenium concentration (the primary outcome) was measured by inductively coupled plasma mass spectrometry (ICP-MS).Results: One woman of reproductive age (WRA) and one school-aged child (SAC) from each of 180 households were recruited and households were randomized to each group. The baseline demographic and socioeconomic status of participants were well-balanced between arms. No serious adverse events were reported. In the intervention arm, mean (standard deviation) serum selenium concentration increased over the intervention period from 57.6 (17.0) μg L−1 (n = 88) to 107.9 (16.4) μg L−1 (n = 88) among WRA and from 46.4 (14.8) μg L−1 (n = 86) to 97.1 (16.0) μg L−1 (n = 88) among SAC. There was no evidence of change in serum selenium concentration in the control groups.Conclusion: Consumption of maize flour biofortified through application of selenium-enriched fertilizer increased selenium status in this community providing strong proof of principle that agronomic biofortification could be an effective approach to address selenium deficiency in Malawi and similar settings.Clinical Trial Registration: http://www.isrctn.com/ISRCTN85899451, identifier: ISRCTN85899451.

What Does It Mean to Be a Catechist? The Ecclesial and Spiritual Profile of a New Ministry

What Does It Mean to Be a Catechist? The Ecclesial and Spiritual Profile of a New Ministry Bishop Dr. Franz-Peter Tebartz-van Elst (bio) When Pope Francis introduced his Motu proprio “Antiquum ministerum” to the Universal Church in May of last year, we, at the Pontifical Council for the Promotion of the New Evangelization, were aware that it would be most welcomed where a large number of catechists highlighted the Church’s vitality and their efforts to evangelize and catechize. This lay Ministry of Catechist requires an understanding of what is meant by catechesis. Our familiar word ‘echo’ is part of it and points to what catechesis is all about. The word catechesis is derived from the Greek expression “kat echein,” that is, to teach by word of mouth. Catechesis is like ‘rhythmic waves’ that touch us and make us become, in turn, ‘resonators’ for others. This is the original meaning of catechesis when used and understood in the transitive form. Later in church history, it also has been used in the intransitive form, which has emphasized the teaching of the content of catechesis. Both understandings are important. To be touched by ‘pulsating waves’ and to move others to open their hearts to the gift of faith by our personal witness is part of this ministry. Catechesis also means teaching and maturing in the faith1 by receiving knowledge so that we may not think too small of God and His grace. A faith identity assumes identification with the content of everything we believe, summarized in our creeds. The ministry of catechist entails both receiving and giving all that the faith holds within the tradition of our Church and turning always to the origin of our faith. Scripture, our living tradition, and magisterial teachings are some of the sources of our faith and catechists should be [End Page 5] immersed in their ‘undulating flow.’ These ‘solid waves’ lead catechists to a threefold awareness of their ministry. I. Catechists embrace the cross During my studies in the United States more than thirty years ago, I participated in the Rite of Election for Catechumens at the Holy Name Cathedral in Chicago. The songs of that first Sunday of Lent included one, I have never forgotten; part of its words are: “Lift high the cross/The love of Christ proclaim/Till all the world/Adore his sacred name.//Each newborn servant/Of the Crucified/Bears on the brow/The seal of him who died.” George W. Kitchin wrote this song in 1887 for the British Society for the Propagation of the Gospel in Foreign Parts. It has also been suggested that this hymn was inspired by the story of Constantine’s conversion to Christianity after seeing a cross with the inscription “In hoc signo vinces” (“in this sign you will conquer”). To accept and bear the crosses in our lives leads us to embrace the cross of the Lord Jesus Christ. The more we empathize with the sufferings around us, the closer we are to the cross of the Lord. Catechists who want to proclaim the Gospel must have touched Christ’s cross and personally bear “the seal of him who died.”2 The entire story of our faith includes the manner in which canonized saints and the “saints next door”3 have found their personal call and have identified with the cross. During the Rite of Institution in the Ministry of Catechist,4 a cross is given to each candidate. When catechists receive the crucifix during the liturgy of institution, it is a clear sign that they are called to touch the wounds of Christ. To bear a personal cross, united with the cross of Christ, enables us to carry the crosses of others. This communion makes catechists capable of witnessing, in words and in deeds, the content of our faith. “Lift high the cross” there, where life tends to pull us down, seems to be the strongest proof [End Page 6] of our confidence in the providence of the love of Christ. Bearing “on the brow the seal of him who died” inspires catechists to regard others with the eyes of Christ. This leads us to a second aspect...

Caste System in Medieval Nepal

This article attempts to explore the functioning and dynamics of the caste system that prevailed in medieval Nepal from 879 to 1768 AD. Nepal is a country which has a rich diversity of castes, languages, religions, and cultures. On the one hand, it has long been a matter of pride for Nepal to host such a diverse society and on the other hand, this very diversity has espoused various critical interpretations, particularly when it comes to ethnicity and power relations. While the ancient traditions and culture of the country continue to shape the foundation of the present Nepali society, the influence of the medieval social and caste system is still present today. Irrespective of the socioeconomic implications of the caste system in the Nepali society, what the society practiced in medieval times in terms of different cases has a strong influence on the way Nepali society functions today. Although it cannot be said that the caste system is necessary and useful in all societies, there is evidence that the system was introduced by the kings and subjects of that time to make the medieval Nepali society systematic and dignified in their own ways. Of course, society is always fluid and should continue to change. However, the fact that the medieval caste system continues to survive in today’s Nepal. It is a strong proof that great change has not taken place yet in our society. The medieval caste system is becoming the basis of human identity even today. The co-existence of a diverse group of people in Nepali society has in both way nurtured the caste system by promoting the idea that diversity is good for society and its functioning. While there has been an effect of melting pot concept owing to urbanization and population growth in recent years, the fabric of Nepali society in the medieval period demonstrates a distinct caste system brought to operation from a utilitarian motive. This article aims to analyse this very distinct feature of Nepal’s medieval society wrought in the caste system in its crude form. The article not just explores the functioning of the caste system in medieval Nepali society but also exposes how it remains intact even today. This article uses descriptive and analytical methods. In course of writing, the arguments have been made based on secondary resources.

Мініатюрні видання з фонду відділу зарубіжної україніки Національної бібліотеки України імені В. І. Вернадського як об’єкт атрибуції

The miniature editions from the fond of the Department of Foreign Uсrainica of the Institute of Bibliology of V. I. Vernadsky National Library of Ukraine which were published in the Ukrainian diaspora in the second half of the 20 century are analyzed. The motives, place and purpose of their production are established, the book description is made, the characteristic features and content of these editions are determined. Their role and purpose are revealed. The origin of the mini-books has been clarifi ed. The purpose of the publication is to determine, based on the analysis of the texts of miniature publications and other documents of the diaspora, the authenticity of their origin, causes, authors of publications in them, place and year of publication and presentation of bibliographic description. Methodology. The research is based on methodological principles related to the general scientifi c principles of historicism, scientifi c objectivity, impartiality, scientifi c reliability and comprehensiveness. Mini-books were attributed through the use of search, bibliographic and documentary methods, which made it possible to analyze the external and internal characteristics of the mini-publications, to clarify their features, conformity of the content of mini-books to the original sources from which they were reprinted. Scientifi c novelty. Based on the analysis of miniature editions, their primary sources and other thematically related literature, the appearance of history of these editions is refl ected, the ways of their attribution are established and separate mini-books are attributed, their role and purpose are determined. Prospects for further researches. Miniature publications from the fond of the Department of Foreign Uсrainica of VNLU, numbering more than a hundred documents, were analyzed selectively. The ultimate goal is to attribute all available storage units of miniature books and to acquaint the general scientifi c and readership with their content, which, in our opinion, is of great importance for the formation of collective memory, integrity of Ukrainian history and book culture. Conclusions. Miniature publications from the fond of the Department of Foreign Uсrainica have signifi cant scientifi c and source-information potential, are witnesses of their era, a strong proof of the exceptional role of the book in shaping the national consciousness and identity of the reader.

A Mixed Strategy of Higher-Order Structure for Link Prediction Problem on Bipartite Graphs

Link prediction tasks have an extremely high research value in both academic and commercial fields. As a special case, link prediction in bipartite graphs has been receiving more and more attention thanks to the great success of the recommender system in the application field, such as product recommendation in E-commerce and movie recommendation in video sites. However, the difference between bipartite and unipartite graphs makes some methods designed for the latter inapplicable to the former, so it is quite important to study link prediction methods specifically for bipartite graphs. In this paper, with the aim of better measuring the similarity between two nodes in a bipartite graph and improving link prediction performance based on that, we propose a motif-based similarity index specifically for application on bipartite graphs. Our index can be regarded as a high-order evaluation of a graph’s local structure, which concerns mainly two kinds of typical 4-motifs related to bipartite graphs. After constructing our index, we integrate it into a commonly used method to measure the connection potential between every unconnected node pair. Some of the node pairs are originally unconnected, and the others are those we select deliberately to delete their edges for subsequent testing. We make experiments on six public network datasets and the results imply that the mixture of our index with the traditional method can obtain better prediction performance w.r.t. precision, recall and AUC in most cases. This is a strong proof of the effectiveness of our exploration on motifs structure. Also, our work points out an interesting direction for key graph structure exploration in the field of link prediction.

Health Benefits of Micronutrients and Stratagies to prevent micronutrient Deficiencies

In metabolism and tissue performance, micronutrients play a key role. Sufficient amount of intake is required to maintain tissue function and metabolic processes. In those people who are extremely depleted and the possibility for complications, the clinical benefits of micronutrient supplements are more advantageous in health improvement. Zinc and vitamin A supplements have contributed to lowered diarrhoea and pneumonia in children in developing countries. In slightly malnourished children, there are some indications that micronutrient supplements have cognitive influence. In several diseases, there is strong proof of the benefit of micronutrient supplements. A well-balanced diet tends to support most of the micronutrients.

STRENGTHENING LAND REGISTRATION SYSTEM THROUGH IMPLEMENTATION OF DOMAIN APPROACH IN MANIFESTING LEGAL CERTAINTY AND COMMUNITY JUSTICE

As an implementation of welfare society, the government issued Law Number 5 of 1960 Article 19 paragraph (2) c, which provide the legal certainty of land rights for all Indonesians carried out through land registration. The land registration system adopted by Indonesia is negative land cadastre with positive tendency. The implementation of land registration provide the basis of state duty to produce land registration evidence, namely certificate, which is valid as a strong proof of rights. This certificate guarantees the correctness of physical data besides juridical data as long as it is not proven otherwise. Method: This legal research used Normative juridical method, with qualitative juridical data analysis. Results of the study: Negative land cadastre with positive tendency adopted by Indonesia currently does not guarantee legal certainty of land ownership and the community justice itself. This is indicated by the fact that there is still a phenomenon of land disputes, among the result of the issuance of overlapping. By using a legal cadastre-based domain approach, through an approach of extracting historical values of land and integrating the process of dialogue within the issuing of certificate; obtaining legal certainty and the community justice can be achieved. Conclusion: Negative land cadastre with positive tendency is still unable to manifest legal certainty of land ownership and community justice so it is appropriate that an adage states “the highest legal certainty, is the highest injustice”. Strengthening land registration system through the domain approach is an alternative option to manifest legal certainty and community justice.

271 Critical role of Aquaporin-1 and telocytes in infantile hemangioma response to propranolol beta blockade

Propranolol is currently the first-line treatment for severe infantile hemangioma (IH), the most frequent tumor in childhood. Neither the molecular mechanism of action nor the cellular target of the drug has been identified with a strong proof of concept. We showed that propranolol antitumor activity was associated with alteration of Aquaporin 1 (AQP1), a water and ion channel involved in tumor cell migration and angiogenesis. In pathological context, elevated AQP1 is involved in the development and progression of tumors and associated with poor prognosis. We developed an IH in vitro model using lesional patient-derived endothelial cells (EC), pericytes (PER) and CD34+/ PDGFR-α+ stromal cells named telocytes (TC) that we first described in IH. Thus, we investigated the role of these perivascular cells in the antiangiogenic effect of propranolol in IH and tested AQP1 as a marker and target of the beta-blockade response in IH. Immunuhistofluorescence staining revealed a unique AQP1 expression in IH-TC compared to normal dermis. IH-TC maintain high in vitro AQP1 protein levels compared to foreskin control-TC. We performed a Matrigel based tube formation assay including IH-EC, IH-PER and IH-TC, which highlights migration and cell-cell interaction alterations. This 3D model has a unique response to low doses of propranolol. Indeed 3 μM of propranolol highly decreased IH angiogenesis in our in vitro model and this effect is abolished when control foreskin-TC are used instead of IH-TC. Interestingly, the knockdown of AQP1 in IH-TC shows the same anti-angiogenic effect as propranolol and the combination is not additive. Moreover, we show that this beta-blockade downregulates AQP1 in patient derived telocytes. All together, these data suggest that IH sensitivity to propranolol rely at least in part to a cross talk between lesional vascular cells and stromal telocytes and reveal a critical role of AQP1 in this antitumor response.

Application of AI for Analysis of Parkinson’s Disease

Parkinson's disease is an issue of the central tactile framework that impacts advancement provoking shudders. The tangible cell is hurt in the frontal cortex causing dopamine levels to drop which prompts the condition. Parkinson's is a reformist ailment that causes degeneration of the frontal cortex, provoking both motor and mental issues. While Dysphonia is a voice issue that causes mandatory fits in the larynx muscle, this is one of its indications. While, Bradykinesia, which is ordinarily described as slowness of improvements, is one of the cardinal signs of Parkinson's sickness (PD). Essential clinical rating scales are used usually to measure bradykinesia in routine clinical practice albeit this kind of examination is uneven. It requires clinical investigation, and it can happen starting from the age of 6. Along these lines, this is a starter study that endeavors to recognize connections between Parkinson's contamination factors for basic unmistakable verification of the sickness. There are 1 million cases in India. It is hence reasonable to acknowledge that there is a connection between a patient's ability to talk/make and the development towards Parkinson's as these limits rot as time propels. The mark of the examination was to survey the features of the sound data and the hour of contorting drawing as an extent of bradykinesia. Henceforth to make strong proof that vocalization data and the handwriting test from a patient can assist with dissecting whether they experience the evil impacts of Parkinson's. As needs be, it is at first anticipated that there is an association between the two. We attempt to run distinctive AI classifiers on the data in wants to show up at a high consistency rate that is facilitated with a reasonable runtime. The dataset managed is procured from a new report by the journal, IEEE Transactions on Biomedical Engineering, of various limits of voice repeat. The actual assessment obtained a consistency speed of 95.58% hence we want to show up at a rate close to this or possibly to beat it.

Toward a Mobile Platform for Real-world Digital Measurement of Depression: User-Centered Design, Data Quality, and Behavioral and Clinical Modeling.

BackgroundAlthough effective mental health treatments exist, the ability to match individuals to optimal treatments is poor, and timely assessment of response is difficult. One reason for these challenges is the lack of objective measurement of psychiatric symptoms. Sensors and active tasks recorded by smartphones provide a low-burden, low-cost, and scalable way to capture real-world data from patients that could augment clinical decision-making and move the field of mental health closer to measurement-based care.ObjectiveThis study tests the feasibility of a fully remote study on individuals with self-reported depression using an Android-based smartphone app to collect subjective and objective measures associated with depression severity. The goals of this pilot study are to develop an engaging user interface for high task adherence through user-centered design; test the quality of collected data from passive sensors; start building clinically relevant behavioral measures (features) from passive sensors and active inputs; and preliminarily explore connections between these features and depression severity.MethodsA total of 600 participants were asked to download the study app to join this fully remote, observational 12-week study. The app passively collected 20 sensor data streams (eg, ambient audio level, location, and inertial measurement units), and participants were asked to complete daily survey tasks, weekly voice diaries, and the clinically validated Patient Health Questionnaire (PHQ-9) self-survey. Pairwise correlations between derived behavioral features (eg, weekly minutes spent at home) and PHQ-9 were computed. Using these behavioral features, we also constructed an elastic net penalized multivariate logistic regression model predicting depressed versus nondepressed PHQ-9 scores (ie, dichotomized PHQ-9).ResultsA total of 415 individuals logged into the app. Over the course of the 12-week study, these participants completed 83.35% (4151/4980) of the PHQ-9s. Applying data sufficiency rules for minimally necessary daily and weekly data resulted in 3779 participant-weeks of data across 384 participants. Using a subset of 34 behavioral features, we found that 11 features showed a significant (P<.001 Benjamini-Hochberg adjusted) Spearman correlation with weekly PHQ-9, including voice diary–derived word sentiment and ambient audio levels. Restricting the data to those cases in which all 34 behavioral features were present, we had available 1013 participant-weeks from 186 participants. The logistic regression model predicting depression status resulted in a 10-fold cross-validated mean area under the curve of 0.656 (SD 0.079).ConclusionsThis study finds a strong proof of concept for the use of a smartphone-based assessment of depression outcomes. Behavioral features derived from passive sensors and active tasks show promising correlations with a validated clinical measure of depression (PHQ-9). Future work is needed to increase scale that may permit the construction of more complex (eg, nonlinear) predictive models and better handle data missingness.

Archean Itabirites From Ovan, NE-Gabon: Petrography, Mineralogy And Elemental Mapping

The Archean greenstone belt called Bélinga Group was highlighted in NE-Gabon around 1960. It consists of many petrographic types such as itabirites (BIFs), ultrabasites, and amphibolites. Recent geophysical studies revealed the presence of BIFs and associated rocks at Ovan, which were linked to the Bélinga Group according to similar magnetic and some petrographic characteristics. Unfortunately, data on itabirites in respect with petrography, mineralogy and geochemistry are rare. This note aims at contributing to petrography, mineralogy and elemental mapping of Ovan itabirites on the one hand, and giving strong proofs that they belong to the Bélinga Group on the other. Field investigations bring samples from six sites around Ovan. Selected itabirites samples have been studied in petrography, mineralogy (XRD) and elemental mapping (SEM). Two (2) itabirites lithofacies are recognized: the well-banded and the massive itabirites. Mineral assemblages show principally quartz, magnetite, hematite and goethite. SEM images show euhedral to sub-euhedral grains of quartz and Fe-oxides of two types: the biggest (Fe1), seen as primary minerals within Fe-rich bands and the smallest (Fe2), as secondary minerals disseminated in the siliceous levels. Elemental mapping clearly reveals alternating Fe- and Si-rich bands with Fe-rich bands predominance. Finally, the itabirites around Ovan are sedimentary rocks essentially formed by chemical precipitation and belonging to the Bélinga Group.

Evaluating the Social Cost of Conflict between New Media and Society: The Case of Gaming Disorder in South Korea

Historically, the introduction of a new media in mass market caused a strong conflict starting from the nineteenth century popular literature, comics, rock music and film. Interestingly, these conflicts have shown similar and repeated patterns, which is now called media panic and moral regulation, and games are following this pattern. In 2019, Gaming disorder (GD) was decided to be included in the International Classification of Diseases (ICD-11), and similar conflicts on games arenow expected. However, the social cost and damage have not been fully addressed until now. Thus, this study focuses on the estimation of the social cost induced by GD for policy design and decisions in the public healthcare of South Korea. Using the contingent valuation method, a popular valuation method in econometrics for non-market goods, this study has tried to estimate the social cost induced by the introduction of GD into the public healthcare practice. Focusing on a false positive problem in the diagnosis, this study estimates that the willingness to pay for GD diagnosis for children is about KRW 152 K (USD 135). Considering the difference between the prevalence of GD (1.9%) and GD suspicion rate of children in the respondents (12.54%), the excessive medical diagnosis cost due to the false positive problem is estimated to KRW 101 billion (USD 89.6 M), which is about four times more than the annual medical cost for Attention Deficit Hyperactivity Disorder (ADHD) treatment in South Korea. Thus, strong scientific proof and a cautious policy approach on GD are needed before the inclusion of GD in the public health practice.