Strong Link Research Articles

Inhibition of palmitoyltransferase ZDHHC12 sensitizes ovarian cancer cells to cisplatin through ROS-mediated mechanisms.

Platinum-based therapies have revolutionized the treatment of high-grade serous ovarian cancer (HGSOC). However, high rates of disease recurrence and progression remain a major clinical concern. Impaired mitochondrial function and dysregulated reactive oxygen species (ROS), hallmarks of cancer, hold potential as therapeutic targets for selectively sensitizing cisplatin treatment. Here, we uncover an oncogenic role of the palmitoyltransferase ZDHHC12 in regulating mitochondrial function and ROS homeostasis in HGSOC cells. Analysis of The Cancer Genome Atlas (TCGA) ovarian cancer data revealed significantly elevated ZDHHC12 expression, demonstrating the strongest positive association with ROS pathways among all ZDHHC enzymes. Transcriptomic analysis of independent ovarian cancer datasets and the SNU119 cell model corroborated this association, highlighting a strong link between ZDHHC12 expression and signature pathways involving mitochondrial oxidative metabolism and ROS regulation. Knockdown of ZDHHC12 disrupted this association, leading to increased cellular complexity, ATP levels, mitochondrial activity, and both mitochondrial and cellular ROS. This dysregulation, achieved by the siRNA knockdown of ZDHHC12 or treatment with the general palmitoylation inhibitor 2BP or the fatty acid synthase inhibitor C75, significantly enhanced cisplatin cytotoxicity in 2D and 3D spheroid models of HGSOC through ROS-mediated mechanisms. Markedly, ZDHHC12 inhibition significantly augmented the anti-tumor activity of cisplatin in an ovarian cancer xenograft tumor model, as well as in an ascites-derived organoid line of platinum-resistant ovarian cancer. Our data suggest the potential of ZDHHC12 as a promising target to improve the outcome of HGSOCs in response to platinum-based chemotherapy.

Fairness, relationships and perceptions of police legitimacy in the context of integrated offender management

ABSTRACT Integrated Offender Management (IOM) involves the police in England and Wales working closely with other criminal justice agencies to reduce the criminal activities of prolific offenders. The work involves traditional policing methods, but also police officers engaging in meaningful rehabilitative work with IOM participants. However, there may be a tension between aspects of IOM policing and procedural justice theory. Research has shown strong links between citizens’ perceptions of fair treatment and their beliefs about police legitimacy, yet at the same time some IOM policing efforts emphasise hostile and disciplinary practices. These types of approaches can threaten police legitimacy if perceived by citizens as unfair. This paper examines the self-described experiences of people subject to IOM policing. Study findings revealed that, whilst participants viewed aspects of IOM policing as unfair, they broadly accepted the legitimacy of IOM policing. This would run counter to many of the core claims of procedural justice theory. However, one plausible explanation for this reaction lies in the dynamic nature of police legitimacy and its antecedents in IOM. In this context, perceptions of police legitimacy are more firmly grounded in the relational (treatment) dimensions of procedural fairness than in other more decision-orientated aspects of the concept. This reflects the multidimensional nature of procedural justice within which the balance shifts, depending on the criminal justice setting.

Application of UAV and ground measurements for urban vegetation cooling benefits assessment, Wilanów Palace case study

This research at the Wilanów Palace, Warsaw, assesses urban greenery’s cooling impacts in a cultural heritage site using remote sensing and on-site measurements, highlighting vegetation’s importance in urban climate control. The study combines soil temperature data, UAV thermal imagery, leaf area index (LAI), LiDAR, and NDVI analyses. Findings demonstrate a strong link between vegetation density and temperature: UAV land surface temperature (LST) ranged from 26.8° to 47.5°C, peaking at 72°C, while ground-based temperatures were between 19.5° and 29.2°C, lowest in dense vegetation areas. The statistical analysis confirmed significant temperature differences across vegetation types, with higher LAI areas showing lower temperatures. These results validate the cooling effect of dense vegetation, emphasizing green spaces’ significance in urban climate regulation within cultural heritage sites. The study informs sustainable urban design and conservation, underlining the critical role of vegetation in improving urban microclimates.

Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota.

Xiao Cheng Qi (XCQ) decoction, an ancient Chinese herbal mixture, has been used in treating slow-transit constipation (STC) for years. The underlying action mechanism in relieving the clinical symptoms is unclear. Several lines of evidence point to a strong link between constipation and gut microbiota. Short-chain fatty acids (SCFAs) and microbial metabolites have been shown to affect 5-HT synthesis by activating the GPR43 receptor localized on intestinal enterochromaffin cells, since 5-HT receptors are known to influence colonic peristalsis. The objective of this study was to evaluate the efficacy of XCQ in alleviating clinical symptoms in a mouse model of STC induced by loperamide. The application of loperamide leads to a decrease in intestinal transport and fecal water, which is used to establish the animal model of STC. In addition, the relationship between constipation and gut microbiota was determined. The herbal materials, composed of Rhei Radix et Rhizoma (Rhizomes of Rheum palmatum L., Polygonaceae) 55.2 g, Magnoliae Officinalis Cortex (Barks of Magnolia officinalis Rehd. et Wils, Magnoliaceae) 27.6 g, and Aurantii Fructus Immaturus (Fruitlet of Citrus aurantium L., Rutaceae) 36.0 g, were extracted with water to prepare the XCQ decoction. The constipated mice were induced with loperamide (10 mg/kg/day), and then treated with an oral dose of XCQ herbal extract (2.0, 4.0, and 8.0 g/kg/day) two times a day. Mosapride was administered as a positive drug. In loperamide-induced STC mice, the therapeutic parameters of XCQ-treated mice were determined, i.e., (i) symptoms of constipation, composition of gut microbiota, and amount of short-chain fatty acids in feces; (ii) plasma level of 5-HT; and (iii) expressions of the GPR43 and 5-HT4 receptor in colon. XCQ ameliorated the constipation symptoms of loperamide-induced STC mice. In gut microbiota, the treatment of XCQ in STC mice increased the relative abundances of Lactobacillus, Prevotellaceae_UCG_001, Prevotellaceae_NK3B31_group, Muribaculaceae, and Roseburia in feces and decreased the relative abundances of Desulfovibrio, Tuzzerella, and Lachnospiraceae_ NK4A136_group. The levels of SCFAs in stools from the STC group were significantly lower than those the control group, and were greatly elevated via treatment with XCQ. Compared with the STC group, XCQ increased the plasma level of 5-HT and the colonic expressions of the GPR43 and 5-HT4 receptor, significantly. The underlying mechanism of XCQ in anti-constipation could be related to the modulation of gut microbiota, the increase in SCFAs, the increase in plasma 5-HT, and the colonic expressions of the GPR43 and 5-HT4 receptor. Our results indicate that XCQ is a potent natural product that could be a therapeutic strategy for constipation.

PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.

Porcine epidemic diarrhea virus (PEDV) requires complete dependence on the metabolic system of the host cell to complete its life cycle. There is a strong link between efficient viral replication and cellular lipid synthesis. However, the mechanism by which PEDV interacts with host cells to hijack cellular lipid metabolism to promote its replication remains unclear. In this study, PEDV infection significantly enhanced the expression of lipid synthesis-related genes and increased cellular lipid accumulation. Furthermore, using liquid chromatography-tandem mass spectrometry, we identified heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) as the interacting molecule of PEDV NSP9. We demonstrated that the expression of HNRNPA3 was downregulated by PEDV-induced miR-218-5p through targeting its 3' untranslated region. Interestingly, knocking down HNRNPA3 facilitated the PEDV replication by promoting cellular lipid synthesis. We next found that the knockdown of HNRNPA3 potentiated the transcriptional activity of sterol regulatory element-binding transcription factor 1 (SREBF1) through zinc finger protein 135 (ZNF135) as well as PI3K/AKT and JNK signaling pathways. In summary, we propose a model in which PEDV downregulates HNRNPA3 expression to promote the expression and activation of SREBF1 and increase cellular lipid accumulation, providing a novel mechanism by which PEDV interacts with the host to utilize cellular lipid metabolism to promote its replication.IMPORTANCEAs the major components and structural basis of the viral replication complexes of positive-stranded RNA viruses, lipids play an essential role in viral replication. However, how PEDV manipulates host cell lipid metabolism to promote viral replication by interacting with cell proteins remains poorly understood. Here, we found that SREBF1 promotes cellular lipid synthesis, which is essential for PEDV replication. Moreover, HNRNPA3 negatively regulates SREBF1 activation and specifically reduces lipid accumulation, ultimately inhibiting PEDV dsRNA synthesis. Our study provides new insight into the mechanisms by which PEDV hijacks cell lipid metabolism to benefit viral replication, which can offer a potential target for therapeutics against PEDV infection.

Relationship between executive remuneration and performance of South African mining companies

Orientation: Managers are supposed to manage companies to maximise shareholders’ wealth. Instead, there are long-standing perceptions that managers are rent extractors who maximise their own wealth, implying a misalignment between executive remuneration and company performance.Research purpose: The purpose of this study was to determine the existence of a relationship between executive remuneration and the financial performance of South African-listed mining companies.Motivation for the study: Executive remuneration significantly increased over the past five decades relative to company financial performance. The mining sector was selected due to its susceptibility to external factors and shocks leading to volatility in the financial performance of mining companies.Research approach/design and method: This study was a quantitative archival study, using data from 2015 to 2021, by applying the hierarchical linear modelling technique at a 95% confidence level and a 5% significance level.Main findings: The study found a weak to strong relationship between executive remuneration and company financial performance. Furthermore, an analysis of executive remuneration revealed an increase in short-term incentive payments and a decrease in the fixed salary as a proportion of chief executive officer remuneration.Practical/managerial implications: Because the study found a strong link between executive remuneration and earnings-based financial performance metrics, governing bodies should ensure that financial performance metrics include cash flow-based financial metrics as company earnings are highly susceptible to management manipulation.Contribution/value-add: This study contributes to the existing literature on executive remuneration and will be useful to researchers, shareholders, boards of directors, remuneration committees and policymakers.

Deciphering the Role of ERBB3 Isoforms in Renal Cell Carcinoma: A Comprehensive Genomic and Transcriptomic Analysis.

ERBB3, a key member of the receptor tyrosine kinase family, is implicated in the progression and development of various human cancers, affecting cellular proliferation and survival. This study investigated the expression of ERBB3 isoforms in renal clear cell carcinoma (RCC), utilizing data from 538 patients from The Cancer Genome Atlas (TCGA) Firehose Legacy dataset. Employing the SUPPA2 tool, the activity of 10 ERBB3 isoforms was examined, revealing distinct expression patterns in RCC. Isoforms uc001sjg.3 and uc001sjh.3 were found to have reduced activity in tumor tissues, while uc010sqb.2 and uc001sjl.3 demonstrated increased activity. These variations in isoform expression correlate with patient survival and tumor aggressiveness, indicating their complex role in RCC. The study, further, utilizes CIBERSORTx to analyze the association between ERBB3 isoforms and immune cell profiles in the tumor microenvironment. Concurrently, Gene Set Enrichment Analysis (GSEA) was applied, establishing a strong link between elevated levels of ERBB3 isoforms and critical oncogenic pathways, including DNA repair and androgen response. RT-PCR analysis targeting the exon 21-23 and exon 23 regions of ERBB3 confirmed its heightened expression in tumor tissues, underscoring the significance of alternative splicing and exon utilization in cancer development. These findings elucidate the diverse impacts of ERBB3 isoforms on RCC, suggesting their potential as diagnostic markers and therapeutic targets. This study emphasizes the need for further exploration into the specific roles of these isoforms, which could inform more personalized and effective treatment modalities for renal clear cell carcinoma.

Infants’ pointing at nine months is associated with maternal sensitivity but not vocabulary

Infants often start pointing toward the end of their first year of life. Pointing shows a strong link to language, perhaps because parents label what infants point to. In the present study, we tested whether 9-month-olds’ pointing was related to parental sensitivity and concurrent and subsequent vocabulary scores. Observations were made of 88 9-month-old infants in free-play situations with their mothers. Less than half the infants produced at least one index-finger point. The mothers’ reactions to their infants’ behaviour were coded for sensitivity. The mothers of the infants who pointed were less directing and responded more contingently than the mothers of the infants who did not point. However, there was no difference in vocabulary scores of pointers and non-pointers, either concurrently or at 12 and 18 months of age. These results could mean that parents’ reactions play an important role in shaping pointing to be communicative.

Boundary Works as a Mechanism For Forming Collective Identity in The Indonesian Middle Class Muslim Social Piety Movement

Indonesia's title as the most generous country in the world is supported by the strengthening spirit of social piety movements among the Muslim middle class. Social piety movements are of course also supported by the power of the social movement's collective identity in forming the basis that provides the "structure," foundation for engagement, and guidance for individual participation in its expansion. Unfortunately, the strong link between the development of collective identity in social movement groups has not been explained by previous studies. The aim of this research is to describe how the boundary work mechanism contributes to the development of collective identity in the Muslim middle class social piety movement in the Tangan di Atas (TDA) community. Using qualitative descriptive research, the research was conducted over a period of one year (December 2022-December 2023) and describes the actors and boundary work mechanisms in forming collective identity. The researcher conducted in-depth interviews with several subjects who were administrators as well as members of the TDA community to explore variations in their experiences related to the social piety movement they engage in. Meanwhile, with a phenomenological approach, researchers explore the role of individual knowledge, thoughts and feelings or internal aspects or individual subjectivity. The results of this research show that there are several aspects that can be used to view boundary works as a mechanism for forming the collective identity of social piety movements in the TDA community; shared values ​​and principles, joint activities, mutual recognition and appreciation, and establishing relationships with external parties.

A network model of depressive and anxiety symptoms: a statistical evaluation.

Although network analysis studies of psychiatric syndromes have increased in recent years, most have emphasized centrality symptoms and robust edges. Broadening the focus to include bridge symptoms within a systematic review could help to elucidate symptoms having the strongest links in network models of psychiatric syndromes. We conducted this systematic review and statistical evaluation of network analyses on depressive and anxiety symptoms to identify the most central symptoms and bridge symptoms, as well as the most robust edge indices of networks. A systematic literature search was performed in PubMed, PsycINFO, Web of Science, and EMBASE databases from their inception to May 25, 2022. To determine the most influential symptoms and connections, we analyzed centrality and bridge centrality rankings and aggregated the most robust symptom connections into a summary network. After determining the most central symptoms and bridge symptoms across network models, heterogeneity across studies was examined using linear logistic regression. Thirty-three studies with 78,721 participants were included in this systematic review. Seventeen studies with 23 cross-sectional networks based on the Patient Health Questionnaire (PHQ) and Generalized Anxiety Disorder (GAD-7) assessments of clinical and community samples were examined using centrality scores. Twelve cross-sectional networks based on the PHQ and GAD-7 assessments were examined using bridge centrality scores. We found substantial variability between study samples and network features. 'Sad mood', 'Uncontrollable worry', and 'Worrying too much' were the most central symptoms, while 'Sad mood', 'Restlessness', and 'Motor disturbance' were the most frequent bridge centrality symptoms. In addition, the connection between 'Sleep' and 'Fatigue' was the most frequent edge for the depressive and anxiety symptoms network model. Central symptoms, bridge symptoms and robust edges identified in this systematic review can be viewed as potential intervention targets. We also identified gaps in the literature and future directions for network analysis of comorbid depression and anxiety.

Transactional distance theory in distance learning: Past, current, and future research trends

The accelerated adoption of distance learning in post-pandemic times has resulted in increasing research publications and review studies in a short time. This necessitates the exploration of a large corpus of academic publications for effective distance learning and learning strategies. As distance learning stakeholders have assimilated the transactional approach to understanding distance learning, transactional distance theory (TDT) is relevant to understand ways to reduce the distance between learners and educators for maximum effectiveness of distance learning. Our study applies TDT to review distance learning from a supply perspective and as a tool to ensure the improved quality of distance learning. This paper has two key contributions: we have presented evidence synthesis and conducted a foresight exercise. Following preferred reporting items for systematic reviews and meta-analyses guidelines, 275 documents published between 1994 and 2022 were identified for review. Our analysis revealed patterns, relationships, and trends in the application of TDT in various distance learning contexts. Most TDT research is conducted in social sciences (83.7%), with computer science accounting for 42.6% of the studies. The course materials’ structure and design have also received considerable attention, with around 40.0% of the research focused on this area. For distance learning, studies revolve around factors such as student engagement, satisfaction, and TDT, which examine the distance between learners and instructors in various learning environments. Through systematic review and meta-analysis, we identify the three thematic areas in TDT research on distance learning. We have chartered themes on the effect of alternate design distance learning platforms on learner success, pushing the development boundaries in distance learning success through TDT, and the practical processes for designing successful distance learning courses via TDT-based pedagogical frameworks. In doing so, we streamline research in TDT and distance learning thematically and provide insight into further work. In addition, this study analyzed the relationships between sustainable development goal (SDG) and TDT literature. The co-citation analysis suggested that the strongest links were observed between education and innovation (SDG 4 and SDG 9), followed by education and gender equality (SDG 4 and SDG 5).

From Trend to Choices: Cognitive Dissonance and Fast-Fashion Consumption Among Indonesian Influencers

In 2010, Instagram was introduced as a free photo-sharing app for iOS and Android users, providing a unique platform for sharing life experiences through visual content. This study, spanning five months (July-December 2023), explores the rise of fast fashion consumption and influencer trends in Indonesia. It employs the diffusion model proposed by Beaudoin, Moore, and Goldsmith. Analysis of interview data using NVivo highlights a strong link between the fashion industry and influencers. NVivo enables remote collaboration, allowing individuals from different locations to work on shared data files in real-time. The study emphasizes data collection through structured interviews based on an in-depth examination of influencers. Findings reveal that the high-value nature of fast fashion significantly influences Indonesian influencers, driven by the growing popularity of consumer trends and ongoing style improvements in the fashion industry. However, it emphasizes the importance of recognizing that unquestionably following trends can profoundly shape an individual's lifestyle, echoing previous research on the pivotal role of trends in fashion choices. Overall, the research underscores the substantial impact of trends and influencers on Indonesia's fast fashion landscape.

Ribāṭ in the Furthermost Coasts of Early Al-Andalus

In recent decades, the concept of ribāṭ and its practice have been the subject of intense debate. Recent summary papers on the eastern Mediterranean, Ifrīqiya, al-Maghrib al-Aqṣà, and al-Andalus, among others, have made it possible to compare different realities that express strong links with their local historical contexts. In this paper, we present the results of a new study that analyses the specific case of Northern Sharq al-Andalus, where the practice and institutionalisation of ribāṭ took shape from the early 9th century. There are three elements that lead us to corroborate this hypothesis: the documented presence of numerous individuals and groups voluntarily involved in the active and passive defence of the furthermost frontier of al-Andalus; the confirmation of a construction programme with homogeneous characteristics aimed at building fortified enclosures along the coast, and, lastly, the founding, in the early 9th century, of the Ribāṭ Kashkī centre at the mouth of the Ebro, a building were these practices would become centralised. In conclusion, we propose a much more complex scenario than that proposed previously, which enables us to characterise local forms of armed spirituality and sacralisation of the land that globally enriches the historical reading of ribāṭ.

Changes in Intestinal Flora and Serum Metabolites Pre- and Post-Antitumor Drug Therapy in Patients with Non-Small Cell Lung Cancer.

this study aimed to identify the relationships between gut microbiota, metabolism, and non-small cell lung cancer (NSCLC) treatment outcomes, which are presently unclear. in this single-center prospective cohort study, we investigated changes in the gut microbiota and serum metabolite profile in 60 patients with NSCLC after four cycles of anticancer therapy. The microbial landscape of the gut exhibited a surge in Proteobacteria and Verrucomicrobiota populations, alongside a decline in Firmicutes, Actinobacteriota, and Bacteroidota. Furthermore, a significant shift in the prevalence of certain bacterial genera was noted, with an increase in Escherichia/Shigella and Klebsiella, contrasted by a reduction in Bifidobacterium. Metabolomic analysis uncovered significant changes in lipid abundances, with certain metabolic pathways markedly altered post-treatment. Correlation assessments identified strong links between certain gut microbial genera and serum metabolite concentrations. Despite these findings, a subgroup analysis delineating patient responses to therapy revealed no significant shifts in the gut microbiome's composition after four cycles of treatment. This study emphasizes the critical role of gut microbiota changes in NSCLC patients during anticancer treatment. These insights pave the way for managing treatment complications and inform future research to improve patient care by understanding and addressing these microbiota changes.

Varying Syntax to Enhance Verb-Focused Intervention for 30-Month-Olds With Language Delay: A Concurrent Multiple Baseline Design.

The purpose of this study is to determine if 2.5-year-olds with language delay would learn verbs (spill) when presented with varying syntactic structure ("The woman is spilling the milk"/"The milk is spilling"; milk = patient or theme) in a therapeutic context. Children with language delay have proportionally small inventories of verbs, which limits expressive language development. Children who have typical language development learn verbs more robustly when presented with alternating arguments than with a single argument structure. Three toddlers with expressive language delay (29-30 months of age) participated in a verb-focused treatment study using a concurrent multiple baseline design. Participants were shown action videos accompanied by sentences with varied argument structure for each target verb. To assess learning pre- and posttreatment, participants were asked to demonstrate actions corresponding to each verb. Visual inspection and tau analyses reveal significant posttreatment gains of target verbs taught with varying argument structures. Our results indicate that learning verbs with high variability of argument roles may facilitate a strong link between lexical representations of verbs and their syntactic structures. Using argument structure variability to teach verbs as an intervention strategy has great potential and should be tested further in larger group studies.

First detection and molecular characterization of porcine reproductive and respiratory syndrome virus in Namibia, Africa.

The swine sector in Africa plays an important role in local economies, contributing to poverty alleviation and community subsistence. In addition, intensive farming is progressively becoming more important in the region. Therefore, any disease affecting swine populations can have detrimental effects on local communities. Porcine Reproductive and Respiratory Syndrome (PRRS) is among the most important infectious diseases affecting swine worldwide, but information on its epidemiology in Africa is extremely limited. In the present study, 147 healthy butchered pigs, originating from 15 Namibian intensive and rural farms were tested by RT-PCR and the ORF7 genes of positive samples were sequenced for further genetic characterization and phylogenetic analysis. Additionally, 55 warthogs were also evaluated using the same approach. Overall, 7 out of 147 pigs (4.76%) tested positive, all originating from 3 rural farms (with a within-herd detection frequency higher than 14%) characterized by strong epidemiological links. All industrial pig and warthog samples were negative. Sequence analysis revealed that all strains belonged to the Betaarterivirus suid1 species, previously known as PRRSV type I, and were likely imported from Europe at least 6 years ago, evolving independently thereafter. When and how the first introduction occurred could not be determined due to the absence of other African sequences for comparison. The present work provides the first detection and characterization of PRRSV molecular epidemiology in Namibia. Based on the present findings, the presence of the PPRSV appears marginal and limited to backyard farms. While biosecurity measures applied in industrial farms appear to be effective in preventing viral introduction, PRRSV circulation in rural settings still represents a potential threat, and considering the socio-economical implication of livestock diseases decreasing animal performances in rural areas, active monitoring should be encouraged to promptly act against emerging menaces and guarantee the welfare of local pig populations.

The trilobite assemblage of the Declivolithus Fauna (lower Katian, Ordovician) of Morocco: a review with new data

Abstract Intense commercial exploitation of fossils in the famous El Qaid Errami area in the last 20 years has led to the discovery of the interesting Declivolithus Fauna in the Moroccan Anti-Atlas. This unusually large trinucleid trilobite, described originally from the Czech Republic, is the most conspicuous element of an assemblage mainly occurring in the Bofloss locality, a local biofacies development of pelagic mudstones and sandstones cropping out in a structurally isolated place in the Tizi n'Ounfite area. Here we revise this Declivolithus Fauna trilobite assemblage from Morocco, increasing the known trilobite diversity from four to 11 species: Ulugtella? biformis n. sp., Selenopeltis cf. S. vultuosa, Phacopidina quadrata, Eudolatites cf. E. bondoni, Prionocheilus cf. P. verneuili, Nobiliasaphus cf. N. kumatox, Cyclopyge cf. C. rediviva, Symphysops stevaninae, Heterocyclopyge sp., Dionide sp., and Declivolithus alfredi. The new data and the very good preservation of specimens in sandstones, clarify the specific identity of previously reported taxa. Although the stratigraphical correlation of the fossiliferous levels remains problematic, it probably corresponds to the upper part of the Lower Ktaoua Formation or to the lower half of the Upper Tiouririne Formation. Most taxa support previous assignment of the Moroccan assemblage to the late Berounian (ca. early Katian, Ka2), although a middle Berounian (ca. Sa2–Ka1) age cannot be excluded. Most of the identified species are known from the Czech Republic (eight out of 11), showing that the strong faunal link between Morocco and the Czech Republic still existed during the Late Ordovician, being stronger than the link with the coeval Ibero-Armorican domain faunas. UUID: http://zoobank.org/3e6e55c7-168d-4008-98ba-38a795581ca3

A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities.

Osteosarcopenic obesity (OSO) represents a confluence of osteopenia/osteoporosis, sarcopenia, and obesity, contributing to increased morbidity and mortality risks. Despite escalating prevalence, its risk factors remain under-explored, necessitating this comprehensive systematic review and meta-analysis. A diligent search of PubMed, Scopus, and Cochrane databases was conducted for pertinent studies until June 2023. The random-effects model was employed to compute pooled odds ratios (ORs) and 95% confidence intervals (CIs), scrutinizing various risk factors like age, gender, lifestyle factors, and common comorbidities. Our meta-analysis incorporated 21 studies comprising 178,546 participants. We identified significant associations between OSO and factors such as female gender (OR 1.756, 95% CI 1.081 to 2.858), physical inactivity (OR 1.562, 95% CI 1.127-2.165), and hypertension (OR 1.482, 95% CI 1.207-1.821). Conversely, smoking (OR 0.854, 95% CI 0.672-1.084), alcohol consumption (OR 0.703, 95% CI 0.372-1.328), and dyslipidemia (OR 1.345, 95% CI 0.982-1.841) showed no significant associations. Remarkable heterogeneity was observed across studies, indicating considerable variation in effect sizes. Notably, OSO was strongly associated with frailty (OR 6.091; 95% CI 3.576-10.375). Our study underscored the substantial role of female gender, physical inactivity, and hypertension in the development of OSO, whilst suggesting a strong link between OSO and frailty. These findings emphasize the importance of early risk factor identification and targeted interventions in these groups. Further research is warranted to decode the complex pathophysiological interplay and devise effective prevention and management strategies.

Inferring Northern Hemisphere Continental Warming Patterns from the Amplitude and Phase of the Seasonal Cycle in Surface Temperature

Abstract The seasonal cycle in temperature is a large and well-observed response to radiative forcing, suggesting its potential as a natural analog to human-caused climate change. Although there have been advances constraining some climate feedback parameters using seasonal observations, the seasonal cycle has not been used to inform about the local temperature sensitivity to greenhouse gas forcing. In this study, we uncover a nonlinear relationship between the amplitude and phase of the seasonal cycle and forced temperature trends in seven CMIP5-era large ensembles across the Northern Hemisphere extratropical continents. We develop a mixture energy balance model that reproduces this relationship and reveals the unexpected finding that the phasing of the seasonal cycle—in addition to the amplitude—contains information about local temperature sensitivity to seasonal forcing over land. Using this energy balance model framework, we compare the pattern and magnitude of the seasonally inferred sensitivity of the surface temperature response to anthropogenic radiative forcing. The seasonally constrained model largely reproduces the pattern of human-caused temperature trends seen in climate models (r = 0.81, p value < 0.01), including polar amplification, but the magnitude of the response is smaller by about a factor of 3. Our results show the relevance of both phasing and amplitude for constraining patterns of local feedbacks and suggest the utility of additional research to better understand the differences in sensitivity between seasonal and greenhouse gas forcing. Significance Statement Warming in response to increased greenhouse gases is not spatially uniform across land. We wanted to understand whether the familiar seasonal cycle in temperature could provide information about climate change. We found that climate models show a strong link between the seasonal cycle and future warming: places with a larger and more delayed temperature response to the seasonal cycle in solar forcing tend to warm more across the Northern Hemisphere midlatitudes. A very simple model for the climate system, whose parameters are based on the seasonal cycle, captures the pattern but not the magnitude of warming. Our findings suggest that there are some similarities between the processes that control temperature change on seasonal and climate change time scales, but that we must understand the difference between seasonal and longer-term sensitivity to warming before the seasonal cycle can be used to reduce uncertainty about climate change.

A glacial lake outburst floods hazard assessment in the Patagonian Andes combining inventory data and case-studies

We present a glacial-related lake inventory for a region spanning 41.5° - 47° S in Patagonian Andes, where information on past glacier lake outburst floods (GLOF's) has hitherto remained significantly underreported. Analyzing remotely sensed images, we obtained data on 702 glacial-related lakes. Through detailed geomorphic assessments and manual supervision, we revised current inventories and added 35 GLOFs triggered from moraine/bedrock dammed lakes failures. The regional GLOF inventory presented contains information on 71 historical failures of moraine/bedrock dammed glacial lakes. From this database we analyzed outburst timing and managed to constrain 37 events occurrences within a period of 1 year. Around 40 % of them have occurred since the early 2000's, most of them originating from lakes probably formed as a delayed response to the glacial retreat imposed by the end of the Little Ice Age. On the other hand, we analyzed meteorological conditions for a sub-set of 10 events constrained within a 10-days period, finding a strong link between atmospheric rivers, cut-off lows impacting the southern Andes, and GLOFs. Only one case is likely to have been triggered by a Mw 4.9 earthquake. Based on topographic potential for avalanching, we estimated GLOF hazard potential, recognizing at least 3 subregions with high hazard, which moreover can be highly susceptible to climate conditions that regionally affect GLOF occurrence.