In order to solve the disaster caused by the instability of spatial crisscross roadways under the action of leading abutment pressure in the coal mine face, combined with a specific engineering example, the methods of theoretical analysis, numerical simulation and field measurement are adopted to simulate and analyze the stress mutual disturbance intensity and influence range of spatial crisscross roadways. The evolution law of the plastic zone in spatial crisscross roadways under the influence of mining is explored, and the key to mining instability control is made clear. The roof of the return air roadway, the shoulder angle of the two sides and the coal wall are the key parts of surrounding rock stability control. On this basis, the cooperative control scheme of changing the roadway section shape (straight wall semicircular arch), supporting (anchor cable and “U” section steel) and modifying (grouting) is put forward. Through the field measurement, within the influence range of the return air roadway, the displacement deformation of the top and bottom is less than 200 mm, which achieves the goal of roadway safety and stability. Furthermore, based on the theory of “butterfly plastic zone”, the mechanical mechanism of the overall instability of the spatial crisscross roadway is revealed; that is, during the advance of the working face, the advance mining stress is superimposed with the surrounding rock stress of the crisscross roadway, and the peak value of the partial stress of the surrounding rock mass of the crisscross roadway is increased. The expansion of the plastic zone is intensified, and beyond 7 m from the crisscross position, the shoulder angle of the two sides and the leading plastic zone of the coal wall of the working face are connected with each other, which leads to the overall failure and instability of the surrounding rock between the roadways at the intersection.