Stress Changes Research Articles

Raynaud's Phenomenon of the Nipple: Epidemiological, Clinical, Pathophysiological, and Therapeutic Characterization.

Raynaud's phenomenon of the nipple is a possible cause of pain and breastfeeding cessation in lactating women. However, there are still few studies on the characterization of this manifestation. Thus, we aim to develop a systematic review of the literature carried out between January 1992 and January 2024 in PubMed, Scopus, Web of Science, Virtual Health Library (VHL), and Portal de Periódicos da CAPES. Of the 438 articles, 19 met the eligibility criteria. The findings were divided by heuristic questions into two groups: "Epidemiological, pathophysiological, and clinical characterization of Raynaud's Phenomenon of the nipple" and "Treatment of Raynaud's Phenomenon of the nipple". Raynaud's phenomenon of the nipple is commonly primary, being more prevalent in the postpartum period, in women with a mean age of 32 years. The main triggers appear to be stress and temperature change. Generally, it is associated with a change in color and pain during breastfeeding. A calcium channel blocker was the most used medication with or without non-pharmacological measures.

Reducing Left Ventricular Wall Stress through Aortic Valve Enlargement via Transcatheter Aortic Valve Implantation in Severe Aortic Stenosis.

Background: In aortic stenosis, the left ventricle exerts additional force to pump blood through the narrowed aortic valve into the downstream arterial vasculature. Adaptive hypertrophy helps to maintain wall stress homeostasis but at the expense of impaired compliance. Advanced ventricular deformation impacts the extent of functional recovery benefits achieved through transcatheter aortic valve implantation. Methods and Results: Subgroups were stratified based on output, with low-flow severe aortic stenosis defined as stroke volume index <35 mL· m-2. Before intervention, the low-flow subgroup exhibited worse effective orifice area index and arterial and global impedance, along with thinner wall thickness and larger chamber volume marginally. LV performance, including stroke volume index, ventricular elastance, and ventricular-arterial coupling, were notably inferior, consistent with worse adverse remodeling. Although the effective orifice area index was similarly augmented after TAVI, inferior recovery benefits were noted. Persistently higher wall stress and energy consumption were observed, along with poorer ventricular-arterial coupling. These changes in wall stress showed an inverse relationship with alterations in wall thickness and were proportional to changes in dimension and volume. Additionally, they were proportional to changes in left ventricular end-systolic pressure, pressure-volume area, and ventricular-arterial coupling but inversely related to ventricular end-systolic elastance. Conclusions: The study revealed that aortic valve enlargement through transcatheter aortic valve implantation reduces left ventricular wall stress in severe aortic stenosis. The reduced recovery benefits in the low-flow subgroup were evident. Wall stress could serve as a marker of mechanical benefit after the intervention.

Study of Phase Transformations and Interface Evolution in Carbon Steel under Temperatures and Loads Using Molecular Dynamics Simulation

Carbon steel materials are widely used in mechanical transmission. Under different temperature and pressure service conditions, the microscopic changes of stress and strain that are difficult to detect and analyze by experimental means will lead to failure deformation, thus affecting their operational stability and life. In this study, the molecular dynamics method is used to simulate the heating–cooling phase transition process of common carbon steel materials. Austenite transformation temperatures of 980 K (0.2 wt.%) and 1095 K (0.5 wt.%) are acquired which is determined by the volume hysteresis before and after transformation, which is consistent with the results of JMatPro phase diagram analysis. The internal stress state of the material varies between compressive stress and tensile stress due to the change of phase structure, and the dislocation characteristics during the phase transition period are observed to change significantly. Then, an α/γ two-phase interface model is constructed to study the migration of the phase interface and the change of the phase structure by applying a continuously changing external load. At the same time, the transition pressure of α→ϵ is obtained with a value of 37 GPa under three different initial loads showing the independence of the initial load and the historical path. Based on the molecular dynamics simulation and the phase diagram calculation of the carbon steel, the analysis method for the microstructure transformation and the stress–strain behavior of the phase interface under the external load can provide a reference for the design of microstructure and mechanical properties of alloy steel in the future.

Temporal evolution of ascending aortic aneurysm wall stress predicts all-cause mortality.

Diameter-based risk stratification for elective repair of ascending aortic aneurysm fails to prevent type A dissection in many patients. Aneurysm wall stresses may contribute to risk prediction; however, rates of wall stress change over time are poorly understood. Our objective was to examine aneurysm wall stress changes over 3-5 years and subsequent all-cause mortality. Male veterans with <5.5 cm ascending aortic aneurysms and computed tomography at baseline and 3- to 5-year follow-up underwent three-dimensional aneurysm model construction. Peak circumferential and longitudinal wall stresses at systole were calculated using finite element analysis. Temporal trends were assessed by mixed-effects modelling. Changes in aortic wall stresses, diameter and length over time were evaluated as predictors of subsequent 3-year all-cause mortality by Cox proportional hazards modelling. Sixty-two male veterans were included in the study. Yearly changes in geometric and biomechanical measures were 0.12 mm/year (95% confidence interval, 0.04-0.20) for aortic diameter, 0.41 mm/year (0.12-0.71) for aortic length, 1.19 kPa/year -5.94 to 8.33) for peak circumferential stress, and 0.48 kPa/year (-3.89 to 4.84) for peak longitudinal stress. Yearly change in peak circumferential stress was significantly associated with hazard of death-hazard ratio for peak circumferential stress growth per 10 kPa/year, 1.27 (95% CI, 1.02-1.60; P = 0.037); hazard ratio for peak circumferential stress growth ≥ 32 kPa/year, 8.47 (95% CI, 2.42-30; P < 0.001). In this population of nonsurgical aneurysm patients, large temporal changes in peak circumferential stress, but not aortic diameter or length, was associated with all-cause mortality. Biomechanical stress and stress changes over time may be beneficial as additional risk factors for elective surgery in small aneurysms.

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders.

Air pollution is one of the greatest environmental risks to health, with 99% of the world's population living where the World Health Organization's air quality guidelines were not met. In addition to the respiratory and cardiovascular systems, the brain is another potential target of air pollution. Population- and experiment-based studies have shown that air pollution may affect mental health through direct or indirect biological pathways. The evidence for mental hazards associated with air pollution has been well documented. However, previous reviews mainly focused on epidemiological associations of air pollution with some specific mental disorders or possible biological mechanisms. A systematic review is absent for early effect biomarkers for characterizing mental health hazards associated with ambient air pollution, which can be used for early warning of related mental disorders and identifying susceptible populations at high risk. This review summarizes possible biomarkers involved in oxidative stress, inflammation, and epigenetic changes linking air pollution and mental disorders, as well as genetic susceptibility biomarkers. These biomarkers may provide a better understanding of air pollution's adverse effects on mental disorders and provide future research direction in this arena.

Distributed Vibration Monitoring System for 10 kV-400 kVA 3D Wound Core Transformer under Progressive Short-Circuit Impulses.

As large-scale, high-proportion, and efficient distribution transformers surge into the grids, anti-short circuit capability testing of transformer windings in efficient distribution seems necessary and prominent. To deeply explore the influence of progressively short-circuit shock impulses on the core winding deformation of efficient power transformers, a finite element theoretical model was built by referring to a three-phase three-winding 3D wound core transformer with a model of S20-MRL-400/10-NX2. The distributions of internal equivalent force and total deformation of the 3D wound core transformer along different paths under progressively short-circuit shock impulses varying from 60% to 120% were investigated. Results show that the equivalent stress and total deformation change rate reach their maximum as the short-circuit current increases from 60% to 80%, and the maximum and average variation rate for the equivalent stress reach 177.75% and 177.43%, while the maximum and average variation rate for the total deformation corresponds to 178.30% and 177.45%, respectively. Meanwhile, the maximum equivalent stress and maximum total deformation reach 29.81 MPa and 38.70 μm, respectively, as the applied short-circuit current increased to 120%. In light of the above observations, the optimization and deployment of wireless sensor nodes was suggested. Therefore, a distributed monitoring system was developed for acquiring the vibration status of the windings in a 3D wound core transformer, which is a beneficial supplement to the traditional short-circuit reactance detection methods for an efficient grid access spot-check of distribution transformers.

Numerical simulation of stress evolution and seismic moment budget along the central segments of the Xianshuihe-Xiaojiang fault system: Implications for seismic hazard assessment

The central segments of the Xianshuihe-Xiaojiang fault system (CSXXFS), which intersect densely populated areas, have remained seismically quiet without any strong earthquakes of M ≥ 7 for nearly two centuries. As such, conducting a comprehensive seismic hazard assessment of the CSXXFS serves as a crucial component of disaster mitigation efforts. To achieve this, we developed a finite element model that integrates heterogeneous mechanical properties constrained by interseismic deformation to estimate the fault locking depths within the CSXXFS. Subsequently, we performed an analysis of the seismic moment budget and Coulomb stress change to comprehensively assess the seismic hazards in the vicinity of the CSXXFS. Our findings revealed an overall average locking depth of 10 km for the Xianshuihe-Xiaojiang fault system (XXFS) and 15 km for the Daliangshan fault (DLSF). The discrepancy between the seismogenic depth and the fault locking depth indicates the presence of deep creep in certain segments of the CSXXFS. Additionally, historical earthquakes have caused stress modulation, resulting in potential earthquakes being either delayed or advanced in different segments of the CSXXFS. Specifically, the future seismic hazard is delayed in the entire Zemuhe fault (ZMHF), the northern segment of the Anninghe fault (ANHF), the southern section of the Shimian-Yuexi segment of the north Daliangshan fault (NDLSF), and the southernmost part of the south Daliangshan fault (SDLSF). Conversely, the potential earthquake on the Mianning-Xichang segment of the ANHF and the majority of the DLSF have been advanced due to positive earthquake-induced stress. Our estimation of the seismic budget suggests that the ANHF, ZMHF, NDLSF, and SDLSF have the potential to host earthquakes with magnitudes of M 6.9, M 7.3, M 7.4, and M 7.1, respectively. By adopting this integrated seismic hazard analysis, we highlight the necessity of closely evaluating potential risks and implementing appropriate mitigation strategies in this area.

Time-Series Analysis of Mining-Induced Subsidence in the Arid Region of Mongolia Based on SBAS-InSAR

Mongolia’s substantial mineral resources have played a pivotal role in its economic progress, with mining activities significantly contributing to this development. However, these continuous mining operations, particularly at the Oyu Tolgoi copper and gold mine, have induced land subsidence that threatens both production activities and poses risks of geological and other natural disasters. This study employs the Small Baseline Subset Interferometric Synthetic Aperture Radar (SBAS-InSAR) technique to monitor and analyze time-series surface subsidence using 120 Sentinel-1A datasets from 2018 to 2022. The findings reveal that the SBAS-InSAR method successfully captures the subsidence and its spatial distribution at Oyu Tolgoi, with the maximum cumulative subsidence reaching −742.01 mm and the highest annual average subsidence rate at −158.11 mm/year. Key drivers identified for the subsidence include variations in groundwater levels, active mining operations, and changes in surface stress. This research underscores the ongoing subsidence issue at the Oyu Tolgoi mining area, providing crucial insights that could aid in enhancing mining safety and environmental conservation in the region.

Effect of magnetic needle magnetic particle grinding process on the performance of metal aluminum plates

Magnetic needle grinding processing technology is one of the magnetic grinding processing techniques. It possesses the characteristics of micro-cutting removal, small increase in processing temperature, flexible processing, high-quality, and high-precision processing. It is mainly utilized to remove burrs at the edge of the workpiece and the edge of the hole, as well as to finish the surface of the workpiece. It is frequently employed in civil, aerospace, navigation, and other fields. Due to the randomness and complexity of magnetic needle movement in magnetic abrasive finishing, it is difficult to quantify the processing parameters and predict processing effects. Therefore, this paper establishes a simulation model of magnetic needle in magnetic abrasive finishing by the coupling numerical simulation method of fluid dynamics discrete element method (CFD-DEM) to analyze the working state parameters of the magnetic needle. Through the simulation of actual working conditions, the machining process and parameters of magnetic abrasive finishing are quantified and analyzed, and the motion trend of magnetic needles during the machining process is studied. Then, the residual stress of single magnetic needle impact is analyzed with ABAQUS, and the performance enhancement of the workpiece is predicted. Finally, observations of surface morphology and validation of residual stress prediction were conducted through experiments on an aluminum plate. The results show that the residual stress of the aluminum plate is positively correlated with the number of strikes of the magnetic needle. The residual stress changes from tensile stress (+0.1 MPa) to compressive stress (-16.5 MPa). The comparison between simulation results and experimental results is good, indicating that the simulation model can comprehensively consider multiple factors such as magnetic field, particle motion, and fluid flow, and establish a magnetic needle magnetic grinding process model that is suitable for actual working conditions.

Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight

As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins. While >93% of differentially abundant proteins (DAPs) in vesicles and metabolites recovered within six months, the majority (73%) of plasma DAPs were still perturbed post-flight. Moreover, these proteomic alterations correlated better with peripheral blood mononuclear cells than whole blood, suggesting that immune cells contribute more DAPs than erythrocytes. Finally, to discern possible mechanisms leading to brain-enriched protein detection and blood-brain barrier (BBB) disruption, we examined protein changes in dissected brains of spaceflight mice, which showed increases in PECAM-1, a marker of BBB integrity. These data highlight how even short-duration spaceflight can disrupt human and murine physiology and identify spaceflight biomarkers that can guide countermeasure development.

Ramp-Flat and Splay Faulting Illuminated by Frictional Afterslip Following the 2017 Mw 7.3 Sarpol-e Zahab Earthquake

Abstract As the largest instrumentally recorded earthquake in the fold-and-thrust belt of the northwestern Zagros mountain so far, the fault structure of the 2017 Mw 7.3 Sarpol-e Zahab earthquake and its contribution to regional crustal shortening remain controversial. Here, we utilize the integration of Interferometric Synthetic Aperture Radar observations and 2D finite element models incorporating various fault geometries such as planar faults, ramp-flat faults, and the combined models of ramp-flat and splay faults to explore frictional afterslip process due to coseismic stress changes following the mainshock. Our findings suggest that a ramp-flat frictional afterslip model, characterized by the maximum afterslip of ∼1.0 m and frictional variations (Δμ) of ∼0.001 and ∼0.0002 for the up-dip and down-dip portions, respectively, better explains the long-wavelength postseismic deformation than planar fault models. However, an integration model of a ramp-flat and a splay fault further improves the model fit, although the splay fault’s frictional slip is limited to &amp;lt;0.2 m, which is much smaller than that on the ramp-flat part (∼0.9 m). Considering the relocated aftershocks and structural cross-sections, the combined model could be best attributed to fault slip on the blind Mountain Front fault. Our findings thus suggest the complexity of the fault interactions between the basement and sedimentary cover in the Zagros, and that this largest basement-involved event in the region contributes to both thick- and thin-skinned shortening via seismic and aseismic behaviors, respectively.

Three-Dimensional Thermo-Chemo-Mechanical Coupled Curing Analysis for the Filament Wound Composite Shell.

Carbon fiber resin-based composite materials are widely employed in the manufacturing of composite shells. During the curing process, the temperature gradients and cure degree gradients make it easy to generate thermal strains in both carbon fibers and resin, with the resin experiencing cure shrinkage strain due to the curing reaction, ultimately leading to residual stresses and strains. In this paper, a three-dimensional thermo-chemo-mechanical coupled curing model of the composite shell was established based on a resin test, and the changes of temperature, curing degree, residual stress, and strain during the solidification of the composite shell were investigated. First, the curing property parameters and elastic modulus of HCM-2184 resin were obtained through a curing dynamic test and a tensile test. Then, considering the heat release and shrinkage reaction of solidification, a coupled thermo-chemo-mechanical curing model was developed with the CHILE (α) elastic model, and the curing process of the composite shell was simulated numerically. The results show that the resin used in the test belongs to the autocatalytic reaction. For thin composite shells, the heat accumulation inside the shell during curing is not obvious. During the curing process, the curing shrinkage behavior of the resin is an important factor for the generation of residual stress and residual strain.

Heat stress in symbiotic dinoflagellates: Implications on oxidative stress and cellular changes

Global warming has been shown to harmfully affect symbiosis between Symbiodiniaceae and other marine invertebrates. When symbiotic dinoflagellates (the genus Breviolum) were in vitro exposed to acute heat stress of +7 °C for a period of 5 days, the results revealed the negative impact on all physiological and other cellular parameters measured. Elevated temperatures resulted in a severe reduction in algal density of up to 9.5-fold, as well as pigment concentrations, indicating the status of the physiological stress and early signs of photo-bleaching. Reactive oxygen species (ROS) were increased in all heated dinoflagellate cells, while the antioxidant-reduced glutathione levels initially dropped on day one but increased under prolonged temperature stress. The cell viability parameters were reduced by 97 % over the heating period, with an increased proportion of apoptotic and necrotic cells. Autofluorescence (AF) for Cy5-PE 660-20 was reduced from 1.7-fold at day 1 to up to 50-fold drop at the end of heating time, indicating that the AF changes were highly sensitive to heat stress and that it could be an extremely sensitive tool for assessing the functionality of algal photosynthetic machinery. The addition of the drug 5-AZA-2′-deoxycytidine (5-AZA), which inhibits DNA methylation processes, was assessed in parallel and contributed to some alterations in algal cellular stress response. The presence of drug 5-AZA combined with the temperature stress had an additional impact on Symbiodiniaceae density and cell complexity, including the AF levels. These variations in cellular stress response under heat stress and compromised DNA methylation conditions may indicate the importance of this epigenetic mechanism for symbiotic dinoflagellate thermal tolerance adaptability over a longer period, which needs further exploration. Consequently, the increased ROS levels and changes in AF signals reported during ongoing heat stress in dinoflagellate cells could be used as early stress biomarkers in these microalgae and potentially other photosynthetic species.

Effect of different ulnar osteotomies on loading of the distal radioulnar joint: a finite element analysis

BackgroundUlnar impingement syndrome is a prevalent source of ulnar carpal pain; however, there is ongoing debate regarding the specific location of shortening, the method of osteotomy, the extent of shortening, and the resulting biomechanical alterations.MethodTo investigate the biomechanical changes in the distal radioulnar joint (DRUJ) resulting from different osteotomy methods, a cadaveric specimen was dissected, and the presence of a stable DRUJ structure was confirmed. Subsequently, three-dimensional data of the specimen were obtained using a CT scan, and finite element analysis was conducted after additional processing.ResultsThe DRUJ stress did not change significantly at the metaphyseal osteotomy of 2–3 mm but increased significantly when the osteotomy length reached 5 mm. When the osteotomy was performed at the diaphysis, the DRUJ stress increased with the osteotomy length, and the increase was greater than that of metaphyseal osteotomy. Stress on the DRUJ significantly increases when the position is changed to pronation dorsi-extension. Similarly, the increase in stress in diaphyseal osteotomy was greater than that in metaphyseal osteotomy. When the model was subjected to a longitudinal load of 100 N, neither osteotomy showed a significant change in DRUJ stress at the neutral position. However, the 100 N load significantly increased stress on the DRUJ when the position was changed to pronation dorsi-extension, and the diaphyseal osteotomy significantly increased stress on the DRUJ.ConclusionsFor patients with distal oblique bundle, metaphyseal osteotomy result in a lower increase in intra-articular pressure in the DRUJ compared to diaphyseal osteotomy. However, it is crucial to note that regardless of the specific type of osteotomy employed, it is advisable to avoid a shortening length exceeding 5 mm.

Mechanical properties of steel fiber reinforced recycled concrete under compression-shear stress state

The continuous urbanization of construction has led to an increasing demand for concrete, resulting in large-scale gravel and river sand mining, which seriously affect the sustainable development of the environment. The waste concrete produced by the demolition of old buildings is processed into recycled aggregate to replace natural aggregate, and then the preparation of recycled concrete can effectively alleviate this problem. This paper investigates the mechanical properties of steel fiber reinforced recycled concrete (SFRRAC) under compression shear conditions, a compression shear test with 99 cubic specimens was designed, with the variation parameters being recycled aggregate concrete replacement rate, compressive stress, and steel fiber content. The failure mode of SFRRAC under compression-shear stress was observed, and the shear force-displacement curve was calculated. Furthermore, a thorough examination was performed to assess the mechanical characteristics of SFRRAC specimens under compression-shear stress. The findings of this study suggest that as the compressive stress increases, the failure characteristics of the specimens shift from exhibiting brittle failure to displaying ductile failure. The shear strength is most sensitive to the change in compressive stress. When the compressive stress reaches 6 MPa, the shear strength can reach 3.41 times that of the direct shear specimen. The shear strength of SFRRAC specimens is composed of the bond strength of concrete, shear expansion strength, and friction shear strength. The incorporation of steel fibers can modify the distribution of shear strength among the individual components. The adverse effect of the recycled aggregate replacement rate on the toughness index of the specimen is mainly concentrated after the peak point. Nevertheless, an elevation in compressive stress and the inclusion of steel fibers can counterbalance this detrimental influence. The shear strength calculation formula of SFRRAC in shear state is put forward, which has a reference value. This study provides an experimental reference and a theoretical basis for further examination of SFRRAC.

Capacitance-based structural self-sensing of stress: effect of water/cement

The compressive stress self-sensing properties of mortars with different water-cement ratios are investigated without the need for any conductive additives. Mortar specimens are cyclically loaded and the corresponding capacitance and resistance are measured. The aluminum foil that is used as the electrode is wrapped around the prismatic sample. A coplanar configuration of electrodes is used. Capacitance and resistance increase with increasing water/cement (W/C) ratio. Stress causes decrease in capacitance and increase in resistance. The relationship between stress and fractional capacitance-resistance (except for the sample with 0.30 W C−1 ratio) change is reasonably consistent. The effectiveness of stress sensing (the fractional change in capacitance-resistance per unit of stress) decreases monotonically as the maximum stress increases, regardless of the W/C ratio. It is found that the dependence of the effectiveness of the stress sensing on the W/C ratio decreases with an increase in the maximum stress.

Acoustic Characterization of Integrated Circuits During Operation

Abstract Power electronics are widely serving as core components of propulsion systems in electric vertical takeoff and landing (VTOL) aircraft. Nevertheless, affected by the Paschen effect, the breakdown voltage of these electronics during flight is significantly lower than that on the ground, which could deteriorate system stability, or even cause aircraft faults or crashes, increasing safety risks for the public. As such, condition monitoring of power electronics has become critical for the safe operation of eVTOL. To achieve non-intrusive monitoring, acoustic emissions (AE) sensors have gained traction with their prominent resistance to electromagnetic interference and high temperatures. However, existing studies yield conflicting results regarding whether an increase in loading voltage impacts the internal mechanical stress of electronics. To address this issue, we present this work to probe the existence and the pattern of a relationship between load voltage and stress wave, since the change of mechanical stress could generate acoustic waves that can be acquired by AE sensors. In this study, an AE sensor was applied onto an oscillator placed upon an epoxy substrate to characterize the acoustic waves emitted from the device under various input loads. In the experiment, we observed a unique AE signal pattern characterized by two distinct components that consistently intersect at a specific frequency. The time required to establish such intersections progressively lengthens as the load voltage increases. Through time-domain and frequency-domain analyses of the unique AE signals under different load voltages, it was discovered that certain features of the unique AE signals have an approximately linear relationship with the load voltage.

Local relaxation of residual stress in high-strength steel welded joints treated by HFMI

This research studies the influence of high-peak loads on local relaxation of residual stress and fatigue damage in high-strength steel welded joints treated by high-frequency mechanical impact (HFMI) treatment. The joint behavior is simulated with elastic–plastic finite element analyses that account for the combined effect of geometry, residual stress, and material properties. This simulation uses two treated geometry models: with or without surface roughness on HFMI groove, and two material properties: S690QL and AH36 structural steels. The results show that surface roughness and load history, including high-peak loads, significantly influence fatigue response. It is revealed that the model neglecting the surface roughness cannot represent the amount of residual stress change and fatigue damage at less than 100 µm depth from the surface. In addition, the local yield strength in the HFMI-treated zone affects the plasticity behavior near the surface imperfection under the high-peak loads, which provides comparatively different fatigue damage between S690QL and AH36 in some cases. As a result, this study provides the further understanding needed to develop a robust modeling approach to the fatigue life estimation of HFMI-treated welds subjected to high-peak loads.

Coseismic deformation and fault slip distribution of the 2023 MW7.8 and MW7.6 earthquakes in Türkiye

On February 6, 2023, a devastating earthquake with a moment magnitude of MW7.8 struck the town of Pazarcik in south-central Türkiye, followed by another powerful earthquake with a moment magnitude of MW7.6 that struck the nearby city of Elbistan 9 h later. To study the characteristics of surface deformation caused by this event and the influence of fault rupture, this study calculated the static coseismic deformation of 56 stations and dynamic displacement waveforms of 15 stations using data from the Turkish national fixed global navigation satellite system (GNSS) network. A maximum static coseismic displacement of 0.38 m for the MW7.8 Kahramanmaras earthquake was observed at station ANTE, 36 km from the epicenter, and a maximum dynamic coseismic displacement of 4.4 m for the MW7.6 Elbistan earthquake was observed at station EKZ1, 5 km from the epicenter. The rupture-slip distributions of the two earthquakes were inverted using GNSS coseismic deformation as a constraint. The results showed that the Kahramanmaras earthquake rupture segment was distinct and exposed on the ground, resulting in significant rupture slip along the Amanos and Pazarcik fault segments of the East Anatolian Fault. The maximum slip in the Pazarcik fault segment was 10.7 m, and rupture occurred at depths of 0–15 km. In the Cardak fault region, the Elbistan earthquake caused significant ruptures at depths of 0–12 km, with the largest amount of slip reaching 11.6 m. The Coulomb stress change caused by the Kahramanmaras earthquake rupture along the Cardak fault segment was approximately 2 bars, and the area of increased Coulomb stress corresponded to the subsequent rupture region of the MW7.6 earthquake. Thus, it is likely that the MW7.8 earthquake triggered or promoted the MW7.6 earthquake. Based on the cumulative stress impact of the MW7.8 and MW7.6 events, the southwestern segment of the East Anatolian Fault, specifically the Amanos fault segment, experienced a Coulomb rupture stress change exceeding 2 bars, warranting further attention to assess its future seismic hazard risk.

Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis.

This study aimed to investigate the changes in oxidative stress, adenosine monophosphate-activated protein kinase (AMPK), connexin43 (Cx43), nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression, and extracellular matrix (ECM) in the gastric smooth muscle tissues of rats with diabetic gastroparesis (DGP) and high glucose-cultured gastric smooth muscle cells, determine the existence of oxidative stress-AMPK-Cx43-NLRP3 pathway under high glucose condition, and the involvement of this pathway in ECM remodeling in DGP rats. The results showed that with increasing duration of diabetes, oxidation stress levels gradually increased, the AMPK activity decreased first and then increased, NLRP3, CX43 expression, and membrane/cytoplasmratio of Cx43 expression were increased in the gastric smooth muscle tissues of diabetic rats. Changes in ECM of gastric smooth muscle cells wereobserved in DGP rats. The DGP group showed higher collagen type I content, increased expression of Caspase-1, transforming growth factor-beta 3 (TGF-β3), and matrix metalloproteinase-2 (MMP-2), decreased tissue inhibitor of metalloproteinase-1 (TIMP-1) expression, and higher interleukin-1betacontent when compared with the control group. For gastric smooth muscle cells cultured under higher glucose, the MMP-2 and TGF-β3 expression wasdecreased, TGF-β1 and TIMP-1 expression was increased, the interleukin-1betacontent was decreased in cells after inhibition of NLRP3 expression; the NLRP3 and Caspase-1expression was decreased, and adenosine triphosphate content was lower after inhibition of Cx43; the expression of NLRP3, Caspase-1, P2X7, and the membrane/cytoplasm ratio of CX43 expression was decreased in cells after inhibition of AMPK and oxidative stress, the phospho-AMPK expression was also decreased after suppressing oxidative stress. Our findings suggest that high glucose induced the activation of the AMPK-Cx43-NLRP3 pathway through oxidative stress, and this pathway was involved in the ECM remodeling of gastric smooth muscles in DGP rats by regulating the biological functions of TGF-β3, TGF-β1, MMP-2, and TIMP-1.