Inclusions are often present in rock defects, which can compensate for some of the problems of low rock strength and poor stability caused by hole defects. Specimens containing inclusions exhibit different mechanical properties under dynamic loading, and the strength change, energy evolution law and fracture mechanism deserve to be clearly discussed. In this work, a dynamic impact test of sandstone with circular inclusions was carried out. The failure process of each sample was recorded by a high-speed camera, and the influences of the inclusion strength and strain rate on the dynamic impact performance of the sandstone were analysed. Increasing the strain rate and inclusion strength can significantly improve the dynamic compressive strength of a sample. The dissipated energy density and impact toughness index are positively correlated with the strain rate. The dissipated energy density increased the most when the sample type was FA, at 10.6%. When the sample type was FD, the impact toughness index increased the most, which was 49.1%. In the early stage of loading, the localized strain is mainly concentrated inside the filler and gradually evolves into deformation of the filler and extension of shear cracks in the late stage of loading. The failure modes of a sample are not the result of a single factor but are influenced by both the strain rate and the filler. The types of cracks in the samples are mainly shear cracks and shear–tension composite cracks.