Advancements in analytical tools have facilitated numerous studies on perceived street quality. However, most have focused on limited aspects of street quality, failing to capture a comprehensive perception. This study introduces a quantitative approach to holistically measure street quality by integrating three key dimensions: visual perception, network accessibility, and functional diversity. Using Beijing and Shanghai as case studies, we employed artificial neural networks to analyze street view images and quantify the visual characteristics of streets. Additionally, street network accessibility was assessed through spatial design network analysis, and functional diversity was evaluated using the entropy of points of interest (POIs) data. The evaluation results were combined using the analytic hierarchy process. The reliability and accuracy of this method were validated through further testing. Our approach offers a human-centered, large-scale measurement framework, providing valuable insights for urban street renewal and design.