A field experiment was conduct during the winter (rabi) season of 2010-2011 on silty loam soil at Faizabad (Uttar Pradesh), India to develop suitable dose of customized fertilizers (CF) and moisture regime for wheat (Triticum aestivum L.) crop. Productivity of grain and straw of wheat increased with increasing level of nutrient. Highest grain yield (53.13 q ha-1) was recorded under the application of CF 12 : 30 : 16 : 0.5 : 0 : 5 (NPK 150 : 75 : 40) which was accounted increases of 18.22%, 14.55% and 10.88% more yield than F1, F4 and F6 treatment respectively. Highest water use efficiency was recorded with 6 cm irrigation at 0.8 IW/CPE ratio and customize fertilizer 12: 30: 16: 0.5: 0: 5(NPK 150: 75: 40). The highest net returns (Rs. 61324 ha-1) and B:C (2.29) were recorded under the treatment combination of 1.0 IW/CPE ratio + customize fertilizer 12: 30: 16: 0.5: 0: 5 (NPK 150: 75: 40). The increased dose of fertilization in the form of CF with proper irrigation scheduling in wheat has a high scope for the maximization of yield as well as profitability in wheat growing regions of Uttar Pradesh.