Design Strategies Research Articles

London's Strand: From Pedestrianisation to Humanisation

When busy urban areas are pedestrianised, the relationship these places have with those using them changes. Most obvious is the topographical increase in the availability of space for those traversing it on foot or bicycle. Nevertheless, there are more subtle changes as well. Regular users of pedestrianised spaces begin to forge routes, habits and responses, shaping the way the (newly) available space is used in practice. In this paper, we describe a project at King's College London which sought to explore this in the context of the newly pedestrianised area of the Strand, one of Central London’s main thoroughfares, which abuts KCL’s campus estate. We used methods drawn from deep mapping combined with quantitative and qualitative observations of research participants' walking experiences. Through GPS traces of their walking routes and qualitative interviews, we focused on understanding the benefits of pedestrianisation, the impact of new street furniture on pedestrian habits, and the transformation of the space into an area for both dwelling and traversing. Such spaces give rise to conceptual and intangible "labyrinths" constructed and mediated through people's individual experiences and through digital locative media. This study demonstrates the potential of the deep mapping paradigm in enhancing our understanding of the pedestrian walking experience in newly pedestrianised areas such as the Strand. We show how deep mapping can support spatial analysis and contribute to developing a comprehensive research and design strategy for urban areas by integrating geospatial technologies and participatory research methods.

Ligand-Shell Cooperativity in a Bilayer Silica-Sandwiched Mixed-Metals Nanocatalyst Design for Absolute Selectivity Switch.

Unlike homogeneous metal complexes, achieving absolute control over reaction selectivity in heterogeneous catalysts remains a formidable challenge due to the unguided molecular adsorption/desorption on metal-surface sites. Conventional organic surface modifiers or ligands and rigid inorganic and metal-organic porous shells are not fully effective. Here, we introduce the concept of "ligand-porous shell cooperativity" to desirably switch reaction selectivity in heterogeneous catalysis. We present a nanocatalyst design strategy consisting of bilayer silica-sandwiched 2D mixed metal islands. The intimate 2D/2D nanoscale interfacing between porous silica layers and flat island-like mixed-metal sites, combined with organic ligands, creates a nanoconfined microenvironment that enables reliable control of molecular orientation-dependent reactivity, affording the desired product in 100% selectivity. This design simultaneously leverages the hydrophobicity and flexibility of organic ligands and the nanoscale geometric rigidity of the pores inside the inorganic silica shell. Our strategy is effective with simple amorphous silica, random Cu-alloy, and commonly used metal-coordinating ligands. We demonstrate the applicability in industrially significant reactions: selective hydrogenation of alkynes, α,β-unsaturated esters/aldehydes, and nitroarenes. Our findings offer the valuable scope of a multicomponent compact nanoscale design strategy in next-generation switchable, sustainable, and recyclable catalysis.

Methyl side-groups control the Ia3̄d phase in core-non-symmetric aryloyl-hydrazine-based molecules.

Control of the formation of liquid crystalline Ia3̄d gyroid phases and their nanostructures is critical to advance materials chemistry based on the structural feature of three-dimensional helical networks. Here, we present that introducing methyl side-group(s) and slight non-symmetry into aryloyl-hydrazine-based molecules is unexpectedly crucial for their formation and can be a new design strategy through tuning intermolecular interactions: the two chemical modifications in the core portion of the chain-core-chain type molecules effectively lower and extend the Ia3̄d phase temperature ranges with the increased twist angle between neighboring molecules along the network. The detailed analyses of the aggregation structure revealed the change in the core assembly mode from the double-layered core mode of the mother molecule (without methyl groups) to the single-layered core mode. Such changes are explained in terms of modified intermolecular interactions in those phases employing quantum chemical calculations.

Dynamic regulation of ferroelectric polarization using external stimuli for efficient water splitting and beyond.

Establishing and regulating the ferroelectric polarization in ferroelectric nano-scale catalysts has been recognized as an emerging strategy to advance water splitting reactions, with the merits of improved surface charge density, high charge transfer rate, increased electronic conductivity, the creation of real active sites, and optimizing the chemisorption energy. As a result, engineering and tailoring the ferroelectric polarization induced internal electric field provides significant opportunities to improve the surface and electronic characteristics of catalysts, thereby enhancing the water splitting reaction kinetics. In this review, an interdisciplinary and comprehensive summary of recent advancements in the construction, characterization, engineering and regulation of the polarization in ferroelectric-based catalysts for water splitting is provided, by exploiting a variety of external stimuli. This review begins with a detailed overview of the classification, benefits, and identification methodologies of the ferroelectric polarization induced internal electric field; this offers significant insights for an in-depth analysis of ferroelectric-based catalysts. Subsequently, we explore the underlying structure-activity relationships for regulating the ferroelectric polarization using a range of external stimuli which include mechanical, magnetic, and thermal fields to achieve efficient water splitting, along with a combination of two or more fields. The review then highlights emerging strategies for multi-scale design and theoretical prediction of the relevant factors to develop highly promising ferroelectric catalysts for efficient water splitting. Finally, we present the challenges and perspectives on the potential research avenues in this fascinating and new field. This review therefore delivers an in-depth examination of the strategies to engineer the ferroelectric polarization for the next-generation of water electrolysis devices, systems and beyond.

Soluble Covalent Organic Frameworks as Efficient Lithiophilic Modulator for High-Performance Lithium Metal Batteries.

Lithium metal batteries (LMBs) are regarded as the potential alternative of lithium-ion batteries due to their ultrahigh theoretical specific capacity (3860 mAh g-1). However, severe instability and safety problems caused by the dendrite growth and inevitable side reactions have hindered the commercialization of LMBs. To solve them, in this contribution, a design strategy of soluble lithiophilic covalent organic frameworks (COFs) is proposed. By introducing polyethylene glycol as the side chains, two COFs (CityU-28 and CityU-29) not only become soluble for the facile spin-coating technique, but also can facilitate the lithium-ion migration in batteries. Furthermore, when coated on the lithium anode of LMB, both COFs can act as artificial solid electrolyte interphase to prevent dendrite growth thus enabling the long-term stability of the cells. Notably, the symmetric CityU-29@Li cell can work for more than 5000 h at a current density of 2 mA cm-2 and an areal capacity of 1 mAh cm-2. A remarkable capacity retention of 78.9% after 1500 cycles and a Coulombic efficiency of about 99.9% at 1.0 C can also be realized in CityU-29@Li||LiFePO4 full cell. This work could provide a universal design strategy for soluble COFs and enlighten their application in diverse scenarios, especially energy-related fields.

Design Strategy of PepNzymes-SH for an Emerging Catalyst with Serine Hydrolase-Like Functionality.

Serine hydrolases, as a class of green catalysts with hydrolytic and dehydrating activities, hold significant application value in the fields of biosynthesis and organic synthesis. However, practical applications face numerous challenges, including maintaining enzyme stability and managing usage costs. PepNzymes-SH, an emerging green catalytic material with enzyme-like activity, overcomes the operational limitations of natural enzymes and holds great promise as a substitute for hydrolases. Unfortunately, a systematic review of the design strategies for PepNzymes-SH is currently lacking. The core significance of this report lies in providing researchers with a comprehensive understanding and theoretical guidance through the summarization and performance evaluation of different design strategies of PepNzymes-SH. This review summarizes strategies for simulating and enhancing the stability of serine hydrolase active sites, oxyanion holes, and hydrophobic environmental structures. By comparing their catalytic activities, we assess the performance changes brought about by different strategies. Furthermore, the applications of PepNzymes-SH in the chemical, biomedicine, and environmental fields are also discussed.

Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from Pseudomonas aeruginosa.

The bacterium Pseudomonas aeruginosa is able to invade lung epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, it is currently unclear how OMVs from P. aeruginosa (PA-OMVs) affect lung epithelial cells and their impact on oxidative stress, autophagy, and other physiological activities of lung epithelial cells. In this study, we found that PA-OMVs activated oxidative stress and autophagy in cells. We demonstrated that the NLRP3 (NLR family, pyrin domain containing 3) inhibitor MCC950 can enhance autophagy induced by PA-OMVs. The main function of NLRP3 is related to the body's immune response and inflammation regulation. MCC950 is the most common inhibitor of NLRP3. Additionally, we showed that PA-OMVs not only enhanced the expression of AMP-activated protein kinase, a key regulator of cellular energy homeostasis, and reactive oxygen species, which play a crucial role in cellular signaling and oxidative stress, but also significantly enhanced the expression of NLRP3. Inhibiting the expression of NLRP3 further enhanced the process of PA-OMVs induced autophagy. These results demonstrate that PA-OMVs activate both autophagy and the NLRP3 inflammasome, with NLRP3 suppressing autophagy to a certain extent, hoping to provide broad ideas for the future applications of PA-OMVs.IMPORTANCEThe discovery that lung epithelial cells exposed to outer membrane vesicles from Pseudomonas aeruginosa (PA-OMVs) activate cellular autophagy and induce protective immunity is significant. Specifically, the addition of an NLRP3 inhibitor, MCC950, has been found to decrease NLRP3 targets while simultaneously enhancing the autophagy activity induced by PA-OMVs. This finding unveils a novel theoretical framework for the development of PA-OMVs vaccines, highlighting new targets for enhancing the body's anti-infective responses. By elucidating the mechanisms through which PA-OMVs trigger autophagy and bolster immune defenses, this research opens avenues for innovative vaccine design strategies aimed at combatting infections effectively.

High-Performance Oxide Crystal BaTeW2O9 X-ray Detector with High Stability, Low Detection Limit, and Ultralow Dark Current Drift.

X-ray detection materials and devices have received widespread attention due to their irreplaceable role in the medical, industrial, and military fields. In this paper, BaTeW2O9 (BTW) crystal containing lone pairs of electrons with large atomic numbers and high density is reported as a new type of oxide crystal X-ray detection material. The anisotropic X-ray detection performance of the BTW single crystal (SC) is systematically studied. At 120 keV hard X-ray photon energy, the BTW SC X-ray detectors along the crystallographic a-, b-, and c-axes directions achieved high sensitivities of 371, 404, and 368 μC Gyair-1 cm-2 respectively. More importantly, no dark current drift phenomenon was observed in the BTW SC X-ray detectors. The dark current drifts along the crystallographic a-, b-, and c-axes directions are as low as 7.81 × 10-9, 8.61 × 10-9, and 7.71 × 10-9 nA cm-1 s-1 V-1, respectively. In addition, the BTW SC X-ray detector has an ultralow detection limit of 21.9 nGyair s-1. Our research provides a new X-ray detection material with potential application value and a new material design strategy for the field of radiation detection.

Stacked Scintillators Based Multispectral X-Ray Imaging Featuring Quantum-Cutting Perovskite Scintillators With 570 nm Absorption-Emission Shift.

Traditional energy-integration X-ray imaging systems rely on total X-ray intensity for image contrast, ignoring energy-specific information. Recently developed multilayer stacked scintillators have enabled multispectral, large-area flat-panel X-ray imaging (FPXI), enhancing material discrimination capabilities. However, increased layering can lead tomutual excitation, which may affect the accurate discrimination of X-ray energy. This issue is tackled by proposing a novel design strategy utilizing rare earth ions doped quantum-cutting scintillators as the top layer. These scintillators create new luminescence centers via energy transfer, resulting in a significantly larger absorption-emission shift, as well as the potential to double the photoluminescence quantum yield (PLQY) and enhance light output. To verify this concept, a three-layer stacked scintillator detector is developed using ytterbium ions (Yb3+)-doped CsPbCl3 perovskite nanocrystals (PeNCs) as the top layer, which offers a high PLQY of over 100% and a significant absorption-emission shift of 570nm. This configuration, CsAgCl2 and Cs3Cu2I5 as the middle and bottom layers, respectively, ensures non-overlapping optical absorption and radioluminescence (RL) emission spectra. By calculating the optimal thickness for each layer to absorb specific X-ray energies, the detector demonstrates distinct absorption differences across various energy bands, enhancing the identification of materials with similar densities.

Design Strategies Applied to Classroom's Daylight Design Optimization of Classrooms Design

Design Strategies Applied to Classroom's Daylight Design Optimization of Classrooms Design

Transforming Adsorbate Surface Dynamics in Aqueous Electrocatalysis: Pathways to Unconstrained Performance.

Developing highly efficient catalysts to accelerate sluggish electrode reactions is critical for the deployment of sustainable aqueous electrochemical technologies, yet remains a great challenge. Rationally integrating functional components to tailor surface adsorption behaviors and adsorbate dynamics would divert reaction pathways and alleviate energy barriers, eliminating conventional thermodynamic constraints and ultimately optimizing energy flow within electrochemical systems. This approach has, therefore, garnered significant interest, presenting substantial potential for developing highly efficient catalysts that simultaneously enhance activity, selectivity, and stability. The immense promise and rapid evolution of this design strategy, however, do not overshadow the substantial challenges and ambiguities that persist, impeding the realization of significant breakthroughs in electrocatalyst development. This review explores the latest insights into the principles guiding the design of catalytic surfaces that enable favorable adsorbate dynamics within the contexts of hydrogen and oxygen electrochemistry. Innovative approaches for tailoring adsorbate-surface interactions are discussed, delving into underlying principles that govern these dynamics. Additionally, perspectives on the prevailing challenges are presented and future research directions are proposed. By evaluating the core principles and identifying critical research gaps, this review seeks to inspire rational electrocatalyst design, the discovery of novel reaction mechanisms and concepts, and ultimately, advance the large-scale implementation of electroconversion technologies.

Enhancing Li Deposition Behavior through Valence Gradient-Assisted Iron Layer.

Uncontrolled lithium (Li) dendrite formation presents major safety risks and challenges in the Li host design. A novel approach is introduced, using a valence gradient in iron nanoparticles (Fe0, Fe2+, Fe3+) to stabilize the anodes. An Fe0 component, with fast Li diffusion, ensures a steady supply of Li to Fe2+ and Fe3+ components, which have slower Li diffusion. This coordinated interplay between fast and slow diffusion uniformizes Li deposition near the substrate, effectively reducing the rate of dendrite growth. The as-prepared framework demonstrates uniform Li plating with a minimal hysteresis voltage after extensive cycling for 1200 h in symmetric cells. Integrated into a full cell with LiFePO4, it demonstrates outstanding cycling stability for almost 950 cycles with a capacity of 92.2 mA h g-1 at 1C with an ultralow N/P ratio of 1.19. This valence gradient design strategy broadens the design potential for transition-metal compounds in regulating Li deposition by mitigating interfacial Li+ behavior.

Brain-Computer Interface and Electrochemical Sensor Based on Boron-Nitrogen Co-Doped Graphene-Diamond Microelectrode for EEG and Dopamine Detection.

The simultaneous detection of electroencephalography (EEG) signals and neurotransmitter levels plays an important role as biomarkers for the assessment and monitoring of emotions and cognition. This paper describes the development of boron and nitrogen codoped graphene-diamond (BNGrD) microelectrodes with a diameter of only 200 μm for sensing EEG signals and dopamine (DA) levels, which have been developed for the first time. The optimized BNGrD microelectrode responded sensitively to both EEG and DA signals, with a signal-to-noise ratio of 9 dB for spontaneous EEG signals and a limit of detection as low as 124 nM for DA. Furthermore, the BNGrD microelectrodes demonstrate excellent repeatability, reproducibility, and stability for the detection of EEG and dopamine. These results indicate that the BNGrD microelectrode creates suitable conditions for establishing a correlation between the EEG signals and neurotransmitters. A flexible printed circuit board with BNGrD microelectrodes for an eight-channel EEG headband, portable EEG collector, and light stimulation glasses are designed. The self-designed EEG collector adopts a split design strategy of digital and analog signal modules and uses miniaturized impedance-matched BNGrD microelectrodes, which effectively reduce the noise of the electrophysiological signals. The BNGrD microelectrode-based portable EEG/electrochemical analysis system detects EEG signals and DA levels in a noninvasive and minimally invasive manner and has application prospects in remote online diagnosis and treatment of patients with emotional and cognition-related diseases.

Thermal insulation of military boots using a thermal foot manikin in cold environments

The purpose of this study was to investigate the thermal insulation of military boots using a thermal foot manikin, and to examine environmental and technical factors to determine their thermal insulation. Three Korean and four US military boots were chosen along with four occupational boots. All measurements were conducted at air temperatures of 21, 0, and − 5 °C with an airflow of < 0.15 m s−1. The following two calculations of thermal insulation were compared: (1) a method using values obtained from all nine zones of the foot manikin [entire-zone method], and (2) a method using values from only zones covered by the boot [partial-zone method]. The results showed that the total insulation (IT) of the 11 protective boots ranged from 0.9 to 1.2 clo per boot and no differences in thermal insulation across the three air temperatures were found. Thermal insulation had a significant and strong relationship with the thickness of the boot layer (r = 0.905, P < 0.001), whereas there was no relationship between the thermal insulation and the boot mass. The thermal insulation of military boots was 81% explained by the thickness of the boot layer alone, and 94% by both the thickness of the boot layer and boot mass (P < 0.001). Thermal insulation based on the partial-zone method was 26% greater than the values using the entire zone method. We proposed design strategies for military boots according to zonal power consumption.

The Design of Intrinsically Conductive Metal‐Organic Frameworks for Thermoelectric Materials

Thermoelectric (TE) materials offer exciting promise in the development of sustainable, green energy alternatives. Ideal TE materials promote high electrical conductivity, whilst effectively scattering phonons for reduced thermal conductivity, thus giving the phonon‐glass electron‐crystal concept. Metal‐organic frameworks (MOFs) have emerged as a versatile class of materials that could meet these criteria. The high crystallinity of MOFs can offer effective pathways for charge transport whilst their intrinsic high porosity yields ultralow thermal conductivity. The high structural diversity of MOFs, owing to the versatile coordination of metal cation/cluster and linker offers the potential to systematically tune their properties for TE performance. This review examines the advancement in the design strategies that have thus far been implemented toward intrinsically conductive MOFs and how these should be tailored for application toward TE materials. By addressing the challenges and leveraging the unique properties of MOFs, future research can pave the way for innovative and efficient TE MOF materials.

Performance optimization of high-rise residential buildings in cold regions considering energy consumption

With the acceleration of urbanization, high-rise residential buildings has become a significant aspect of urban living. However, while high-rise residential buildings provide much housing, they also bring significant energy consumption. To raise the energy utilization efficiency of high-rise residential buildings, reduce energy consumption, and achieve sustainable development, this study focuses on high-rise residential buildings in cold regions. Through methods such as parametric modeling, joint simulation of building performance, multi-objective optimization algorithms, and improved grey wolf optimization algorithms, multi-objective optimization experiments are conducted to achieve optimal energy-saving effects. The outcomes denote that the average energy consumption of buildings remains at around 20.5 kW h/m2, and the maximum value of the last generation thermal comfort solution set is maintained at 62%, while the minimum value is maintained at 58%. The improved grey wolf optimization algorithm reduces training time, has better predictive ability, and can more accurately characterize changes in energy consumption of high-rise buildings. This study provides practical design methods and strategy references for high-rise residential buildings in the design phase by analyzing data, mining patterns, and summarizing design strategies.

Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy.

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) in situ, thereby inducing oxidative stress and promoting cancer cell death. However, within the complex tumor microenvironment (TME), the rational design of nanozymes and factors like activity, reaction substrates, and the TME itself significantly influence the efficiency of ROS generation. To address these limitations, recent research has focused on exploring the factors that affect activity and developing nanozyme-based cascade catalytic systems, which can trigger two or more cascade catalytic processes within tumors, thereby producing more therapeutic substances and achieving efficient and stable cancer therapy with minimal side effects. This area has shown remarkable progress. This Perspective provides a comprehensive overview of nanozymes, covering their classification and fundamentals. The regulation of nanozyme activity and efficient strategies of rational design are discussed in detail. Furthermore, representative paradigms for the successful construction of cascade catalytic systems for cancer treatment are summarized with a focus on revealing the underlying catalytic mechanisms. Finally, we address the current challenges and future prospects for the development of nanozyme-based cascade catalytic systems in biomedical applications.

Rational Design Two‐ or Four‐Electron Reaction Pathway Covalent Organic Frameworks for Efficient and Selective Electrocatalytic Hydrogen Peroxide Production

Covalent organic frameworks (COFs) are often employed in oxygen reduction reactions (ORR) for hydrogen peroxide production due to their tunable structures and compositions. However, COF electrocatalysts require precise structural engineering, such as heteroatoms or metal site doping, to modulate the reaction pathway during the ORR process. In this work, we designed a tetraphenyl‐p‐phenylenediamine based COF electrocatalyst, namely TPDA‐BDA, which exhibited excellent two‐electron (2e) ORR performance with high H2O2 selectivity of 89.7% and faraday efficiency (FE) of 86.7%, higher than the reported COFs to date for H2O2 electrosynthesis. The theoretical and experimental results showed that the rate‐determining step energy barrier for reduction of O2 to OOH* intermediates was significantly reduced by replacing of bipyridine with biphenyl blocks, changing from 4e to 2e ORR reaction pathway. Also, the donor‐acceptor characteristic and narrower optical band gap of TPDA‐BDA COF enhanced the electronic conductivity and reduction ability, thus elevating the catalytic activity. As a result, the H2O2 selectivity was maintained above 85% even after 50 h stability test. This work reveals the structure‐property relationship of COF electrocatalysts and provides a new strategy for rational design of high performance 2e ORR COF electrocatalysts for efficient and selective hydrogen peroxide production.

Rational Design Two- or Four-Electron Reaction Pathway Covalent Organic Frameworks for Efficient and Selective Electrocatalytic Hydrogen Peroxide Production.

Covalent organic frameworks (COFs) are often employed in oxygen reduction reactions (ORR) for hydrogen peroxide production due to their tunable structures and compositions. However, COF electrocatalysts require precise structural engineering, such as heteroatoms or metal site doping, to modulate the reaction pathway during the ORR process. In this work, we designed a tetraphenyl-p-phenylenediamine based COF electrocatalyst, namely TPDA-BDA, which exhibited excellent two-electron (2e) ORR performance with high H2O2 selectivity of 89.7% and faraday efficiency (FE) of 86.7%, higher than the reported COFs to date for H2O2 electrosynthesis. The theoretical and experimental results showed that the rate-determining step energy barrier for reduction of O2 to OOH* intermediates was significantly reduced by replacing of bipyridine with biphenyl blocks, changing from 4e to 2e ORR reaction pathway. Also, the donor-acceptor characteristic and narrower optical band gap of TPDA-BDA COF enhanced the electronic conductivity and reduction ability, thus elevating the catalytic activity. As a result, the H2O2 selectivity was maintained above 85% even after 50 h stability test. This work reveals the structure-property relationship of COF electrocatalysts and provides a new strategy for rational design of high performance 2e ORR COF electrocatalysts for efficient and selective hydrogen peroxide production.

“Everyone wears mitts”: Reflections on the use of metaphors in knowledge co-production in Nunavut, Canada

Co-production has emerged as foundational to meaningful community-based Arctic research, placing Inuit leadership as central to knowledge creation. When founded upon strong relationships, co-production incorporates Indigenisation into research design, theoretical basis, data collection and analytical strategies. Here, we discuss and reflect on our experiences using metaphor as a bridge to meaningful engagement and knowledge co-production between southern-based researchers and an Inuit youth team. As a guiding metaphor for this project, we used the process of ‘making mitts’ (pualungnit in Inuktitut; pualuk meaning ‘mitten’), from identifying a need, to the action of crafting and using them. Our work indicates that metaphors can be very useful in facilitating knowledge co-production in a cross-cultural context by being adaptive to youth needs and overlaying the familiar and the unfamiliar. The introduction of the ‘mitt’ metaphor led to a completely novel creation process where youth contributors felt empowered, even compelled, to critique the work undertaken, freely and honestly without fear of repercussion or embarrassment. In discussing the process of sewing mitts, they stepped into the role of experts. As a result, the metaphor facilitated the creation of accessible and safe spaces within which to work and build relationships.