The complexities of pharmaceutical supply chains in emerging markets present significant challenges that directly impact healthcare outcomes, particularly in underserved regions. This research focuses on the optimization of supply chain systems for the healthcare sector, with an emphasis on enhancing pharmaceutical delivery. By leveraging data analytics and innovative procurement strategies, the study seeks to improve efficiency, reduce operational costs, and ensure the timely distribution of essential medications. Drawing on practical experiences at eMedic Technologies Africa, the research highlights the need for advanced models that integrate real-time data to optimize inventory management, forecast demand, and address bottlenecks in last-mile delivery. The study proposes a multi-faceted approach to addressing common challenges in emerging market supply chains, including unreliable infrastructure, fluctuating demand, and limited access to technology. By utilizing predictive analytics, the proposed models aim to improve accuracy in demand planning, reducing stockouts and overstock situations. Additionally, innovative procurement strategies, such as centralized procurement and strategic partnerships with local suppliers, are explored as key methods for enhancing cost-effectiveness and streamlining supply chain operations. A critical component of the research is the focus on last-mile delivery, which remains a significant hurdle in rural and underserved areas. The study advocates for the use of digital platforms and mobile technologies to enhance delivery tracking and coordination, ensuring that essential medications reach their destination efficiently. Furthermore, it emphasizes the importance of fostering collaboration between governments, non-governmental organizations, and private sector stakeholders to build resilient supply chain systems capable of adapting to local conditions. By providing actionable insights and scalable models for supply chain optimization, this research aims to contribute to improved healthcare delivery in emerging markets. The proposed strategies not only reduce costs and improve efficiency but also ensure a reliable and consistent supply of medications, ultimately leading to better health outcomes in regions most in need. Keywords: Supply Chain Optimization, Data-Driven Procurement, Last-Mile Delivery, Healthcare Efficiency, Emerging Markets