The aim of this study was to evaluate the stress distribution and displacement values of six different miniplate systems in large mandibular advancement after sagittal split ramus osteotomy (SSRO) with finite element analysis (FEA). A three-dimensional model of a mandible was created and a 10 mm advancement SSRO was simulated. The model was fixed using a four-hole miniplate, a six-hole miniplate, a newly designed six-hole miniplate and their curved versions. Maximum principal stress values for bone, von Mises stress values for osteosynthesis materials, and the amount of displacement between segments were measured. The highest von Mises value was observed in the curved version of the newly designed six-hole miniplate; the lowest value was detected in the four-hole curved miniplate. The lowest value of maximum principal stress in the bone was found in the curved version of the novel design six-hole miniplate. The least displacements between segments were also recorded in the new design of straight miniplate; therefore, for large mandibular advancement surgery, this novel six-hole miniplate may be a promising option with positive biomechanical characteristics.