The basic peculiarities of the hydrological regime of one of the largest mouth areas of the world, i.e., the common mouth of the rivers of Ganges and Brahmaputra, are discussed. The main features of natural conditions (including climatic) of the mouth of these rivers and the delta drainage system are characterized. The hydrological regime of the Ganges and Brahmaputra rivers, the largest rivers of South Asia, is studied in greater detail; the quantitative assessments of the water and sediment runoff of these rivers are specified. Provision is made for revealing the basic peculiarities of river flow distribution among numerous delta branches, annual floods during southwest monsoons, tidal phenomena in the maritime zone of the delta, and disastrous storm surges and inundations in the period of tropical cyclones. Flood control measures taken in Bangladesh to protect the population and lands are described.