Stone Breaker Research Articles

Comprehensive analysis of nutritional activity in Garcinia kola stem bark (Clusiaceae), Stone Breaker (Phyllanthus niruri) leaves and their blends: Implications for therapeutic applications

This study investigates the nutritional and mineral composition of Garcinia kola Stem Bark (Clusiaceae) and Stone Breaker (Phyllanthus niruri) leaves, processed through fermentation, blanching, and drying, to evaluate their potential health benefits. The samples were divided into three groups: Garcinia kola Stem Bark, Stone Breaker, and a 50 %:50 % mixture of both. The proximate analysis revealed significant variations. Moisture content ranged from 6.03 % to 7.38 %, with blanched Stone Breaker having the lowest and blanched Garcinia kola the highest, indicating differences in storage stability. Fermented samples showed higher ash content (up to 8.66 %), suggesting increased mineral availability due to microbial activity. Protein content was highest in fermented Stone Breaker (19.73 %), highlighting the benefits of fermentation in enhancing protein levels. Mineral analysis showed that blanched Stone Breaker had the highest potassium content (1872.8 mg/100 g), beneficial for cardiovascular health, while fermented samples had notable levels of calcium (402.2 mg/100 g) and magnesium (426.8 mg/100 g), supporting bone health and energy metabolism. Fermented Stone Breaker also emerged as the best overall sample due to its high protein content, higher ash content, and balanced moisture and fat levels, making it nutritionally rich and stable for storage. These findings emphasize the impact of processing methods on the nutritional and mineral profiles of herbal blends. Fermented Stone Breaker, in particular, offers a promising balance of essential nutrients for dietary enhancement and therapeutic health promotion.

Behind the Hammer's Swing: Work Fatigue Among Traditional Stone Breakers in the Coastal Region of the Selayar Islands, Indonesia

Behind the Hammer's Swing: Work Fatigue Among Traditional Stone Breakers in the Coastal Region of the Selayar Islands, Indonesia

Stone Breaker: The Poet James Gates Percival and the Beginning of Geology in New England

Stone Breaker: The Poet James Gates Percival and the Beginning of Geology in New England

Antiplasmodial and interferon-gamma-modulating activities of the aqueous extract of stone breaker (Phyllanthus niruri Linn.) in malaria infection.

Plasmodium falciparum parasites are the primary cause of malaria across Africa. The problem of drug resistance to malaria is ever growing and novel therapeutic strategies need to be developed, particularly those targeting the parasite and also the host or host-pathogen interaction. Previous studies have shown that the development of cerebral malaria (CM) is related to dysregulation of the immune system in a murine malaria model of experimental cerebral malaria. It involves a complex interaction of events and interferon-gamma seems to be the unifying factor. Therefore, the antiplasmodial activity targeting the parasite and immunomodulatory strategies that reduce overall host inflammation, with IFN-γ in focus, could delay CM onset and prove beneficial in malaria infection therapy. Phyllanthus niruri is used to treat fever and other symptoms of malaria in Nigeria. Its modes of action as an anti-malarial remedy have not been exhaustively investigated. This study therefore examined the aqueous extract of P. niruri (PE) for its antiplasmodial activity in vitro using the Plasmodium falciparum HB3 strain. Furthermore, in vivo murine malaria model using the Plasmodium berghei ANKA strain was used to investigate its anti-malarial effects. We showed that PE has multiple anti-malarial effects, including anti-parasitic and host immunomodulatory activities. Co-culture of P. falciparum with PE and some of its phytoconstituents drastically reduced parasite number. PE also decreased parasitemia, and increased the survival of infected mice. We also observed that the integrity of the blood-brain barrier was maintained in the PE-treated mice. The results confirmed that PE showed moderate antiplasmodial activity. In vivo murine malaria model using P. berghei ANKA for experimental cerebral malaria revealed that PE suppressed parasite growth, and modulate the production of interferon-gamma. The findings demonstrate that PE affects malaria progression, targeting parasites and host cells.

TREATMENT OF UROLITHIASIS WITH TEMPUYUNG LEAF IN LOCAL CAT

Urolithiasis is a condition of calculi formation as a result of urine supersaturation, consisting of one or several type of mineral such as calcium oxalate, and phosphate that can move down along the ureters, bladder, and urethra. Urolithiasis is one of the most common diseases in animal. as many as 50 of 385 cats experienced urolithiasis. Tempuyung (Sonchus arvensis L.) is one of the medicinal plants that was efficacious as a kidney stone breaker and urine streamer. organic compounds such as flavonoids efficacious break the kidney stone and treat inflammation of the urinary tract. This reported case occurred in a local cat, male, 4.5 years old, 3.6 kg, who came to the Teaching Veterinary Hospital, Faculty of Veterinary Medicine, Udayana University, with difficulty urinating for a few days and when the urine came out it looked mixed blood. Physical examination showed cat was dehydrated. Supportive examinations were carried out in the form of hematological examination, ultrasonography (USG), and urine sedimentation. The result of the hematological examination showed that the animal had hypochromic microcytic anemia, ultrasound result showed calculi in the urinary bladder. The animal was diagnosed with urolithiasis with a dubius-fausta prognosis. The therapy that has given was fluid therapy, injection therapy with amoxicillin (antibiotic), and herbal medicine tempuyung leaves (oral). The cat's condition improved after therapy, characterized by urination without hematuria and no pain during urination, and it is recommended that the feed pattern be changed to wet feed.

The Vicious Circle of Marginalization of the Kokoda Tribe in Sorong, Southwest Papua

Objective: to analyze the complexity of marginalization faced by the Kokoda Tribe in Sorong, Southwest Papua. Theoretical framework: The Gramsci's theory of hegemony explains that the dominance of intellectual and moral leadership by the ruling class caused the complexity of marginalization. Methods: qualitative research with a critical ethnographic approach. Data were found through field observations, in-depth interviews, and documentation. The data were processed through the stages of ethnographic discovery, making ethnographic notes, and ethnographic descriptions. Data were analyzed through four stages: domain analysis, taxonomy analysis, component analysis, and theme analysis. Results and conclusion: the complexity of marginalization of the Kokoda Tribe, including psychological marginalization: negative stereotypes such as destroyers of nature, criminals, and low work ethic. Political marginalization: political monopoly and political victimization. Economic marginalization: jobs that only come from nature, such as stone breaking and selling mangroves. Social marginalization: ostracism and limited information. Educational marginalization: very low education. The vicious circle of marginalization experienced by the Kokoda Tribe is the result of the hegemony of the dominant group's power. Research implications: Suggestions to the government, academics, and social institutions to help improve the quality of life of the Kokoda Tribe who are independent, dignified, and able to create a sustainable living environment. Originality: The causes of marginalization are not always external, but can also be internal, such as the domination of indigenous Papuan ruling groups.

Phytochemical, pharmacological potential and ethnomedicinal uses on Phyllanthus amarus: A review

Ethnomedicinal plants are especially important for human health by prevention of various human diseases. One of such ethno medicinal plant species which used, widely to Phyllanthus amarus. Phyllanthus amarus belongs to family Euphorbiaceae. Stone breaker, Gala of wind, Bhumi Amla, Jangli Amla and carry me seeds are called unique name of this plant. It is popular in aboriginal system of medicine like Siddha, Ayurveda, and Unani homeopathy and is used for its antidiabetic, antitumor, hepatoprotective, antihypertensive, and analgesic, anti - inflammatory and antimicrobial properties. This plant is used in diarrhoea, intermittent fevers, cold, jaundice, dropsy and has used as a good anti - viral activity against hepatitis-B virus. The whole plant of Phyllanthus amarus is rich store house of several types of phytochemicals such as quercetin, geraniin, phylanthin, hypothylanthin, rutin, norsecurinine etc. Phyllanthus amarus has also served for various experimental investigations that detailed its pharmacological uses and phytochemical constituents. The present review compiles ethnomedicinal uses phytochemical and pharmacological properties of Phyllanthus amarus.

Risk Factors for Carpal Tunnel Syndrome in Informal Sector Workers: Literature Review

CTS is one of the diseases that occurs in many workers so it is often referred to as work-related Carpal Tunnel Syndrome. The high number of informal workers allows for high accidents in the workplace. The purpose of this study is to discuss the risk factors for the incidence of CTS in informal sector workers. This research is a descriptive research with the literature review method. The literature search strategy uses a prism flow chart, and inclusion and exclusion criteria. The databases used include: PubMed, Taylor and francis, and Google Scholar. From the 20 articles, 19 of them used the cross-sectional type of research, and 1 article used the case-control type of research. The types of informal work obtained from the 20 articles are: motorcycle taxi drivers, farmers, batik and bead craftsmen, blacksmiths, stone breakers, meatball sellers, coconut peelers, woodcarvers, tailors, angkot drivers, small-scale convection, hairstylists, and butchers. Overall, the journal articles obtained discuss related to the risk factors for the incidence of CTS in informal sector workers. Repetitive movements, length of service, length of work, hand posture (awkward), age, gender, and body mass index were found to influence the incidence of CTS in informal sector workers. Meanwhile, grasping work and a history of diabetes mellitus were not found to be related to the incidence of CTS in informal sector workers.

Combination of Nigella sativa and Phyllanthus niruri as An Immunostimulant for The Prevention of White Spot Disease in Litopenaeus vannamei

Pacific whiteleg shrimp (Litopenaeus vannamei) is a very important commodity, which accounts for almost 70% of the total world shrimp production. However, this production is still threatened by disease attacks, one of which is caused by white spot disease (WSD). Herbs are widely used as immunostimulants as an effort to prevent diseases. Black cumin (Nigella sativa) and stone breaker (Phyllanthus niruri) have long been known as excellent immunostimulants in human. This study aimed to evaluate the potential of N. sativa and its combination with P. niruri as an immunostimulant in L. vannamei for preventing WSD. Tested shrimp (±3.0 g) were treated by N. sativa (N), P. niruri (P) and the combination of both (1N:1P, 2/3N:1/3P, 3/4N:1/4P, 1/3N:2/3, 3/5N:2/5P, 1/4N: 3/4P, 2/5N:3/5P) through feed for 28 days. They were then infected by white spot syndrome virus (WSSV) and observed for 7 days. The parameters observed included immune response and production performance. N. sativa was able to reduce the mortality of test shrimp infected with WSSV, with an RPS value of 71%. N. sativa can be combined with P. niruri in the right composition (1/2N:1/2P and 2/3N:1/3P), while the other combinations are antagonistic. The administration of the best treatments in this study, relatively did not affect the value of total hemocyte count, phenoloxidase activity, respiratory burst activity, hemolymph clotting time and production performance of tested shrimp.

Pendidikan, Pengetahuan Dan Penggunaan Alat Pelindung Diri Pekerja PT. Martadinata Indah Tambang Kabupaten Donggala

Occupational safety and health contain the value of protecting workers from accidents or occupational diseases. Personal protective equipment is important to protect workers from injuries or illnesses caused by exposure to hazards in the workplace. PT. Martadinata Indah Tambang is a company that produces stone, gravel, crushed stone, and sand, located in Alindau Village, Sindue Tobata District, Donggala Regency with 89 workers and most of them have primary school education (48%). The work fields consist of sand production, gravel production, drivers, stone breaking, welding, heavy equipment, electricity, mechanics, checkers, drivers, logistics, and security. Workers in the production department were at risk of work accidents as they interacted directly with equipment and materials and were exposed to a work environment that had the potential to pose the risk of accidents and occupational diseases. This study aimed to analyze the relationship between education and knowledge with the use of personal protective equipment (PPE). This was an observational study with a cross-sectional design. The population size is 89 workers, and 47 workers as sampled by accidental sampling. As the results, using Chi-square for the statistical test, there was a significant relationship between the level of education and the use of personal protective equipment (p-value = 0,015), and also there was a significant relationship between knowledge and the use of personal protective equipment (p-value=0,003). The company should control the risk of hazards to avoid possible occupational diseases and work accidents.

Call me pot if you like it, but do not put me in the stove / Hot’ gorshkom nazovi, tol’ko v pechku ne stav’ (Engl.: Sticks and stones break my bones, but names will never hurt me): a paradox or a regularity governing naming?

The paper addresses the issue of establishing the naming motive reflected in the Russian saying which is well-known in colloquial language, national fiction, and journalism. The existing common and scientific interpretations of the saying are critically examined. The historical and lexicological analysis of the use of the word gorshok (engl. pot) in Russian written manuscripts, folk subdialects, and lexicographic sources enables the author to reveal the reasons why the lexeme was included in the saying. Taking into account the syntactic structure of the saying and the function of the conjunction hot’ (engl. though), an attempt is made to adequately interpret the meaning and motive for this nominating.

Immunomodulatory effect of

Immunomodulators are being used to revive immune imbalance which helps in preventing and healing many diseases. Phyllanthus niruri (P. niruri) which is commonly called as stone breaker is widely distributed in tropical areas and known for its various ethnomedicinal and pharmacological effects. P. niruri is intensively being studied for its immunomodulating effects because of its wide-ranging uses in treating diseases related to immune system in indigenous medicine by scientifically studying and evaluating it in various clinical trials for the treatment of Pulmonary Tuberculosis, chronic Hepatitis- B, Varicella-Zoster and Vaginitis infection. In such diseases, effective immune system is essential for curing the disease and elimination of the pathogens. It has proved for its ability to modulate and activate the immune system through clinical studies.

A new Critically Endangered species of stone breaker (Phyllanthus, Phyllanthaceae) from Central Brazil, with notes on its leaf and stem anatomy

A new species from the state of Goiás, Brazil, Phyllanthus pterocaulis, is described and illustrated, with comments on its geographic distribution and environmental preferences, phenology, morphological relationships, and systematic position. It is morphologically allied with Phyllanthus avicularis, P. heliotropus, and P. hyssopifolioides, but differs from all of them by a set of characters related to cymules sex, presence and types of trichomes on leaves and stems, leaf consistency, numbers of sepals in flower of both sexes, integrity of stamens, capsules and seeds. Additionally, we provide images of the new species in the field, conservation status, mapped distribution, the anatomical description of its stem and leaves, and a key to differentiate it from the other similar species belonging to Phyllanthus sect. Loxopodium occurring in Brazil. The new species is one of the few in the genus that occurs in shaded environments in seasonal dry forests within the Cerrado biome.

Phytochemical screening and antimicrobial activity of shade dried and sun-dried Aerva lanata (L.) juss. ex schult.

Aerva lanata (L.) Juss. ex Schult. is an important medicinal plant widely used in the treatment of several human ailments in the southern part of India including as a source of Pashana Bheda (Stone Breaker). The plant materials were extracted in different solvent extracts and analyzed to know the composition of minerals, secondary metabolites and the efficacy of solvent extracts against pathogenic bacteria and Candida species. Ethyl acetate extract of sun-dried plant inhibited the growth of S. typhie and K. pneumoniae. The anticandidal activity displayed in ethyl acetate and methanol extracts was very effective against C. glabrata, C. albicans and C. haemulonii respectively. A maximum of 11.834 ppm calcium content was recorded, followed by potassium (6.87 ppm) and magnesium (6.5 ppm). Similarly, amongst the secondary metabolites, saponins (1.987 mg/g) content was maximum, followed by flavonoids (1.85 mg/g) and sterol (0.85 mg/g) in sundried plant material. In shade dried plant material, phenol content was more (1.14 mg/g). No significant difference was observed in the occurrence of secondary metabolites, minerals, and antimicrobial activity between sundried and shade dried plant materials.

Chemical Composition and Antibacterial Activity of Extracts of Cymbopogon Citratus (Lemon Grass) and Phyllantus Amarus (Stone Breaker) Leaves

This study described the chemical composition, antioxidant and antibacterial activities of the ethanol and aqueous extracts of fresh and dried leaves of Phyllantus amarus (PA) (Stone breaker), Cymbopogon citratus (CC) (Lemon grass) and combination of stone breaker and lemon grass (PA/CC and DL/DP) using standard methods. The proximate and mineral results showed that both fresh and dried samples of Phyllantus amarus and Cymbopogon citratus were rich in crude fibre (18.53%, 14.65%), ash (16.27%, 2.29%), potassium (95.56 mg/100g, 54.04 mg/100g), calcium (58.57 mg/100g, 7.05 mg/100g), and sodium (15.23 mg/100g, 9.84 mg/100g) respectively. The ability of the extracts to scavenge 2, 2 diphenyl -2- picryl-hydrazyl (DPPH) radical showed that the fresh PA had the highest scavenging activity of 91.12 mg/g, followed (PA/CC) 90.93 mg/g and dried PA (85.61mg/g). The phytochemical composition of the extracts also revealed that they contain high content of cardiac glycoside (11.62 mg/g - 64.81 mg/g), terpenoid (14.56 mg/g - 69.66 mg/g), phenol (14.73 mg/g - 53.93 mg/g), saponin (22.61 mg/g - 30.47mg/g). Dried lemon and dried Phyllantus amarus (DL/DP) was found to be rich in Vitamin A (22.22 mg/g), while the lowest value of Vitamin E (0.36 mg/g) was obtained from fresh lemon grass (0.36mg/g). Antibacterial assay carried out on the two leaves extracts showed that they produced mild antibacterial activity against some foodborne pathogen (Bacillus cereus, Shigella dysenteriae, Escherichia coli, Salmonella spp, Staphylococcus aureus, Pseudomonas spp). with zones of inhibition of 4.3 mm -9.1mm. Further studies should be carried out to investigate the employment of the leaves in production of functional food

Time Allocation and Economic Contribution of Women in Fulfilling the Basic Needs of Poor Households

The primary purpose of this study is to explore the time allocation and economic contribution of women in fulfilling their families’ basic needs. This research used a qualitative approach and applied observations and interviews as the data collection technique. The research sample consisted of 25 people, including 23 stone-breaking women, who have a family, and 2 village heads, whose village areas contain stone-mining enterprises. The obtained data was analysed qualitatively, implying that the processes of data collection, data reduction, data display, and data verification were carried out simultaneously. The results of this study show that the respondents allocate more time to household chores than to stone-breaking work. However, through the activities as a stone breaker, homemakers do make a significant economic contribution to the family’s income. Indeed, the sole reliance on the husband’s income as the head of the family cannot be sufficient for fulfilling the basic needs. The husband’s income only serves to maintain the survival of the family.

David Blackstock: Distortion of shock waves and breaking of kidney stones

This talk will discuss how the seminal work that David Blackstock carried out in nonlinear acoustics for underwater and atmospheric applications contributed to the understanding of the medical use of shock waves for breaking of kidney stones. David’s expertise lead to him acting as an external advisor for two decades to a NIH funded programme in shock wave lithotripsy; that contribution will be covered elsewhere in the session. I will present the weak shock theory that describes how nonlinear pulses distort when undergoing geometrical spreading. The theory will then be applied to the first clinically approved lithotripter, that employed a spark to generate a shock wave and an ellipsoidal reflector to focus that into the body. Inside the reflector the shock wave undergoes spherical spreading, reflection and then spherical convergence. It will be shown that nonlinear distortion inside the reflector results in variations in phase and amplitude across the mouth of the reflector which then impact the focusing of the shock wave onto a kidney stone. I will reflect on David’s role as a Ph.D. supervisor and his mentorship of acousticians young and old.

PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT ACTIVITIES OF THE STEM AND LEAVES EXTRACT OF Phyllanthus niruri OBTAINED FROM ADAMAWA STATE, NIGERIA.

Phyllanthus are genus of a flowering plants used in herbal medicine. Commonly used in Ayurvedic healing, Phyllanthus niruri (P. niruri) known as “STONE BREAKER” are one of the herbal medicinal plants that has a broad range of properties, which are antiviral activities against hepatitis B, antimicrobial, hepatoprotective, anticancer, and hypocalcemic agent. This research were conducted to screen the phytochemical composition, evaluate the antioxidant assay using trolox and gallic acid is control and to determine the antioxidant content of P. niruri extract using rutin and quercetin as standard, which are flavonoids possessing medicinal properties. The qualitative phytochemical screening assay on P. niruri extract showed that the extract had a high content of saponins (+++), a moderate content of phenols, flavonoids, and tannins (++). It also had a low content of steroids, but triterpenoids, terpenoids, and alkaloids were not detected in the screening (-). Rutin and quercetin contents of the crude extracts were determined using high performance liquid chromatography (HPLC) and the antioxidant activity assay were measured using UV-Spectroscopy by 1, 1-diphenyl-2-picryl-hydroxyl (DPPH) method. The result show that the concentrations of quercetin and rutin in the sample analyzed were 185.96±0.5 and 91.68±0.21 µg/g respectively while the DPPH IC50 values of the crude extract were 62.05 µg/ML. The significant amounts of these antioxidants confirm the nutritional and medicinal value of the plants sample.

MP22-07 IN VIVO ASSESSMENT OF STONE FRAGILITY USING COMPUTED TOMOGRAPHY

You have accessJournal of UrologyImaging/Radiology: Uroradiology II (MP22)1 Sep 2021MP22-07 IN VIVO ASSESSMENT OF STONE FRAGILITY USING COMPUTED TOMOGRAPHY Dane Klett, Aaron Potretzke, Andrea Ferrero, Tristan Juvet, Marcelino Rivera, John Knoedler, Jayse Weaver, John Lieske, Felicity Enders, and Cynthia McCollough Dane KlettDane Klett More articles by this author , Aaron PotretzkeAaron Potretzke More articles by this author , Andrea FerreroAndrea Ferrero More articles by this author , Tristan JuvetTristan Juvet More articles by this author , Marcelino RiveraMarcelino Rivera More articles by this author , John KnoedlerJohn Knoedler More articles by this author , Jayse WeaverJayse Weaver More articles by this author , John LieskeJohn Lieske More articles by this author , Felicity EndersFelicity Enders More articles by this author , and Cynthia McColloughCynthia McCollough More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002013.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Computed tomography (CT) is recommended for non-invasively imaging symptomatic urinary stones as it provides accurate submillimeter details of stone size and location within the urinary system. Previous ex vivo studies demonstrated routine dual-energy CT (DECT) stone protocols provide an accurate estimate of stone fragility by quantifying morphological features. The objective of this study was to validate the accuracy of a stone fragility model based on preoperative DECT to predict comminution time in patients undergoing percutaneous nephrolithotripsy (PCNL). METHODS: Patients received a DECT followed by PCNL using the ShockPulse SE ultrasonic lithotripter (Olympus). A quantitative model consisting of 7 DECT metrics, including stone volume, internal and surface morphology and stone composition, was developed using stones ex vivo stones and then applied in vivo to stone procedures. During the procedure, the time the ultrasonic lithotripter was actively engaged in stone breaking was measured. The observed and predicted comminution times for each stone were individually ranked from most to least fragile. Stone fragility classifications based on comminution time were then created: soft stones in the first quartile, hard stones in the last quartile and average stones in between. Postprocedure, the performing urologist subjectively assessed stone fragility, and was blinded to measured and estimated comminution times. RESULTS: A total of 11 stones from 10 patients were studied. With stones ranked by volume, the average ranking difference (predicted vs actual comminution time) was 1.8 with 4/11 having a ranking difference greater than 2. Using the stone fragility model, the average ranking difference was 0.7, with only one stone having a ranking difference greater than 2. The 3-class classification showed only 2 stones erroneously labeled using the predictive stone fragility model. The urologist's impression of stone fragility correlated well with comminution time-based classification. CONCLUSIONS: A predictive stone fragility model based on morphological and mineral characteristics of renal stones, as quantified on DECT, may accurately predict in vivo comminution time. Source of Funding: Grants DK100227 & EB028591 from the National Institute of Health © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e393-e393 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dane Klett More articles by this author Aaron Potretzke More articles by this author Andrea Ferrero More articles by this author Tristan Juvet More articles by this author Marcelino Rivera More articles by this author John Knoedler More articles by this author Jayse Weaver More articles by this author John Lieske More articles by this author Felicity Enders More articles by this author Cynthia McCollough More articles by this author Expand All Advertisement Loading ...

Atomistic Assessment of Cystine Kidney Stone Behavior in a Mechanical Breakdown Process by Nanobiorobots through Classical Molecular Dynamics Simulations.

Because cystine kidney stones are a more serious challenge for health-related quality of life than other types of kidney stones, the search for a new treatment for cystinuria is considered the main goal of this study. To achieve the defined goal, classical molecular dynamics simulations and quantum mechanics calculations were implemented in this study. Three nanodrills with different stiffnesses (i.e., silicon, silica, and silicon carbide) were selected to find the efficient nanodrill to break the kidney stones into smaller pieces. The related nanodrills under various forces from 20 to 100 eV/Å inclusive were exerted on the cystine kidney stones to determine the effect of the force magnitude on the rate of destruction. The exerted forces were modeled via a hypothetical spring force. To bring this investigation closer to reality, the urinary tract and the bulk of cystine kidney stones were modeled by simulation of the real blockage of the kidney stones. The obtained results from quantum mechanics calculations reveal the strong interaction (chemisorption) between the cystine stone components. Moreover, the molecular dynamics simulations show that an increase in force does not necessarily lead to more destruction of cystine kidney stones. The maximum rate of cystine kidney stone destruction occurs under forces of 80, 70, and 60 eV/Å for SiO2, Si, and SiC nanodrills, which is about 19, 13, and 11%, respectively. In addition, the SiO2 nanodrill has more crossing time and z-direction deformation than other nanodrills due to the attractive interaction between SiO2 and stones, it shows less deformation during the process of kidney stone breaking because of repulsive interactions between the nanodrill and the kidney stone.