ABSTRACTA fault isolation, estimation and fault‐tolerant control algorithm is proposed for non‐Gaussian stochastic distribution control systems with disturbance and multiple sensor faults. Sensor faults are represented as actuator faults virtually, and an observer is devised to detect the sensor fault occurrence time. Then two subsystems are separated by the expanded system through introducing the coordinate transformation matrices. One subsystem contains only sensor faults and does not contain disturbance and the other contains sensor faults and disturbance, which provides convenience for fault isolation. The faults are estimated respectively by the multiple fault isolation observers with the same number of sensors. A fault‐tolerant control scheme is proposed after getting the fault information to compensated sensor faults and track the desired probability density function. Finally, a MATLAB simulation example is used to verify the feasibility of the algorithm.